MRI-visible Dilated Perivascular Space in the Brain by Age: The Human                     Connectome Project

Kim, Hyun Gi; Shin, Na‐Young; Nam, Yoonho; Yun, Eunkyeong; Yoon, Uicheul; Lee, Hye Sun; Ahn, Kook Jin

doi:10.1148/radiol.213254

Cited by 26 publications

(58 citation statements)

References 27 publications

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“…PVS enlargement is conventionally detected and quantified on the T2W image (Ramirez et al, 2016;Ballerini et al, 2018). A recent cross-sectional study of 1789 healthy subjects aged 8-100 years revealed a biphasic PVS volume change with age in the basal ganglia and the WM, slightly decreasing until the mid-30s and increasing afterwards (Kim et al, 2022), which is very similar to the trends seen in our study (Fig.2). However, unlike CSFF, there was a considerable variation in PVS volume fraction, especially in the older subjects (Kim et al, 2022).…”

Section: Discussionsupporting

confidence: 91%

“…A recent cross-sectional study of 1789 healthy subjects aged 8-100 years revealed a biphasic PVS volume change with age in the basal ganglia and the WM, slightly decreasing until the mid-30s and increasing afterwards (Kim et al, 2022), which is very similar to the trends seen in our study (Fig.2). However, unlike CSFF, there was a considerable variation in PVS volume fraction, especially in the older subjects (Kim et al, 2022). Since this approach is not capable of detecting PVS much smaller than the voxel size (approximately 1 mm), future works are needed to study the association between the T2W-visible PVS load and CSFF in the same cohort.…”

Section: Discussionsupporting

confidence: 91%

“…2). However, unlike CSFF, there was a considerable variation in PVS volume fraction, especially in the older subjects (Kim et al, 2022). Since this approach is not capable of detecting PVS much smaller than the voxel size (approximately 1 mm), future works are needed to study the association between the T2Wvisible PVS load and CSFF in the same cohort.…”

Section: Discussionmentioning

confidence: 99%

“…Advanced imaging techniques have shown that PVS is a key component of the glymphatic system for brain waste removal (Weller et al, 1992;Iliff et al, 2012;Nedergaard, 2013;Taoka et al, 2017). PVS dilation occurs in normal aging (Kim et al, 2022) and has been established as an early imaging marker of cerebral small vessel disease (Wardlaw et al, 2013), cerebral amyloid angiopathy (van Veluw et al, 2016;Charidimou et al, 2017), and Alzheimer’s disease (Banerjee et al, 2017;Boespflug et al, 2018). Traditionally, visible PVS enlargement on T2-weighted (T2W) image is assessed by counting or segmenting hyperintense punctate foci in the white matter (WM) centrum semiovale and the basal ganglia (Potter et al, 2015;Ramirez et al, 2016;Ballerini et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

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Brain tissue cerebrospinal fluid fraction increases quadratically in normal aging

Zhou¹,

Li²,

Sweeney³

et al. 2023

Preprint

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Background and Purpose: Our objective was to apply multi-compartment T2 relaxometry in cognitively normal individuals aged 20-80 years to study the effect of aging on the parenchymal cerebrospinal fluid fraction (CSFF), a measure of the microscopic-scale CSF space. Materials and Methods: A total of 66 volunteers (age range, 22-80 years) were enrolled. Voxel-wise maps of short-T2 myelin water fraction (MWF), intermediate-T2 intra/extra-cellular water fraction (IEWF), and long-T2 CSFF were obtained using fast acquisition with spiral trajectory and adiabatic T2prep (FAST-T2) sequence and three-pool non-linear least squares fitting. Multiple linear regression analysis with correction for multiple comparisons was performed to study the association between age and regional MWF, IEWF, and CSFF measurements, adjusting for sex and region of interest (ROI) volume. The cerebral white matter (WM), cerebral cortex, and subcortical deep gray matter (GM) were considered as ROIs. In each model, a quadratic term for age was tested using an ANOVA test. A Spearman's correlation between the normalized lateral ventricle volume, a measure of organ-level CSF space, and the regional CSFF, a measure of tissue-level CSF space, was computed. Results: In the multiple regression analysis, we found a statistically significant quadratic relationship between age and regional CSFF for all three ROIs (all p-values < 0.001). A statistically significant quadratic relationship with age was also found for MWF in the deep GM (p = 0.004) and IEWF in the cortex (p = 0.012). There was a statistically significant linear relationship between age and regional IEWF in the cerebral WM (p = 0.006) and deep GM (p = 0.002). In the univariate correlation analysis, the normalized lateral ventricle volume was found to correlate moderately with the regional CSFF measurement in the cerebral WM (ρ = 0.43, p < 0.001), cortex (ρ = 0.43, p < 0.001), and deep GM (ρ = 0.49, p < 0.001). Conclusion: Brain tissue water residing in different water compartments shows complex changing patterns with age. Parenchymal CSFF, a biomarker of microscopic-scale CSF-like water, shows a quadratic increase in both GM and WM, starting approximately at the age of 50.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Brain tissue cerebrospinal fluid fraction increases quadratically in normal aging

