MRI of the lumbar intervertebral disc

Morgan, S.; Saifuddin, Asif

doi:10.1016/s0009-9260(99)91173-x

Cited by 28 publications

(15 citation statements)

References 67 publications

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“…Previous studies have implicated DDD with low back pain [9][10][11]. During the intial PG degradation, the PGs of NP breakdown to clusters of short aggregated and non-aggregated molecules, the GAG content decreases, and the NP's capacity to bind water reduces [12,13]. The increased modulus and decreased hydrostatic pressure triggers the NP to undergo a phase change, from a fluid-like material to a more solid-like material [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Advances in Magnetic Resonance Imaging for the Assessment of Degenerative Disc Disease of the Lumbar Spine

Wang

Auerbach

Witschey

et al. 2007

Seminars in Spine Surgery

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The intervertebral disc is characterized by a tension-resisting annulus fibrosus, and a compressionresisting nucleus pulposus composed largely of proteoglycan. Both the annulus and the nucleus function in concert to provide the disc with mechanical stability. Early disc degeneration begins in the nucleus with proteoglycan depletion. Quantitative MRI techniques have been developed to noninvasively quantify the earliest degenerative changes that occur within the disc. Our ability to identify and quantify these early biochemical changes will provide a better understanding of the pathophysiology of disc degeneration and facilitate the study of interventions that aim to halt or reverse the degenerative process.

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Section: Introductionmentioning

confidence: 99%

Advances in Magnetic Resonance Imaging for the Assessment of Degenerative Disc Disease of the Lumbar Spine

Wang

Auerbach

Witschey

et al. 2007

Seminars in Spine Surgery

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“…Conventional magnetic resonance imaging techniques are not sensitive enough to detect early stages of disc degeneration 8 . Other techniques, including delayed gadoliniumenhanced and sodium magnetic resonance imaging, may have sufficient sensitivity but there are also substantial limitations with regard to implementation of these methods [9][10][11] .…”

mentioning

confidence: 99%

Noninvasive Quantification of Human Nucleus Pulposus Pressure with Use of T1ρ-Weighted Magnetic Resonance Imaging

Nguyẽ̂n

Johannessen

Yoder

et al. 2008

The Journal of Bone and Joint Surgery-American Volume

103

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“…Conventional magnetic resonance imaging (MRI) techniques provide excellent detection of late-stage degenerative changes [14], but not of early degenerative changes in the matrix of IVD [15]. Delayed gadolinium enhanced MRI (dGemric) and Na-MRI have been used to quantify PG in articular cartilage [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

A needle micro-osmometer for determination of glycosaminoglycan concentration in excised nucleus pulposus tissue

et al. 2013

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Purpose Aggrecan is one of the major macromolecular components of the intervertebral disc (IVD) and its loss is an early sign of degeneration. Restoration of aggrecan, and hence of biomechanical properties, is a major objective of biological therapies. At present, assessment of aggrecan concentration via its glycosaminoglycan (GAG) content is accomplished using biochemical and histological methods which require sacrifice of tissue. A minimally invasive method for assessing GAG, and hence aggrecan, which can avoid destruction of tissue, would be of benefit. Methods We have developed a needle micro-osmometer that is capable of measuring flux of saline into excised human nucleus pulposus (NP) tissue. Using the isotropic osmotic stress technique to assess the swelling pressure of the excised NP tissue and assuming negligible collagen tensile stress, we were able to relate the flux to the tissue fixed charge density (FCD). GAG concentration is evaluated from its FCD via the radioactive tracer technique.Samples representing different ages (28-59 years) and degeneration grades (1-4) were analyzed. Results The flux is controlled by both the osmotic pressure difference across the probe's semi-permeable membrane and by the tissue permeability. A linear correlation was found between flux and the tissue FCD. The equation describing the linear fit is FCD/(total tissue hydration) = 1.97 9

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MRI of the lumbar intervertebral disc

Cited by 28 publications

References 67 publications

Advances in Magnetic Resonance Imaging for the Assessment of Degenerative Disc Disease of the Lumbar Spine

Advances in Magnetic Resonance Imaging for the Assessment of Degenerative Disc Disease of the Lumbar Spine

Noninvasive Quantification of Human Nucleus Pulposus Pressure with Use of T1ρ-Weighted Magnetic Resonance Imaging

A needle micro-osmometer for determination of glycosaminoglycan concentration in excised nucleus pulposus tissue

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