mRNA expression level of <i>CDH2, LEP, POSTN, TIMP1</i> and <i>VEGFC</i> modulates 5‑fluorouracil resistance in colon cancer cells

Liu, Tao; Xia, Rongmu; Li, Chenmeng; Chen, Xiaocong; Cai, Xue-Min; Li, Wengang

doi:10.3892/etm.2021.10455

Cited by 9 publications

(6 citation statements)

References 42 publications

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“…Interestingly, we found that CDH2 , a classical cadherin gene that has been previously implicated in cancer cell invasion and metastasis ( 55 , 56 ) to be downregulated in GC patients compared to normal controls. This finding is somewhat unexpected given the established role of CDH2 in promoting cancer cell invasion and metastasis.…”

Section: Discussionmentioning

confidence: 73%

Cadherin dysregulation in gastric cancer: insights into gene expression, pathways, and prognosis

Wang,

Mazzocca,

Gao

2023

J Gastrointest Oncol

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Background The Cadherin gene family holds immense significance in maintaining the integrity and functionality of stomach tissues, playing crucial roles in cell-cell adhesion, cell migration and differentiation. Dysregulation of cadherin expression and function has been closely associated with various gastric diseases, particularly gastric cancer (GC). Understanding the regulation and clinical implications of cadherin genes in GC is essential to improve our knowledge and to identify new potential prognostic markers and therapeutic targets. Methods In this study, we provide an overview on the role of cadherin family genes in GC using bioinformatics analysis. We analyzed the expression, mutational status, and prognostic value of these genes based on available public datasets. Our methodology involved data mining, differential expression analysis, functional enrichment analysis, and survival analysis to explore the association between cadherin gene expression and clinical outcomes in GC patients. Additionally, we investigated the relationship between cadherin expression and immune cell infiltration to gain insights into the tumor microenvironment’s role in GC progression. Results Our bioinformatics analysis revealed significant differential expression of 16 cadherin genes in GC samples compared to normal tissues. Approximately up to 52% of the analyzed cancer samples exhibited genomic alterations in these cadherins, indicating their potential relevance in GC development. Functional enrichment analysis demonstrated that these differentially expressed cadherins were closely associated with critical cellular processes, including cell adhesion and immune-modulation. Remarkably, lower expression levels of most cadherin genes were linked to improved prognosis in GC patients, suggesting their potential importance as valuable prognostic biomarkers. Conclusions The findings deriving from our comprehensive study provide important insights into the dysregulation of cadherin genes in GC and their impact on gene expression, molecular pathways, and prognosis. The associations with clinical outcomes and immune cell infiltration highlight the potential role of cadherin genes as prognostic biomarkers and therapeutic targets in GC.

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Section: Discussionmentioning

confidence: 73%

Cadherin dysregulation in gastric cancer: insights into gene expression, pathways, and prognosis

Wang,

Mazzocca,

Gao

2023

J Gastrointest Oncol

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“…Additionally, GSTM1 gene mutations are associated with colorectal cancer risk [19]. Leptin (LEP), the most famous adipokine highly expressed in colorectal cancer is related to the sensitivity of chemotherapy drug 5uorouracil (5-FU) [20,21]. Tissue metalloprotease inhibitor I (TIMP1) has been widely con rmed as a prognostic biomarker for colon cancer.…”

Section: Discussionmentioning

confidence: 99%

Deciphering a hydrogen sulfide-related signature to supervise prognosis and therapeutic response in colon adenocarcinoma

