Abstract:Eukaryotic mRNAs are derived from precursors synthesised by RNA polymerase II. For 3′‐end formation, precursors are cleaved by an endonuclease, and a poly(A) tail is added. This processing reaction depends on signals in the pre‐mRNA, among them the ‘polyadenylation signal’ AAUAAA. Cleavage and polyadenylation are carried out by a multiprotein complex comprising, in yeast, a minimum of 13 polypeptides, many of which recognise RNA sequence motifs around the polyadenylation site. 3′‐end processing is coupled to t… Show more
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