mRNA vaccine in cancer therapy: Current advance and future outlook

Li, Youhuai; Wang, Mina; Peng, Xueqiang; Yang, Yingying; Chen, Qishuang; Liu, Jiaxing; She, Qing; Tan, Jichao; Lou, Chuyuan; Liao, Zehuan; Li, Xuexin

doi:10.1002/ctm2.1384

Cited by 20 publications

(5 citation statements)

References 231 publications

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“…Furthermore, mRNA vaccines are degraded easily (which reduces risk of toxicity), providing humoral and cellular immunity, which are essential for antitumor responses. Additionally, mRNA vaccine production is fast and inexpensive [313][314][315][316]. There are four major types of transcribed mRNA: conventional mRNA, self-amplifying mRNA (samRNA), trans-amplifying RNA (tamRNA), and circular mRNA (circmRNA) [317][318][319][320].…”

Section: Mrna-based Vaccinesmentioning

confidence: 99%

Recent Findings on Therapeutic Cancer Vaccines: An Updated Review

Sheikhlary,

Lopez,

Moghimi

et al. 2024

Biomolecules

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Cancer remains one of the global leading causes of death and various vaccines have been developed over the years against it, including cell-based, nucleic acid-based, and viral-based cancer vaccines. Although many vaccines have been effective in in vivo and clinical studies and some have been FDA-approved, there are major limitations to overcome: (1) developing one universal vaccine for a specific cancer is difficult, as tumors with different antigens are different for different individuals, (2) the tumor antigens may be similar to the body’s own antigens, and (3) there is the possibility of cancer recurrence. Therefore, developing personalized cancer vaccines with the ability to distinguish between the tumor and the body’s antigens is indispensable. This paper provides a comprehensive review of different types of cancer vaccines and highlights important factors necessary for developing efficient cancer vaccines. Moreover, the application of other technologies in cancer therapy is discussed. Finally, several insights and conclusions are presented, such as the possibility of using cold plasma and cancer stem cells in developing future cancer vaccines, to tackle the major limitations in the cancer vaccine developmental process.

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Section: Mrna-based Vaccinesmentioning

confidence: 99%

Recent Findings on Therapeutic Cancer Vaccines: An Updated Review

Sheikhlary,

Lopez,

Moghimi

et al. 2024

Biomolecules

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show abstract

“…The mechanisms of tumor vaccine include enhancing immunity, overcoming tumor immunosuppression, and inhibiting tumor angiogenesis. At present, different kinds of vaccines have been developed such as DNA vaccine, mRNA vaccine, adenovirus vaccine, whole cell vaccine to cope with different degrees of anti-tumor immune response [32][33][34][35]. With the continuous development of nanotechnology, making tumor vaccines with nanocarriers has become a hot topic.…”

Section: Tumor Vaccinesmentioning

confidence: 99%

The Advanced Research Progress of Tumor Immunotherapy

2024

CCR

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“…Prophylactic vaccines, which are similar to traditional vaccines, primarily target pathogenic microorganisms directly related to cancer, such as Human papillomavirus (HPV) and hepatitis B virus (HBV). In addition, there are therapeutic vaccines for patients who already have cancer and these promote the establishment of a lasting immune memory and a long-term anti-tumor response by inducing immune responses primarily against 'autoantigens' present in tumors ( 19 ).…”

Section: Treatment Of Cancermentioning

confidence: 99%

mRNA vaccine development and applications: A special focus on tumors (Review)

Chen,

Yang,

Wang

et al. 2024

Int J Oncol

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Cancer is characterized by unlimited proliferation and metastasis, and traditional therapeutic strategies usually result in the acquisition of drug resistance, thus highlighting the need for more personalized treatment. mRNA vaccines transfer the gene sequences of exogenous target antigens into human cells through transcription and translation to stimulate the body to produce specific immune responses against the encoded proteins, so as to enable the body to obtain immune protection against said antigens; this approach may be adopted for personalized cancer therapy. Since the recent coronavirus pandemic, the development of mRNA vaccines has seen substantial progress and widespread adoption. In the present review, the development of mRNA vaccines, their mechanisms of action, factors influencing their function and the current clinical applications of the vaccine are discussed. A focus is placed on the application of mRNA vaccines in cancer, with the aim of highlighting unique advances and the remaining challenges of this novel and promising therapeutic approach.

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mRNA vaccine in cancer therapy: Current advance and future outlook

Cited by 20 publications

References 231 publications

Recent Findings on Therapeutic Cancer Vaccines: An Updated Review

Recent Findings on Therapeutic Cancer Vaccines: An Updated Review

The Advanced Research Progress of Tumor Immunotherapy

mRNA vaccine development and applications: A special focus on tumors (Review)

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