mRNA expression and localization of bNOS, eNOS and iNOS in human cervix at preterm and term labour

Törnblom, Susanne Abelin; Maul, Holger; Klimaviciute, Aurelija; Garfield, Robert E.; Byström, Birgitta; Malmström, Anders; Ekman-Ordeberg, Gunvor

doi:10.1186/1477-7827-3-33

Cited by 47 publications

(11 citation statements)

References 48 publications

(67 reference statements)

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“…The majority of neonates born to recovered mothers who showed elevated levels of CXCL8 were born by vaginal delivery (Fig. 2d), known to elevate several cytokines 22 . However, there were still notable, albeit insignificant (P = 0.07, unpaired two-tailed Kolmogorov-Smirnov test), increases of CXCL8 in neonates born via cesarean section (CS) in the R/O group, compared to the R group, suggesting this was possibly a neonatal response to maternal SARS-CoV-2 infection.…”

Section: Resultsmentioning

confidence: 99%

The legacy of maternal SARS-CoV-2 infection on the immunology of the neonate

et al. 2021

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Despite extensive studies into severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the effect of maternal infection on the neonate is unclear. To investigate this, we characterized the immunology of neonates born to mothers with confirmed SARS-CoV-2 infection during pregnancy. Here we show that maternal SARS-CoV-2 infection affects the neonatal immune system. Despite similar proportions of B cells, CD4 + T cells and CD8 + T cells, increased percentages of natural killer cells, Vδ2 + γδ T cells and regulatory T cells were detected in neonates born to mothers with recent or ongoing infection compared with those born to recovered or uninfected mothers. Increased plasma cytokine levels were also evident in neonates and mothers within the recent or ongoing infection group. Cytokine functionality was enhanced in neonates born to SARS-CoV-2-exposed mothers, compared to those born to uninfected mothers. In most neonates, this immune imprinting was nonspecific, suggesting vertical transmission of SARS-CoV-2 is limited, a finding supported by a lack of SARS-CoV-2-specific IgM in neonates despite maternal IgG transfer.

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Section: Resultsmentioning

confidence: 99%

The legacy of maternal SARS-CoV-2 infection on the immunology of the neonate

et al. 2021

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“…Normally, in the late pregnancy prior to early phases of delivery at full term pregnancy, the cervix undergoes cervical ripening depending on biochemical changes, such as reduction of collagen synthesis and increased collagenase activity, which leads to delivery of the fetus [ 18 , 19 ]. In cases of preterm labor the cervical changes like cervical softening associated with painless dilatation, and shortening is explained by increased synthesis of interleukin (IL)-6 amd IL-8 and prostaglandin synthesis, and monocyte chemotactic protein I in absence of infection [ 20 , 21 ]. Asymptomatic pregnant women more commonly in the second than in the first trimester have a prediction to preterm labor in cases with abnormal sonographic cervical findings including the length of cervix (distance between the triangular area of echo density at the external cervical os and the V shaped notch at the internal one) [ 22 , 23 ].…”

Section: Discussionmentioning

confidence: 99%

Comparative Evaluation of Arabin Pessary and Cervical Cerclage for the Prevention of Preterm Labor in Asymptomatic Women with High Risk Factors

Tsikouras

Anastasopoulos

Maroulis

et al. 2018

IJERPH

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Objective: Preterm labor is one of the most significant obstetric problems associated with high rate of actual and long-term perinatal complications. Despite the creation of scoring systems, uterine activity monitoring, cervical ultrasound and several biochemical markers, the prediction and prevention of preterm labor is still a matter of concern. The aim of this study was to examine cervical findings for the prediction and the comparative use of Arabin pessary or cerclage for the prevention of preterm birth in asymptomatic women with high risk factors for preterm labor. Material and methods: The study group was composed of singleton pregnancies (spontaneously conceived) with high risk factors for preterm labor. Cervical length, dilatation of the internal cervical os and funneling, were estimated with transvaginal ultrasound during the first and the second trimesters of pregnancy. Results: Cervical funneling, during the second trimester of pregnancy, was the most significant factor for the prediction of preterm labor. The use of Arabin cervical pessary was found to be more effective than cerclage in the prolongation of pregnancy. Conclusion: In women at risk for preterm labor, the detection of cervical funneling in the second trimester of pregnancy may help to predict preterm labor and to apply the appropriate treatment for its prevention. Although the use of cervical pessary was found to be more effective than cerclage, more studies are needed to classify the effectiveness of different methods for such prevention.

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“…This parallel use of both parametric and non-parametric statistics techniques is not objected by recent studies in various scientific fields (e.g. Törnblom et al, 2005;Xu et al, 2003). Furthermore, according to Vickers (2005) there seems to be no obvious and universal manner in which non-parametric methods become significantly superior over their parametric cousins once the data distributions shift from normal.…”

Section: Methodsmentioning

confidence: 99%

Benchmarking the competitiveness of industrial sectors

Bilalis

Alvizos

Tsironis

et al. 2007

Int J Productivity & Perf Mgmt

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Purpose -The paper aims to present a clear methodological path for assessing the competitiveness of a specific industrial sector with the use of the Industrial Excellence Award (IEA) model. The paper introduces the concepts evaluated by the IEA model and addresses the ways with which varied management data may be analyzed in order to provide useful insights for improvement in industrial processes such as new product and process development, supply chain management, strategy formulation and deployment. Design/methodology/approach -Sixty European textile companies provided information concerning their business processes over the course of three years in accordance with the Industrial Excellence Award (IEA) model developed by INSEAD Business Schools. Subsequently, the textile industry companies were compared with 73 excellence-driven European manufacturers which either won or distinguished themselves in the award competition during the same time period. The management information from both datasets was treated with the proper statistical tools (according to their nature) in order to attain secure and minimally biased conclusions. Findings -The benchmarking process revealed the areas in which the textile sector was lagging behind the excellence-driven manufacturers. Furthermore, it detected their differences in specific measures of industrial management and business mentality. On a theoretical level, the analysis verified the general reliability of the IEA model's scales, aiming at assessing abstract management constructs while fine tuning them.Research limitations/implications -The thorough inspection of the textile companies' performance attributes and characteristics has identified many of the sector's shortcomings that merit further investigation. Practical implications -The results of the analysis served as valuable feedback to textile managers aiming at bettering their industrial processes in many ways, such as benchmarking their performance against their sector or other sectors, and observing trends that managers from other sectors are putting effort into in order to improve their performance. Originality/value -The paper provides a clear-cut methodology for the understanding and statistical analysis of multifaceted industrial management data included in excellence models.

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mRNA expression and localization of bNOS, eNOS and iNOS in human cervix at preterm and term labour

Cited by 47 publications

References 48 publications

The legacy of maternal SARS-CoV-2 infection on the immunology of the neonate

The legacy of maternal SARS-CoV-2 infection on the immunology of the neonate

Comparative Evaluation of Arabin Pessary and Cervical Cerclage for the Prevention of Preterm Labor in Asymptomatic Women with High Risk Factors

Benchmarking the competitiveness of industrial sectors

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