mRNA Metabolism in Health and Disease

Romão, Luı́sa

doi:10.3390/biomedicines10092262

Cited by 2 publications

(2 citation statements)

References 18 publications

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“…Genome-scale metabolic pathways, genome-environment interactions, the immune response, post-transcriptional regulatory mechanisms, and oncohistones represent aspects of a research field connecting the heritable genetic code to other biological codes. [1][2][3][4][5][6] The aforementioned genetic code is defined precisely as a noninjective map from the 64 codons to the 20 amino acids. Both finite groups and quantum groups have leading roles in modeling this code.…”

Section: Introductionmentioning

confidence: 99%

Group Theory of Messenger RNA Metabolism and Disease

Planat,

Amaral,

Chester

et al. 2024

Gene Expr

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Our recent work has focused on the application of infinite group theory and related algebraic geometric tools in the context of transcription factors and microRNAs. We were able to differentiate between "healthy" nucleotide sequences and disrupted sequences that may be associated with various diseases. In this paper, we extend our efforts to the study of messenger RNA (mRNA) metabolism, showcasing the power of our approach. We investigate (1) mRNA translation in prokaryotes and eukaryotes, (2) polyadenylation in eukaryotes, which is crucial for nuclear export, translation, stability, and splicing of mRNA, (3) microRNAs involved in RNA silencing and post-transcriptional regulation of gene expression, and (4) identification of disrupted sequences that could lead to potential illnesses. To achieve this, we used: (a) infinite (finitely generated) groups f p , with generators representing the r + 1 distinct nucleotides and a relation between them [e.g., the consensus sequence in the mRNA translation (i), the poly (A) tail in item (ii), and the microRNA seed in item (iii)]; (b) aperiodicity theory, which connects healthy groups f p to free groups F r of rank r and their profinite completion ˆr F , and (c) the representation theory of groups f p over the space-time-spin group SL 2 (C), highlighting the role of surfaces with isolated singularities in the character variety. Our approach could potentially contribute to the understanding of the molecular mechanisms underlying various diseases and help develop new diagnostic or therapeutic strategies.

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Section: Introductionmentioning

confidence: 99%

Group Theory of Messenger RNA Metabolism and Disease

Planat,

Amaral,

Chester

et al. 2024

Gene Expr

View full text Add to dashboard Cite

show abstract

“…Genome-scale metabolic pathways [1,2], genome-environment interactions [3], the immune response [4], post-transcriptional regulatory mechanisms [5] and oncohistones [6] represent aspects of a research field connecting the heritable genetic code to other biological codes.…”

Section: Introductionmentioning

confidence: 99%

Group Theory of Messenger RNA Metabolism and Disease

Planat¹,

Amaral²,

Fang³

et al. 2023

Preprint

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Our recent work has focused on the application of infinite group theory and related algebraic geometric tools in the context of transcription factors and microRNAs. We were able to differentiate between “healthy" nucleotide sequences and disrupted sequences that may be associated with various diseases. In this paper, we extend our efforts to the study of messenger RNA metabolism, showcasing the power of our approach. We investigate (i) mRNA translation in prokaryotes and eukaryotes, (ii) polyadenylation in eukaryotes, which is crucial for nuclear export, translation, stability, and splicing of mRNA, (iii) miRNAs involved in RNA silencing and post-transcriptional regulation of gene expression, and (iv) the identification of disrupted sequences that could lead to potential illnesses. To achieve this, we employ (a) infinite (finitely generated) groups fp, with generators representing the r+1 distinct nucleotides and a relation between them [e.g., the consensus sequence in the mRNA translation (i), the poly(A) tail in item (ii), and the miRNA seed in item (iii)], (b) aperiodicity theory, which connects “healthy groups" fp to free groups Fr of rank r and their profinite completion F^r, and (c) the representation theory of groups fp over the space-time-spin group SL2(C), highlighting the role of surfaces with isolated singularities in the character variety. Our approach could potentially contribute to the understanding of the molecular mechanisms underlying various diseases and help develop new diagnostic or therapeutic strategies.

show abstract

mRNA Metabolism in Health and Disease

Abstract: Eukaryotic gene expression involves several interlinked steps, in which messenger RNAs (mRNAs), which code for proteins, are the key intermediates [...]

Cited by 2 publications

References 18 publications

Group Theory of Messenger RNA Metabolism and Disease

Group Theory of Messenger RNA Metabolism and Disease

Group Theory of Messenger RNA Metabolism and Disease

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