MRI of the lung gas-space at very low-field using hyperpolarized noble gases

Venkatesh, Arvind K.; Zhang, Adelaide X; Mansour, Joey; Kubatina, Lyubov V.; Oh, Chang Hyun; Blasche, G.; Ünlü, M. S.; Balamore, Dilip; Jólesz, Ferenc A.; Goldberg, Bennett B.; Albert, Mitchell S.

doi:10.1016/s0730-725x(03)00178-4

Cited by 37 publications

(43 citation statements)

References 21 publications

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“…This prevented us from using a slice selection gradient to obtain finer details of lung structure and resulted in fullprojection images with SNR ~10. However, this does not reflect an inability of very-low-field MRI to yield clinical-quality images of inhaled 3 He in the human lung, but rather highlights the engineering challenges that remain in custom-designing very-low-field MRI scanners that operate well below the frequency range of traditional clinical MRI scanners (22,23,25).…”

Section: Discussionmentioning

confidence: 99%

“…We measured a 3 He of >100 ms at 2 mT in excised rat lungs, as opposed to ~5 ms at 1.5 T (19). More recently, several groups have performed in vivo human lung 3 He MRI at fields of 0.15 T (20), 0.1 T (21), 15 mT (22), and 3 mT (23,24) using clinical scanners with resistive (21,23), permanent (20), or ramped-down superconducting (22) magnets. One study has been performed with a subject standing in a resistive magnet system operating at 3 mT (24).…”

Section: Introductionmentioning

confidence: 99%

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A system for open‐access ³He human lung imaging at very low field

Ruset¹,

Tsai²,

Mair³

et al. 2006

Concepts Magn Reson

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We describe a prototype system built to allow open-access very-low-field MRI of human lungs using laser-polarized 3 He gas. The system employs an open four-coil electromagnet with an operational B 0 field of 4 mT, and planar gradient coils that generate gradient fields up to 0.18 G/cm in the x and y direction and 0.41 G/cm in the z direction. This system was used to obtain 1 H and 3 He phantom images and supine and upright 3 He images of human lungs. We include discussion on challenges unique to imaging at 50 -200 kHz, including noise filtering and compensation for narrow-bandwidth coils.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A system for open‐access ³He human lung imaging at very low field

Ruset¹,

Tsai²,

Mair³

et al. 2006

Concepts Magn Reson

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show abstract

“…(Additional demonstrations of HG imaging have recently been reported at 15 mT [14]). The goal of our research here was to begin this exploration, first, by developing appropriate apparatus, and second, by performing in-vitro and in-vivo CPMG measurements [15] using hyperpolarized 3 He.…”

Section: Introductionmentioning

confidence: 96%

In vivo NMR of hyperpolarized 3He in the human lung at very low magnetic fields

Bidinosti¹,

Choukeife²,

Nacher³

et al. 2003

Journal of Magnetic Resonance

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We present NMR measurements of the diffusion of hyperpolarized 3 He in the human lung performed at fields much lower than those of conventional MRI scanners. The measurements were made on standing subjects using homebuilt apparatus operating at 3 mT. O 2 -limited transverse relaxation (T 2 up to 15-35 s) could be measured invivo. Accurate global diffusion measurements have been performed in-vivo and in a plastic bag; the average apparent diffusion coefficient (ADC) in-vivo was 14.2 ± 0.6 mm 2 /s, whereas the diffusion coefficient in the bag ( 3 He diluted in N 2 ) was 79.5 ± 1 mm 2 /s. 1D ADC mapping with high SNR (∼ 200 -300) demonstrates the real possibility of performing quality lung imaging at extremely low fields.

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“…These results are a significant improvement over images obtained previously at 3.9 mT using our prototype open-access imager [43,42], and by others at B 0 < 0.1 T [46,48]. In future work, we plan to implement slice selection, which will improve the visual quality of 2D anatomical images.…”

Section: Discussionmentioning

confidence: 53%

“…This system achieved ~ 4 mm image resolution and benefited from the reduction of susceptibility-induced gradients in rat lungs, where a 3 He of ~ 100 ms was measured, which compared favorably to that measured at 1.5 T (~ 5 ms) [39]. More recently, several groups have performed in vivo human lung 3 He MRI at fields of 0.15 T [44], 0.1 T [45], 15 mT [46], and 3 mT [47,48] using clinical scanners with resistive [45,48], permanent [44] or rampeddown superconducting [46] magnets. One study has been performed with a subject standing in a resistive magnet system operating at 3 mT [47].…”

Section: Introductionmentioning

confidence: 99%

An open-access, very-low-field MRI system for posture-dependent 3He human lung imaging

Tsai

Mair

Rosen

et al. 2008

Journal of Magnetic Resonance

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We describe the design and operation of an open-access, very-low-field, magnetic resonance imaging (MRI) system for in-vivo hyperpolarized 3 He imaging of the human lungs. This system permits the study of lung function in both horizontal and upright postures, a capability with important implications in pulmonary physiology and clinical medicine, including asthma and obesity. The imager uses a bi-planar B 0 coil design that produces an optimized 65 G (6.5 mT) magnetic field for 3 He MRI at 210 kHz. Three sets of bi-planar coils produce the x, y, and z magnetic field gradients while providing a 79-cm inter-coil gap for the imaging subject. We use solenoidal Q-spoiled RF coils for operation at low frequencies, and are able to exploit insignificant sample loading to allow for pretuning/matching schemes and for accurate pre-calibration of flip angles. We obtain sufficient SNR to acquire 2D 3 He images with up to 2.8 mm resolution, and present initial 2D and 3D 3 He images of human lungs in both supine and upright orientations. 1 H MRI can also be performed for diagnostic and calibration reasons.

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MRI of the lung gas-space at very low-field using hyperpolarized noble gases

Cited by 37 publications

References 21 publications

A system for open‐access ³He human lung imaging at very low field

A system for open‐access ³He human lung imaging at very low field

In vivo NMR of hyperpolarized 3He in the human lung at very low magnetic fields

An open-access, very-low-field MRI system for posture-dependent 3He human lung imaging

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MRI of the lung gas-space at very low-field using hyperpolarized noble gases

Cited by 37 publications

References 21 publications

A system for open‐access 3He human lung imaging at very low field

A system for open‐access 3He human lung imaging at very low field

In vivo NMR of hyperpolarized 3He in the human lung at very low magnetic fields

An open-access, very-low-field MRI system for posture-dependent 3He human lung imaging

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A system for open‐access ³He human lung imaging at very low field

A system for open‐access ³He human lung imaging at very low field