mRNA expression profile of bronchoalveolar lavage fluid cells from patients with idiopathic pulmonary fibrosis and sarcoidosis

Abstract

Background: Sarcoidosis and idiopathic pulmonary fibrosis (IPF) are two most

Immunopathophysiology and clinical impact of uveitis in inflammatory rheumatic diseases: An update

“…85 Th1 immune polarization has been evidenced both by bronchoalveolar lavage (BAL) studies and indirectly by therapeutic evidence in which Th-1 promoting treatments, such as IFN-α, IFN-γ and IL-2, have been linked with new or relapsing sarcoidal lesions. 86,87 Among the adaptive immune effectors in granulomas formation, also Th17 cells display a key role, both in the classical variant of IL-17-secreting cells and through the Th17.1 phenotype which are IFN-γ-producing lymphocytes. 88 Interestingly, an elevated expression of IL-17 receptor (IL-17R) on CD8+ T cells in peripheral blood has been found in patients with ocular sarcoidosis compared with healthy controls suggesting a role of IL-17 signalling in sarcoidal ocular involvement 89 (Figure 3).…”

“…Th1 immune polarization has been evidenced both by bronchoalveolar lavage (BAL) studies and indirectly by therapeutic evidence in which Th‐1 promoting treatments, such as IFN‐α, IFN‐γ and IL‐2, have been linked with new or relapsing sarcoidal lesions. 86 , 87 …”

Antithrombin III as predictive indicator of survival in idiopathic pulmonary fibrosis (IPF) patients treated with nintedanib: a preliminary study

“…As reported by different authors, 22,26 BAL neutrophil percentage anomalies have prognostic potential for early mortality among IPF patients. However, ATIII concentrations seem to have several advantages as biomarkers of IPF for predicting response to nintedanib therapy and for stratifying patient populations.…”

New allies against old foe: Transcriptomic in idiopathic pulmonary fibrosis

“…Among basic research articles, three outstanding papers were chosen because they were judged innovative, valuable and scientifically relevant. [1][2][3] Among them, the article by Paplińska-Goryca et al entitled "mRNA expression profile of bronchoalveolar lavage fluid cells from patients with idiopathic pulmonary fibrosis (IPF) and sarcoidosis" gained the highest consideration by the ESCI Committee. 3 This is due to the original contribution provided in understanding the complex pathophysiology of these underestimated and misdiagnosed diseases.…”

“…[1][2][3] Among them, the article by Paplińska-Goryca et al entitled "mRNA expression profile of bronchoalveolar lavage fluid cells from patients with idiopathic pulmonary fibrosis (IPF) and sarcoidosis" gained the highest consideration by the ESCI Committee. 3 This is due to the original contribution provided in understanding the complex pathophysiology of these underestimated and misdiagnosed diseases. Some new anti-fibrotic drugs (eg pirfenidone and nintedanib) have shown to significantly slow the decline of respiratory function and improve survival expectation.…”