mRNA expression of antioxidant enzymes (SOD, CAT and GSH-Px) and lipid peroxidative stress in liver of Atlantic salmon (Salmo salar) exposed to hyperoxic water during smoltification

Olsvik, Pål A.; Kristensen, Torstein; Waagbø, Rune; Rosseland, Bjørn Olav; Tollefsen, Knut Erik; Bæverfjord, Grete; Berntssen, Marc H.G.

doi:10.1016/j.cbpc.2005.07.009

Cited by 154 publications

(126 citation statements)

References 30 publications

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“…Similar to these results, after oxytetracycline administration, GST gene expression value increased synchronously serum oxytetracycline level (Figure 2). Different authors reported that there was no correlation between mRNA level and enzyme activity [29,30,31]. We also found similar results compatible with previous reports.…”

Section: Resultssupporting

confidence: 93%

Effects of Oxytetracycline Antibiotic on GST Enzyme Activity and Gene Expression Levels in Rainbow Trout

Çiltaş¹,

Zekeriya²

2016

Fifth International Conference on Advances in Applied Science and Environmental Technology- ASET 2016

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Abstract-In this study, effects of oxytetracycline on glutathione s-transferase enzyme activity and gene expression levels in rainbow trout (Oncorhynchus mykiss) liver were investigated. For this purpose, liver tissues from rainbow trout exposed to oxytetracycline application were collected at third, sixth and 12th hours. The group not exposed to oxytetracycline was assigned as control. While the lowest enzyme activity of GST was at 12th, the highest enzyme activity was observed in control. While compared with the control group, enzyme activity at 12th hour was highly significant (p <0.001), the third and sixth hours groups were significant (p<0.05). The lowest gene expression level was found in 12th group and the highest level was the third. While compared with the control group, difference at the third hour of gene expression level was highly significant (p <0.001), at the sixth and 12th hours groups was not significant. As a result, there was understand that no correlation between gene expression levels and GST enzyme activity.

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Section: Resultssupporting

confidence: 93%

Effects of Oxytetracycline Antibiotic on GST Enzyme Activity and Gene Expression Levels in Rainbow Trout

Çiltaş¹,

Zekeriya²

2016

Fifth International Conference on Advances in Applied Science and Environmental Technology- ASET 2016

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“…Oxidative damage is the result of unbalance between the oxidant and antioxidant processes. Antioxidant defense system plays an important role in the elimination of oxygen radical in vivo, which includes enzymatic scavengers (SOD, CAT and GPX) and some small-molecule antioxidants (GSH, vitamin C and vitamin E) [24]. Here, we investigated the antioxidant defense system involving the index of SOD, CAT, GSH, and so on.…”

Section: Discussionmentioning

confidence: 99%

Acute toxicity and oxidative damage induced by silica nanorattle in vivo

Liu

Tang

et al. 2012

Chin. Sci. Bull.

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Hollow mesoporous nanomaterial is a kind of promising new drug delivery system due to their unique hollow structures. In order to evaluate the toxicity of silica nanorattle (SN) particles in vivo, 40 female mice were used in this study to investigate the acute toxicity and oxidative damage. Mice were intravenously injected with SN suspension in sterile 5% glucose at 40, 80 and 240 mg/kg, respectively. The control group was administrated with equal-volume 5% glucose. Weight, feed intake, hematology analysis, blood biochemical assay and histopathology diagnosis were examined. The activities of SOD, GSH and CAT were measured as well. The results demonstrated that the levels of ALT and AST in the mice treated with 240 mg/kg SN increased significantly as compared with the control group (P<0.05), whereas the contents of BUN and CREA changed unremarkably. The activity of SOD induced by SN in the liver decreased significantly (P<0.05). In summary, this study revealed that liver was the target organ of the SN. It also can be concluded that activity of SOD played an important role in liver injury caused by SN. silica nanorattle, acute toxicity, oxidative stress, superoxide dismutase Citation:Fu C H, Liu T L, Tang F Q, et al. Acute toxicity and oxidative damage induced by silica nanorattle in vivo.

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“…Therefore, protection of gut from ROS mediated induction and progression of pathogenesis is mandatory for better health. The living system has been evolved with endogenous antioxidant defense mechanism to quench leaked and free oxidant species [16]. Dietary intervention of antioxidant rich diet is the most important strategy to modulate antioxidant defense system.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Composition of Extracts Prepared from Dietary Cucurbits and their Cytoprotective Efficacies against Hydrogen Peroxide Induced Oxidative Stress in GI Cell-INT407

Ahmad¹,

Irshad²,

Zafaryab³

et al. 2017

J Plant Biochem Physiol

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mRNA expression of antioxidant enzymes (SOD, CAT and GSH-Px) and lipid peroxidative stress in liver of Atlantic salmon (Salmo salar) exposed to hyperoxic water during smoltification

Cited by 154 publications

References 30 publications

Effects of Oxytetracycline Antibiotic on GST Enzyme Activity and Gene Expression Levels in Rainbow Trout

Effects of Oxytetracycline Antibiotic on GST Enzyme Activity and Gene Expression Levels in Rainbow Trout

Acute toxicity and oxidative damage induced by silica nanorattle in vivo

Phytochemical Composition of Extracts Prepared from Dietary Cucurbits and their Cytoprotective Efficacies against Hydrogen Peroxide Induced Oxidative Stress in GI Cell-INT407

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