MRI quantification of rheumatoid arthritis: Current knowledge and future perspectives

Boesen, Mikael; Østergaard, Mikkel; Cimmino, Marco A.; Kubassova, Olga; Jensen, Karl Erik; Bliddal, Henning

doi:10.1016/j.ejrad.2009.04.048

Cited by 58 publications

(39 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[1][2][3] A direct measurement of the AEP provides important clinical information with respect to the extent of the disease and may evaluate inflammatory changes more sensitively than the scoring system. The method for estimating AEP by manual outlining is regarded as a leading direct measurement but requires interpretation by experienced rheumatologists or radiologists.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3] The amount of synovial membrane (pannus) is probably related to disease activity and severity, and a reliable quantification may be useful in the assessment of patients with RA and as a therapy evaluation. [4][5][6] The Outcome Measures in Rheumatology Clinical Trials (OMERACT) RA-MRI scoring (RAMRIS) system has been extensively utilized as the gold standard of MR scoring for inflammatory and destructive changes in the hands and wrists of patients with RA.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Accurate quantitative assessment of synovitis in rheumatoid arthritis using pixel-by-pixel, time–intensity curve shape analysis

Sakashita¹,

Kamishima²,

Kobayashi³

et al. 2016

BJR

View full text Add to dashboard Cite

Objective: To improve on the reproducibility and sensitivity of the assessment of patients with rheumatoid arthritis (RA), two semi-automated measurement methods of the area of enhancing pannus (AEP), based on thresholding (AEP_THRES) and pixel-by-pixel timeintensity curve analysis (AEP_TIC), were evaluated as an alternative for the gold-standard manual contouring method (AEP_MANUAL). Methods: 8 patients (7 females and 1 male) with RA of the wrist or finger joints participated in the study. A threedimensional contrast-enhanced dynamic sequence was used at 3 T. After identifying the most relevant timeintensity curve (TIC) shape in terms of synovitis by comparing with the synovitis score using the RA-MRI scoring system, three different approaches for measuring the AEP were performed. Spearman's test of rank correlation was used to compare AEPs via two semi-automated methods (AEP_THRES and AEP_TIC) against manual segmentation (AEP_MANUAL) in the entire hand region as well as the wrist and the finger regions. Results: The TIC shape of "washout after fast initial enhancement" had excellent correlation with synovitis score (r 5 0.809). The correlation coefficient between AEP_TIC and AEP_MANUAL was evaluated to be better than that of AEP_THRES and AEP_MANUAL in the wrist region (AEP_THRES: r 5 0.716, AEP_TIC: r 5 0.815), whereas these were of comparable accuracy for the entire hand and the finger regions. Conclusion: This study suggests that TIC analysis may be an alternative to manual contouring for pannus quantification and provides important clinical information of the extent of the disease in patients with RA. Advances in knowledge: TIC shape analysis can be applied for new quantitative assessment for RA synovitis in the wrist.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Accurate quantitative assessment of synovitis in rheumatoid arthritis using pixel-by-pixel, time–intensity curve shape analysis

Sakashita¹,

Kamishima²,

Kobayashi³

et al. 2016

BJR

View full text Add to dashboard Cite

show abstract

“…Dynamic contrast enhancement (DCE)-MRI is an imaging technique where MR images are acquired sequentially over the same slices over time following an injection of Gadolinium contrast agent [3]. It is considered a valuable modality for quantitative reproducible assessment of the inflamed synovium in patients with RA [4].…”

Section: Introductionmentioning

confidence: 99%

Evaluating automated dynamic contrast enhanced wrist 3T MRI in healthy volunteers: One-year longitudinal observational study

Rastogi

Kubassova²,

Krasnosselskaia

et al. 2013

European Journal of Radiology

Self Cite

View full text Add to dashboard Cite

“…There is increasing evidence for the need of quantification of inflammation in rheumatoid arthritis (RA) [1][2][3][4]. Ultrasonography (US) has proven its superiority over clinical examination in detecting synovial hypertrophy [5][6][7] and power Doppler US (PDUS) is currently used for the semiquanitative grading of intraarticular inflammation.…”

Section: Introductionmentioning

confidence: 99%

The evolution of time-intensity curves of contrast enhanced ultrasonography in early arthritis patients with wrist involvement.

Tămaș

Bondor

Rednic³

et al. 2015

Med Ultrason

View full text Add to dashboard Cite

Aims: The aim of the study was to assess the evolution of time-intensity curves parameters of contrast-enhanced ultrasonography (CEUS) after 6 months of conventional treatment in early arthritis patients with wrist involvement. Material and methods: Patients diagnosed with early rheumatoid arthritis or undifferentiated arthritis on the basis of 2010 ACR/EU-LAR classification criteria, with bilateral wrist arthritis and both radiocarpal (RC) and intercarpal (IC) synovial hypertrophy identified by grey-scale ultrasonography, were enrolled. Synovial hypertrophy was semi-quantitatively scored (grade 0-3) by grey-scale and by Power Doppler at wrist level. CEUS was performed using Sonovue. The region of interest was selected as the area corresponding to the synovial hypertrophy of the RC and IC joints. Time-intensity curves parameters were calculated with Contrast Dynamic Software. The minimum and the maximum values of Peak, area under the curve (AUC), and slope were selected for each patient at baseline and after 6 months of conventional treatment. The difference between the visits was noted as "Δ". Results: Eleven patients fulfilled the inclusion criteria. Maximum time-intensity curves parameters' difference significantly decreased at 6 months: Peak (30.00±5.90% vs 23.22±5.22%, p=0.008), AUC (1206.08±216.91%s vs 949.13±280.12%s, p=0.04) and slope (1.6 (1.4;2.3) %/s vs 1(0.7;1.2) %/s, p=0.03). Moderate correlations were found between maximum ΔPeak, maximum ΔAUC and maximum ΔPower Doppler grade (r=0.44, p=0.17; r=0.46, p=0.16, respectively). Conclusions: Peak and AUC for joints that had high baseline values significantly decreased following treatment with conventional synthetic drugs in EA patients with wrist arthritis. This decrease in Peak and AUC was moderately correlated with a decrease in US parameters. The joint with the highest values of these parameters may be used for evaluation of EA patients at follow-up.

show abstract

MRI quantification of rheumatoid arthritis: Current knowledge and future perspectives

Cited by 58 publications

References 66 publications

Accurate quantitative assessment of synovitis in rheumatoid arthritis using pixel-by-pixel, time–intensity curve shape analysis

Accurate quantitative assessment of synovitis in rheumatoid arthritis using pixel-by-pixel, time–intensity curve shape analysis

Evaluating automated dynamic contrast enhanced wrist 3T MRI in healthy volunteers: One-year longitudinal observational study

The evolution of time-intensity curves of contrast enhanced ultrasonography in early arthritis patients with wrist involvement.

Contact Info

Product

Resources

About