mRNA cytokine profile in peripheral blood cells from chronic hepatitis C virus (HCV)-infected patients: effects of interferon-alpha (IFN-α) treatment

Shapiro, Sarah; Gershtein, Vladimir; Elias, Nizar; Zuckerman, Eli; Salman, Nabia; Lahat, Nitza

doi:10.1046/j.1365-2249.1998.00693.x

Cited by 43 publications

(26 citation statements)

References 36 publications

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“…Relevant to HCV, HCV-specific IL-10 + CD8 T-cell frequency in the liver correlated inversely to histological activity (16,39). Additionally, changes in serum or Tcell IL-10 levels have been associated with the efficacy of antiviral therapy in some studies (32,34,(40)(41)(42)(43)(44)(45)(46).…”

Section: Discussionmentioning

confidence: 99%

Peripheral virus-specific T-cell interleukin-10 responses develop early in acute hepatitis C infection and become dominant in chronic hepatitis

Kaplan¹,

Ikeda²,

Li³

et al. 2008

Journal of Hepatology

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Section: Discussionmentioning

confidence: 99%

Peripheral virus-specific T-cell interleukin-10 responses develop early in acute hepatitis C infection and become dominant in chronic hepatitis

Kaplan¹,

Ikeda²,

Li³

et al. 2008

Journal of Hepatology

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“…Other studies have shown that the 2 infectious agents have similar adverse effects on the immune system, as manifested by their action on cytokine production by T-helper 1 and T-helper 2 cells. 36,37 Periportal fibrosis was found earlier to be a typical pathologic feature in advanced schistosomiasis, 38,39 but bilharzial hepatic changes were suggested to be partly reversible. 40 Infection with HCV was found to cause a more severe and irreversible form of liver damage than schistosomal infection.…”

Section: Discussionmentioning

confidence: 99%

Effect of schistosomiasis and hepatitis on liver disease.

Halim

Garry²,

Dash³

et al. 1999

The American Journal of Tropical Medicine and Hygiene

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Abstract. Infection with hepatitis C virus (HCV) has become the most important public health problem in Egypt. In Egypt, viral hepatitis along with infection with Schistosoma mansoni is the major cause of chronic liver disease and liver cirrhosis. Although HCV infection is highly prevalent in Egypt, very little information is available on the distribution of the different genotypes of HCV. Our aims in this study were first to determine the prevalence of viral and parasite infections in patients with chronic liver disease and then to assess the distribution of HCV genotypes in these patients. In the present study, 151 individuals (50 with chronic liver disease, 51 with chronic diseases of organs other than the liver, and 50 apparently healthy persons) were investigated. The last 2 groups served as control groups. These individuals were subjected to routine liver function tests and detection of serum antibodies to bilharziasis, hepatitis B surface antigen (HBsAg), and HCV. Furthermore, the presence of hepatitis G virus (HGV) and HCV in the serum samples were tested for by a reverse transcription polymerase chain reaction (RT-PCR). Prevalence of different genotypes of HCV in patients positive for HCV were determined by RT-PCR using type-specific primers. Results of the study revealed that 84, 74, 12, and 20% of patients with chronic liver disease were positive for Schistosoma mansoni, HCV, HBsAg, and HGV, respectively, as compared to 51, 43.1, 2, and 4% of patients with other chronic diseases and 22, 6, 0, and 0% of apparently healthy individuals. One hundred percent of patients with chronic liver disease, 72.5% of those with other diseases, and 26% of normal controls were shown to have at least one of the studied infectious agents. Two or more of the agents were highly coincident in patients with chronic liver disease. In Egypt, HCV genotype 4a is highly prevalent, where it contributed 85% of the tested samples in comparison to 10, 2.5, and 2.5% for subtypes 1b, 2a, and 3a, respectively. In conclusion, these results suggest that in Egypt, HCV along with schistosomal parasite infection is the major risk factor for chronic liver disease. In most Egyptian patients, HCV genotype 4 is highly prevalent.Hepatitis C virus (HCV) has been identified as the major causative agent of posttransfusion and sporadic communityacquired non-A, non-B hepatitis (NANBH). 1,2 Hepatitis C virus is a single-stranded RNA virus closely related to pestiviruses and flaviviruses. The viral RNA has 2 short nontranslational regions at the 5Ј and 3Ј ends enclosing a single large open reading frame. Individual proteins, the core (C), envelope (E1 and E2), and nonstructural proteins (NS1-NS5) 3,4 are cleaved from the polyprotein by host and viral protease. Hepatitis C virus is highly prevalent in Egypt, where its antibodies were detected in 10-30% of the Egyptian population. [5][6][7][8] Recently, HCV infection was concluded to be the main cause of chronic liver disease in Egypt, where this infection is largely associated with schistosomiasis (Gandi...

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“…4 There is growing evidence that cytokine expression is also linked to HCV treatment response, with lower baseline levels generally correlated with virologic response. [4][5][6][7][8][9][10][11][12][13] Thus, certain cytokines may be useful as easily measured, predictive markers of treatment response.…”

Section: Introductionmentioning

confidence: 99%

Effects of HCV Treatment on Cytokine Expression During HCV/HIV Coinfection

Blackard

Kang

Sherman

et al. 2006

Journal of Interferon & Cytokine Research

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There is growing evidence that cytokine expression is linked to hepatitis C virus (HCV) pathogenesis and treatment response rates among HCV-monoinfected persons. However, because of the profound effects of human immunodeficiency virus (HIV) coinfection on HCV, it is not clear if these observations are also true for HCV/HIV-coinfected individuals. Serum expression of the proinflammatory cytokines interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α) and the fibrogenic cytokine transforming growth factor-β1 (TGF-β1) were measured in HCV/HIVcoinfected persons at baseline and at week 24 of HCV therapy. Higher levels of IL-8 and TGF-β were demonstrated among nonwhite subjects at baseline. Increases in TNF-α and IL-8 expression were found at week 24 of HCV therapy, suggesting that enhanced proinflammatory cytokine production may occur during HCV treatment. However, cytokine levels were not predictive of HCV virologic, biochemical, or histologic response. Although previous studies conducted among HCV-monoinfected individuals have suggested that cytokine levels could predict the virologic response to therapy, no such associations were observed among HCV/HIV-coinfected persons, suggesting that they may respond differently to treatment than do their HCV-monoinfected counterparts.

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mRNA cytokine profile in peripheral blood cells from chronic hepatitis C virus (HCV)-infected patients: effects of interferon-alpha (IFN-α) treatment

Cited by 43 publications

References 36 publications

Peripheral virus-specific T-cell interleukin-10 responses develop early in acute hepatitis C infection and become dominant in chronic hepatitis

Peripheral virus-specific T-cell interleukin-10 responses develop early in acute hepatitis C infection and become dominant in chronic hepatitis

Effect of schistosomiasis and hepatitis on liver disease.

Effects of HCV Treatment on Cytokine Expression During HCV/HIV Coinfection

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