MRI of Pulmonary Nodules

Kurihara, Yasuyuki; Matsuoka, Shin; Yamashiro, Tsuneo; Fujikawa, Atsuko; Matsushita, Shoichiro; Yagihashi, Kunihiro; Nakajima, Yasuo

doi:10.2214/ajr.13.11618

Cited by 50 publications

(34 citation statements)

References 65 publications

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“…Previous investigators’ findings are in accordance with our results [54, 55]. Future technical improvements may overcome this limitation [56, 57]. …”

Section: Discussionsupporting

confidence: 93%

Speeding up PET/MR for cancer staging of children and young adults

et al. 2016

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Objective Combining 18F-FDG PET with whole-body MR for paediatric cancer staging is practically feasible if imaging protocols can be streamlined. We compared 18F-FDG PET/STIR with accelerated 18F-FDG PET/FSPGR for whole-body tumour imaging in children and young adults. Methods Thirty-three children and young adults (17.5±5.5 years, range 10–30 years) with malignant lymphoma or sarcoma underwent a 18F-FDG PET staging exam, followed by ferumoxytol-enhanced STIR and FSPGR whole-body MR. 18F-FDG PET scans were fused with MR data and the number and location of tumours on each integrated exam was determined. Histopathology and follow-up imaging served as standard of reference. The agreement of each MR sequence with the reference and the whole-body imaging times were compared using Cohen’s kappa coefficient and student t-test, respectively. Results Comparing 18F-FDG PET/FSPGR to 18F-FDG PET/STIR, sensitivities were 99.3% for both, specificities were statistically equivalent, 99.8% versus 99.9% and the agreement with the reference based on Cohen’s kappa coefficient was also statistically equivalent, 0.989 versus 0.992. However, the total scan-time for accelerated FSPGR of 19.8±5.3 minutes was significantly shorter compared to 29.0±7.6 minutes for STIR (p=0.001). Conclusion 18F-FDG PET/FSPGR demonstrated equivalent sensitivities and specificities for cancer staging compared to 18F-FDG PET/STIR, but could be acquired with shorter acquisition time.

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“…Previous investigators’ findings are in accordance with our results [54, 55]. Future technical improvements may overcome this limitation [56, 57]. …”

Section: Discussionsupporting

confidence: 93%

Speeding up PET/MR for cancer staging of children and young adults

et al. 2016

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“…Moreover, the costs, the limited availability, the extensive patient cooperation required and the lower familiarity of the clinicians are also problematic. Additionally, MRI is unsuitable for the study of small thoracic lesions because of the low signal-to-noise ratio in the lung, motion artifacts due to cardiac and respiratory activity and the lower spatial resolution as compared to CT [64]. …”

Section: Technique Limitationsmentioning

confidence: 99%

The Status of Neuroendocrine Tumor Imaging: From Darkness to Light?

et al. 2014

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Diagnostic imaging plays a pivotal role in the diagnosis, staging, treatment selection and follow-up for neuroendocrine tumors. The available diagnostic strategies are morphologic imaging, including computed tomography, magnetic resonance imaging (MRI) and ultrasound techniques, and molecular imaging, including scintigraphy with ¹¹¹In-pentetreotide and positron emission tomography with ⁶⁸Ga-DOTA-peptides, ¹⁸F-DOPA and ¹¹C-5-HTP. A combination of anatomic and functional techniques is routinely performed to optimize sensitivity and specificity. The introduction of diffusion-weighted MRI and dynamic contrast-enhanced techniques represents a promising advance in radiologic imaging, whereas new receptor-binding peptides, including somatostatin agonists and antagonists, represent the recent most favorable innovation in molecular imaging. Future development includes the short-term validation of these techniques, but in extension also a more comprehensive multilevel integration of biologic information pertaining to a specific tumor and patient, possibly encompassing genomic considerations, currently evolving as a new entity denoted ‘precision medicine'. The ideal is a diagnostic sequence that captures the global status of an individual's tumor and encompasses a multidimensional characterization of tumor location, metabolic performance and target identification. To date, advances in imagery have focused on increasing resolution, discrimination and functional characterization. In the future, the fusion of imagery with the parallel analysis of biological and genomic information has the potential to considerably amplify diagnosis.

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“…International CPS and specific pediatric tumor registries, such as exists for childhood gastrointestinal stromal tumors (GIST), will help provide data that will undoubtedly lead to protocol optimization and rationalization of those CPS in which WBMRI is shown to be most effective (38,40). Further WBMRI protocol modifications will arise from advances in MRI, such as techniques for screening for lung metastases (41).…”

Section: Who Should Do It?mentioning

confidence: 99%

Pediatric Cancer Predisposition Imaging: Focus on Whole-Body MRI

Greer

Voss

States

2017

Clinical Cancer Research

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The American Association for Cancer Research convened a meeting of international pediatric oncologists, geneticists, genetic counselors, and radiologists expert in childhood cancer predisposition syndromes (CPS) in October 2016 to propose consensus surveillance guidelines. Imaging plays a central role in surveillance for most, though not all, syndromes discussed. While encompassing the full gamut of modalities, there is increasing emphasis on use of nonionizing radiation imaging options such as magnetic resonance imaging (MRI) in children and adolescents, especially in the pediatric CPS population. In view of rapid evolution and widespread adoption of whole-body MRI (WBMRI), the purpose of our review is to address WBMRI in detail. We discuss its place in the surveillance of a range of pediatric CPS, the technical and logistical aspects of acquiring and interpreting these studies, and the inherent limitations of WBMRI. We also address issues associated with sedation and use of gadolinium-based contrast agents in MRI in children.

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MRI of Pulmonary Nodules

Abstract: Although clinical applications of pulmonary MRI face technical limitations, currently available MRI methods have contributed to morphologic and functional evaluations of pulmonary nodules.

Cited by 50 publications

References 65 publications

Speeding up PET/MR for cancer staging of children and young adults

Speeding up PET/MR for cancer staging of children and young adults

The Status of Neuroendocrine Tumor Imaging: From Darkness to Light?

Pediatric Cancer Predisposition Imaging: Focus on Whole-Body MRI

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