mRNA Expression of Serotonin Receptors in Cells of the Immune Tissues of the Rat

Antinociceptive effect of peripheral serotonin 5-HT2B receptor activation on neuropathic pain

“…They may correspond to neutrophils involved in the very early stages following peripheral nerve injury [14,48], with a decrease in infiltration by these cells attenuating mechanical allodynia [25]. Other immune cells express the receptor [1], including T lymphocytes [56]. However, their involvement is unlikely, because Tlymphocyte infiltration occurs three days after the nerve lesion and peaks at day 21 [5] well after the observed peak in 5-HT 2B R mRNA levels observed in this study (day 2).…”

Cis-urocanic acid, a sunlight-induced immunosuppressive factor, activates immune suppression via the 5-HT2Areceptor

“…In view of the fact that antigen-presenting cell function is down-regulated after cis-UCA treatment and UV exposure (36), it may be worthwhile to determine whether 5-HT 2A receptor antagonists can block depressed antigen-presenting cell function. Alternatively, T and B cells express 5-HT 2A receptors (37). It is interesting to note that others have demonstrated that treating activated T cells with cis-UCA causes the secretion of IL-10 (38), a cytokine previously found to play a critical role in the immune suppression induced by UV radiation (39).…”

Association between the use of serotonin receptor 2A–blocking antidepressants and joint disorders

“…The 5-HT 2A is linked to cell signaling through the JAK-2/STAT pathway (21), and there are studies suggesting that 5-HT 2A is present on activated T lymphocytes (4,5). One possible explanation, therefore, is that these joint ADRs could be of inflammatory origin.…”

“…Seven main groups of serotonin receptors with their corresponding subgroups have been identified (3). Serotonin receptor subtype 2A (5-HT 2A ) is located on neurons, but also on platelets, vascular smooth muscle (3), and probably also on immune cells (4,5).…”