Zhou¹,

Li²,

Sweeney³

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…provide each individual information of connectivity of his own brain, and may not reflect his actual situation. It can vary with age, gender, body mass index and neurological diseases [41][42][43][44][45][46].…”

Section: Normative Connectome and The Human Connectome Project (Hcp)mentioning

confidence: 99%

Perspective Chapter: Functional Human Brain Connectome in Deep Brain Stimulation (DBS) for Parkinson’s Disease (PD)

Chan¹

2023

Advances in Electroencephalography and Brain Connectome

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Historically, the success of DBS depends on the accuracy of electrode localization in neuroanatomical structures. With time, diffusion-weighted magnetic resonance imaging (MRI) and functional MRI have been introduced to study the structural connectivity and functional connectivity in patients with neurodegenerative disorders such as PD. Unlike the traditional lesion-based stimulation theory, this new network stimulation theory suggested that stimulation of specific brain circuits can modulate the pathological network and restore it to its physiological state, hence causing normalization of human brain connectome in PD patients. In this review, we discuss the feasibility of network-based stimulation and the use of connectomic DBS in PD.

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Enlarged perivascular spaces in patients with migraine: a case–control study based on 3T MRI

Yuan,

Li,

Tang

et al. 2023

Ann Clin Transl Neurol

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Objective To explore whether MRI‐visible enlarged perivascular spaces (EPVS) are associated with migraine and may serve as a predictor of migraine. Then further explore its correlation with migraine chronification. Methods A total of 231 participants (healthy control [HC] = 57, episodic migraine [EM] = 59, chronic migraine [CM] = 115) were included in this case–control study. A 3T MRI device and the validated visual rating scale were used to assess the grades of EPVS in centrum semiovale (CSO), midbrain (MB), and basal ganglia (BG). Comparisons between the two groups were made using the chi‐square or Fisher's exact tests to initially determine whether high‐grade EPVS were associated with migraine and migraine chronification. A multivariate logistic regression model was constructed to further investigate the role of high‐grade EPVS in migraine. Results The prevalence of high‐grade EPVS in CSO and MB were significantly higher in patients with migraine than in HCs (CSO: 64.94% vs. 42.11%, P = 0.002; MB: 55.75% vs. 29.82%, P = 0.001). Subgroup analysis showed no statistical difference between patients with EM and CM (CSO: 69.94% vs. 62.61%, P = 0.368; MB: 50.85% vs. 58.26%, P = 0.351). Individuals with high‐grade EPVS in CSO (odds ratio [OR]: 2.324; 95% confidence interval [CI]: 1.136–4.754; P = 0.021) and MB (OR: 3.261; 95% CI: 1.534–6.935; P = 0.002) were more likely to suffer from migraine. Interpretation This case–control study showed that high‐grade EPVS in CSO and MB in clinical practice with the underlying mechanism of dysfunction of the glymphatic system could be a predictor of migraine, but no significant correlation had been found with migraine chronification.

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MRI-visible Dilated Perivascular Space in the Brain by Age: The Human Connectome Project

Cited by 26 publications

References 27 publications

Brain tissue cerebrospinal fluid fraction increases quadratically in normal aging

Brain tissue cerebrospinal fluid fraction increases quadratically in normal aging

Perspective Chapter: Functional Human Brain Connectome in Deep Brain Stimulation (DBS) for Parkinson’s Disease (PD)

Enlarged perivascular spaces in patients with migraine: a case–control study based on 3T MRI

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