MRI radiomics captures early treatment response in patient-derived organoid endometrial cancer mouse models
Heidi Espedal,
Kristine E. Fasmer,
Hege F. Berg
et al.
Abstract:BackgroundRadiomics can capture microscale information in medical images beyond what is visible to the naked human eye. Using a clinically relevant mouse model for endometrial cancer, the objective of this study was to develop and validate a radiomic signature (RS) predicting response to standard chemotherapy.MethodsMice orthotopically implanted with a patient-derived grade 3 endometrioid endometrial cancer organoid model (O-PDX) were allocated to chemotherapy (combined paclitaxel/carboplatin, n=11) or saline/… Show more
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