MRI periventricular lesions in adults

Gerard, Gary F.; Weisberg, Leon A.

doi:10.1212/wnl.36.7.998

Cited by 260 publications

(78 citation statements)

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“…This does not mean, however, that the grey matter structures are affected with no consequence to their associated fiber tracts, but only that such consequences may be manifested as signal changes w.%hin the white matter rather than shrinkage. These observed signal changes in the white matter agree with earlier reports of an increasing incidence of visually identified high signal areas in the elderly (Gerard and Weisberg 1986;Awad et al 1986aAwad et al , 1986bAwad et al , 1987Fazekas et al 1987;Kertesz et al 1988). The age function reported here for the index of white matter abnormality is quite similar to that obtained with our measure of subcortical hyperintensities (Jemigan et al 1990).…”

Section: Discussionsupporting

confidence: 91%

“…Q signal hyperintensities within the white matter were also app These measures revealed significant increases in these abnorma a finding noted in qualitative evaluations of normal elderly subjects by several investigators (Gerard and Weisberg 1986;Awad et al 1986aAwad et al , 1986bFazekas et al 1987;Kertesz et al 1988). The present study further describes the age-related changes in brain structure, focusing on specific cerebral grey matter structures, both cortical and subcortical, in adults between 30 and 79 years of age.…”

Section: Ictroductionsupporting

confidence: 75%

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Cerebral structure on MRI, Part I: Localization of age-related changes

Jernigan

Archibald

Berhow

et al. 1991

Biological Psychiatry

356

179

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Section: Discussionsupporting

confidence: 91%

Section: Ictroductionsupporting

confidence: 75%

Cerebral structure on MRI, Part I: Localization of age-related changes

Jernigan

Archibald

Berhow

et al. 1991

Biological Psychiatry

356

179

View full text Add to dashboard Cite

“…The same lesion was often observed in the clinically healthy aged human brain. Gerard and Weisherg [19] reported that 7.8% of human over age 50 years showed perivascular hyper-intensity area on T2-weighted images without symptoms of cerebrovascular disease. The area was resulted from the changes of myelin structure with fluid-filled space in white matter [19,29].…”

Section: Discussionmentioning

confidence: 99%

“…Gerard and Weisherg [19] reported that 7.8% of human over age 50 years showed perivascular hyper-intensity area on T2-weighted images without symptoms of cerebrovascular disease. The area was resulted from the changes of myelin structure with fluid-filled space in white matter [19,29]. Since the degeneration of white mater was reported in dogs aged more than 14-year-old [18], the hyper-intensity area on T2-weigted images was considered to be one of the ageassociated changes in white matter in the dog brain, although the area observed in beagle dogs was slightly mild compared with that in the human.…”

Section: Discussionmentioning

confidence: 99%

Changes of Magnetic Resonance Imaging on the Brain in Beagle Dogs with Aging

Kimotsuki

Nagaoka

Yasuda

et al. 2005

The Journal of Veterinary Medical Science

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ABSTRACT. Age-associated changes of magnetic resonance imaging (MRI) on the brain were evaluated in 19 beagle dogs aged from 8-month-to 16-year-old. A significant correlation of the volume of lateral ventricle space was observed in the dogs with age advanced, however, no correlation was found between hippocampus size and the aging. The hypo-intensity areas on T2-weighted MRI were detected in globus pallidus and substantia nigra with a significant correlation of both intensity ratios to lateral ventricle with age advanced. These areas were coincided with the accumulation of iron in the slice of the brain with Perls' staining. In addition, hyperintensity area, suggesting perivascular demyelination with fluid-filled space, was also observed in white matter surrounding the lateral ventricle on T2-weighted MRI. These results suggested that age-associated changes of T2-weighted MRI were developed in the dog brain, especially in globus pallidus, substantia nigra, and white matter surrounding lateral ventricle, like as those reported in the human brain KEY WORDS: age-associated change, brain, canine, hypo-and hyper-intensity, MRI.J. Vet. Med. Sci. 67(10): 961-967, 2005 Magnetic resonance imaging (MRI) has been used as a noninvasive and useful diagnostic technique for evaluating age related brain disorders, such as Alzheimer's disease, Parkinson's disease, and dementia, indicating severe atrophy of the brain, hippocampus, amygdala, and temporal lobe, gray matter, and dilatation of ventricle space, and cortical sulci, [9,17,26,28,34]. However, age-associated similar changes of MRI was also observed in the clinically healthy human brain, indicating brain atrophy, dilatation of ventricle space and cortical sulci, hypo-intensity area in globus pallidus and substantia nigra, and hyper-intensity area in white matter [7,16,20,31]. In addition, age-associated pathological changes of the brain, including developments of senile plaque, decrease number of neuronal cell, deposit of lipofuscin, and activation of astrocyte, have also been well documented [8,12,23,38]. Therefore, it is necessary for diagnose of age related degenerative diseases to evaluate age-associated changes in the brain. Various age-associated changes were detected in aged dogs with occasionally abnormal behaviors [4,6,10,27,30], like as those reported in human [13]. Although MRI has been applied in veterinary clinics and experimental medicine, several reports were on clinical cases and few reports on age-associated changes in the dog brain [5,37]. This study deals with ageassociated changes in MRI on the brain, especially lateral ventricle space, hippocampus size, and hypo-and hyperintensity area, in beagle dogs with age advanced. MATERIALS AND METHODS Animals:Clinically healthy 19 beagle dogs (8 male and 11 female), aged from 8-month-to 16-year-old, were used. All the dogs were bred, reared, and kept in Medicinal Safety Research Laboratories, Sankyo Co., Ltd. under the condition of circumstance temperature at 22 ± 2°C. The air extraction was designed to be 10...

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“…Although studies of AD with MR have emphasized the prevalence and appearance of high signal abnormalities in cortical and subcortical ;auc- (Johnson et al 1987;Fazekas et al 1987), the high incidence of these abnormalities i~: nonsymptomatic elderly controls (Fazekas et al 1987;Gerard and Weisberg 1986;Awad et al 1986aAwad et al , 1986bAwad et al , 1987Kertesz et al 1988) complicates the interpretation of such changes in AD. Attempts to differentiate AD patients from controls and other patients using MR signal values within tissue, such as Tt and proton density values, have met wtth mixed success (Besson et al 1983(Besson et al , 1985Christie et al 1988).…”

Section: Introductionmentioning

confidence: 99%