MRI signal changes of the bone marrow in HIV-infected patients with lipodystrophy: correlation with clinical parameters

García, A.; Milinkovic, Ana; Tomás, Xavier; Ríos, José; Pérez, Iñaki; Vidal-Sicart, Sergi; Pomés, Jaume; Amo, Montserrat del; Mallolas, Josép

doi:10.1007/s00256-011-1147-x

Cited by 12 publications

(6 citation statements)

References 20 publications

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“…This finding is confirmed by the PDFF map that shows almost no fat present in this region (hematopoietic marrow in the spine typically contains at least 46% to 66% fat). A high prevalence of serous‐like patterns in individuals with HIV has been previously reported . Therefore, these findings emphasize the need for high‐resolution fat fraction mapping.…”

Section: Future Research Directionssupporting

confidence: 64%

“…A high prevalence of serous-like patterns in individuals with HIV has been previously reported. 168 Therefore, these findings emphasize the need for highresolution fat fraction mapping. Upper rows are a high-resolution trabecular bone image (left column), an R 2 * map (middle column), and a local fieldmap after removal of background fields (right column) of the distal tibia in a healthy subject.…”

Section: Future Research Directionsmentioning

confidence: 99%

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Quantitative MRI and spectroscopy of bone marrow

Karampinos

Ruschke

Dieckmeyer

et al. 2017

Magnetic Resonance Imaging

202

241

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Bone marrow is one of the largest organs in the human body, enclosing adipocytes, hematopoietic stem cells, which are responsible for blood cell production, and mesenchymal stem cells, which are responsible for the production of adipocytes and bone cells. Magnetic resonance imaging (MRI) is the ideal imaging modality to monitor bone marrow changes in healthy and pathological states, thanks to its inherent rich soft‐tissue contrast. Quantitative bone marrow MRI and magnetic resonance spectroscopy (MRS) techniques have been also developed in order to quantify changes in bone marrow water–fat composition, cellularity and perfusion in different pathologies, and to assist in understanding the role of bone marrow in the pathophysiology of systemic diseases (e.g. osteoporosis). The present review summarizes a large selection of studies published until March 2017 in proton‐based quantitative MRI and MRS of bone marrow. Some basic knowledge about bone marrow anatomy and physiology is first reviewed. The most important technical aspects of quantitative MR methods measuring bone marrow water–fat composition, fatty acid composition, perfusion, and diffusion are then described. Finally, previous MR studies are reviewed on the application of quantitative MR techniques in both healthy aging and diseased bone marrow affected by osteoporosis, fractures, metabolic diseases, multiple myeloma, and bone metastases. Level of Evidence: 3 Technical Efficacy: Stage 2J. Magn. Reson. Imaging 2018;47:332–353.

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Section: Future Research Directionssupporting

confidence: 64%

Section: Future Research Directionsmentioning

confidence: 99%

Quantitative MRI and spectroscopy of bone marrow

Karampinos

Ruschke

Dieckmeyer

et al. 2017

Magnetic Resonance Imaging

202

241

View full text Add to dashboard Cite

show abstract

“…Other conditions include infiltrative malignancy treated by chemo-radiation/bone marrow transplant, Paget's disease in acute-subacute phases, and serous marrow lesions observed in HIV-infected patients having lipodystrophy syndrome treated with highly active antiretroviral therapy. [575859] These conditions can be highly heterogeneous and difficult to distinguish from active malignancy. However, there are usually small islands of microscopic fatty marrow in successfully treated lesions.…”

Section: Category III Lesionsmentioning

confidence: 99%

Bone marrow lesions: A systematic diagnostic approach

Grande

Farahani

Carrino

et al. 2014

Indian Journal of Radiology and Imaging

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Bone marrow lesions on magnetic resonance (MR) imaging are common and may be seen with various pathologies. The authors outline a systematic diagnostic approach with proposed categorization of various etiologies of bone marrow lesions. Utilization of typical imaging features on conventional MR imaging techniques and other problem-solving techniques, such as chemical shift imaging and diffusion-weighted imaging (DWI), to achieve accurate final diagnosis has been highlighted.

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“…During brain MRI reading, attention should also be paid to the cranial bone and extracranial lesions, particularly those involving the bone marrow, parotid glands, lymphoid tissue, and skin. HIV causes chronic inflammation and hyperplasia of the bone marrow [ 104 – 106 ], both of which could result in a decreased signal on T1-weighted images, making the bone marrow appear “gray” [ 107 ]. In addition, HIV and ART both increase the risk of osteoporosis [ 108 ].…”

Section: Extra-cns Findings On Brain Mrimentioning

confidence: 99%

MRI imaging features of HIV-related central nervous system diseases: diagnosis by pattern recognition in daily practice

et al. 2021

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With the advent of antiretroviral therapy (ART), the prognosis of people infected with human immunodeficiency virus (HIV) has improved, and the frequency of HIV-related central nervous system (CNS) diseases has decreased. Nevertheless, mortality from HIV-related CNS diseases, including those associated with ART (e.g., immune reconstitution inflammatory syndrome) remains significant. Magnetic resonance imaging (MRI) can improve the outlook for people with HIV through early diagnosis and prompt treatment. For example, HIV encephalopathy shows a diffuse bilateral pattern, whereas progressive multifocal leukoencephalopathy, HIV-related primary CNS lymphoma, and CNS toxoplasmosis show focal patterns on MRI. Among the other diseases caused by opportunistic infections, CNS cryptococcosis and CNS tuberculosis have extremely poor prognoses unless diagnosed early. Immune reconstitution inflammatory syndrome shows distinct MRI findings from the offending opportunistic infections. Although distinguishing between HIV-related CNS diseases based on imaging alone is difficult, in this review, we discuss how pattern recognition approaches can contribute to their early differentiation.

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MRI signal changes of the bone marrow in HIV-infected patients with lipodystrophy: correlation with clinical parameters

Cited by 12 publications

References 20 publications

Quantitative MRI and spectroscopy of bone marrow

Quantitative MRI and spectroscopy of bone marrow

Bone marrow lesions: A systematic diagnostic approach

MRI imaging features of HIV-related central nervous system diseases: diagnosis by pattern recognition in daily practice

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