Chen

Zhang

2023

Preprint

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Background: Hydrogen sulfide (H2S) is a critical molecule that participates in various molecular, physiological, and pathophysiological processes in biological systems. Emerging evidence has revealed that H2S is implicated in the progression of colon cancer and immune escape. Against this backdrop, the present study aimed to construct a prognostic risk feature for colon adenocarcinoma (COAD) by leveraging H2S-related genes (HSRG). Methods: Transcriptomic data and corresponding clinical-pathological information of colon cancer were obtained from TCGA and GEO databases. Univariate Cox regression analysis was employed to assess the prognostic relevance of HSRG. Consensus clustering was utilized to perform molecular subtyping of COAD, followed by comparison of immune cell infiltration, drug sensitivity, and immune therapy response between subtypes. Differential expression gene and gene set enrichment analyses were conducted between subtypes. Univariate, lasso, and multivariate Cox regression analyses were applied to construct a prognostic model derived from HSRG. A nomogram model for predicting COAD prognosis was constructed and evaluated. Results: In this study, we identified 12 HSRGs that were associated with COAD prognosis. Consensus clustering analysis revealed 3 COAD molecular subtypes that exhibited significant differences in terms of prognosis, tumor immune cell infiltration, drug sensitivity, and immune therapy response. Gene set enrichment analysis demonstrated that immunoregulatory processes were significantly suppressed in the poor-prognosis subtype while Wnt-related pathways and processes were significantly upregulated. Based on the differentially expressed genes between subtypes, we constructed a risk model comprising 11 genes that effectively distinguished high-risk patients from low-risk patients with significant associations with patient survival outcomes, drug treatment, pathological staging, and T staging. The HSRG-derived risk feature was an independent prognostic factor for COAD in drug treatment and pathological staging and could be integrated into a nomogram for prognosis prediction. Calibration curve, receiver operating characteristic curve (ROC), and decision curve analysis demonstrated excellent performance of the nomogram in evaluating COAD prognosis. Conclusion: Our study systematically assessed the prognostic significance of HSRG in COAD, identified HSRG-based molecular subtypes and risk features, and highlighted their potential utility in predicting prognosis and treatment response.

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“…Chemotherapy is an important cancer treatment modality, and its effectiveness is challenging ( 75 ). Inherent or adventitious drug resistance to chemotherapy can result in poor treatment outcomes and tumor relapse, a major cause of treatment failure ( 76 ). The expression of ANXA1 plays a key role in chemotherapy resistance, and regulating ANXA1 expression represents a possible strategy for overcoming resistance.…”

Section: Anxa1mentioning

confidence: 99%

Annexin A1 affects tumor metastasis through epithelial-mesenchymal transition: a narrative review

Zheng¹,

Li²,

Wang³

et al. 2022

Transl Cancer Res

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Background and Objective: Annexin A1 (annexin I, ANXA1), the first discovered member of the annexin superfamily, plays important roles in tumor development, invasion, metastasis, apoptosis and drug resistance based on tumor type-specific patterns of expression. The acquisition of the epithelialmesenchymal transition (EMT) characteristics is an essential mechanism of metastasis because they increase the mobility and invasiveness of cancer cells. Cancer invasion and metastasis remain major health problems worldwide. Elucidating the role and mechanism of ANXA1 in the occurrence of EMT will help advance the development of novel therapeutic strategies. Hence, this review aims to attract everyone's attention to the important role of ANXA1 in tumors and provide new ideas for clinical tumor treatment. Methods:The PubMed database was mainly used to search for various English research papers and reviews related to the role of ANXA1 in tumors and EMT published from November 1994 to April 2022. The search terms used mainly include ANXA1, EMT, tumor, cancer, carcinoma, and mechanism.

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mRNA expression level of CDH2, LEP, POSTN, TIMP1 and VEGFC modulates 5‑fluorouracil resistance in colon cancer cells

Cited by 9 publications

References 42 publications

Cadherin dysregulation in gastric cancer: insights into gene expression, pathways, and prognosis

Cadherin dysregulation in gastric cancer: insights into gene expression, pathways, and prognosis

Deciphering a hydrogen sulfide-related signature to supervise prognosis and therapeutic response in colon adenocarcinoma

Annexin A1 affects tumor metastasis through epithelial-mesenchymal transition: a narrative review

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