MRI of the marrow in the paediatric skeleton

Foster, K; Chapman, Stephen; Johnson, Karen A.

doi:10.1016/j.crad.2004.02.001

Cited by 60 publications

(33 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several papers [5,6,19,20] describe the normal marrow variations that occur in the growing child. The skeleton develops with enchondral growth, ossification and conversion of haematopoietic (red) marrow into fatty (yellow) marrow.…”

Section: Discussionmentioning

confidence: 99%

“…The lack of similar studies in children with JIA may reflect difficulties in fully understanding the signal intensity returned from developing bone marrow. The growth and maturation of carpal bones mirror that of the epiphysis of tubular bones [5], with marrow conversion from haematopoietic to fatty marrow being complete approximately 6 months after the appearance of the ossific nucleus [6]. This means that most of the carpals contain fatty marrow at the age of 5-6 years, and that MRI appearances must be interpreted accordingly.…”

Section: Introductionmentioning

confidence: 96%

See 1 more Smart Citation

MRI assessment of bone marrow in children with juvenile idiopathic arthritis: intra- and inter-observer variability

et al. 2012

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

MRI assessment of bone marrow in children with juvenile idiopathic arthritis: intra- and inter-observer variability

et al. 2012

View full text Add to dashboard Cite

show abstract

“…The distribution of haematopoietic marrow and its cellular content vary with age [1] : haematopoietic marrow decreases and fatty marrow increases conversely. This physiological phenomenon is called conversion.…”

Section: Normal Bone Marrowmentioning

confidence: 99%

Improving the interpretation of bone marrow imaging in cancer patients

et al. 2006

View full text Add to dashboard Cite

Magnetic resonance imaging (MRI) is the best technique for bone marrow imaging. The MRI signal of bone marrow depends on the quantity of fat it contains and on its cellularity. Evaluation of marrow of patients treated for cancer is complicated by age and osseous site related changes in the distribution of normal haematopoietic (red) and fatty (yellow) marrow and by the changes induced by treatments: decrease in pathological cellularity, increase in fat proportion, conversion of red marrow to fatty marrow or, conversely, reconversion of fatty marrow in normal haematopoietic red marrow. The treatments used in oncology modify pathological marrow but also normal marrow and may sometimes lead to complications. These modifications may be focal or diffuse, homogeneous or patchy and symmetrical or asymmetric. The knowledge of bone marrow physiological status and post-therapeutic patterns is important for the interpretation of marrow disorders and effects of therapy and to avoid false-positive diagnosis of marrow metastases and tumour progression. The aim of this paper is to recall the MRI patterns of normal bone marrow and normal variations and to show the effects of treatments on bone tissue and normal bone marrow and treatment-related modifications on pathological marrow.

show abstract

“…Conventional spin echo (SE) T1-weighted sequence is effective for imaging bone marrow due to its capability in showing the different signal intensity of red and yellow marrow, to the relatively high sensitivity in detecting bone marrow pathology and to good image quality and relatively short imaging time [4][5][6][7][8][9][10][11]. Limitations of SE T1-weighted sequence include low specificity, as most bone marrow disorders exhibit low signal intensity, and relatively low sensitivity in detecting pathology in children due to the similarity of signal intensity characteristics of normal red marrow with the predominant low signal of bone marrow disorders with this sequence [12][13][14].…”

Section: Imaging Techniquesmentioning

confidence: 99%

“…La sequenza spin echo (SE) convenzionale T1-pesata è una sequenza efficace per lo studio del midollo osseo, grazie alla capacità di evidenziare la differente intensità di segnale del midollo rosso e giallo, alla capacità sufficientemente elevata di individuare la patologia del midollo osseo, alla buona qualità di immagine e al tempo di acquisizione relativamente breve [4][5][6][7][8][9][10][11]. Gli svantaggi della sequenza SE T1-pesata comprendono la bassa specificità, dal momento che la maggior parte delle malattie del midollo osseo ha bassa intensità di segnale, e la sensibilità relativamente bassa in età pediatrica, a causa della somiglianza di intensità di segnale fra il midollo rosso normale e il basso segnale delle patologie midollari in questa sequenza [12][13][14].…”

Section: Tecniche DI Imagingunclassified

The evolving role of MRI in oncohaematological disorders

et al. 2007

View full text Add to dashboard Cite

Magnetic resonance imaging (MRI) has opened new possibilities to current diagnostic radiology in the evaluation of bone marrow. Compared with other imaging modalities, MRI is the only technique able to directly visualise bone marrow with its different components of red and yellow marrow. Other advantages of MRI are high-contrast resolution and multiplanar view, as well as extensive coverage of the skeleton with whole-body MRI (WBMRI). However, specificity of signal alterations of bone marrow is low. Therefore, MRI findings need to be integrated with clinical and laboratory findings as well as with haematological and oncological evaluation. MRI provides information that effectively aids diagnosis, staging and follow-up of various bone marrow disorders. There is increasing interest in the capabilities of MRI in the evaluation of bone marrow, in particular of haematological malignancies. According to some authors much work remains to be done to improve sensitivity and specificity of MRI in order to define the real clinical value of this imaging modality in the multidisciplinary management of patients with a haematological malignancy. This article presents recent developments and perspectives in the use of MRI in oncohaematological diseases.

show abstract

MRI of the marrow in the paediatric skeleton

Cited by 60 publications

References 60 publications

MRI assessment of bone marrow in children with juvenile idiopathic arthritis: intra- and inter-observer variability

MRI assessment of bone marrow in children with juvenile idiopathic arthritis: intra- and inter-observer variability

Improving the interpretation of bone marrow imaging in cancer patients

The evolving role of MRI in oncohaematological disorders

Contact Info

Product

Resources

About