MRI of lungs using partial liquid ventilation with water‐in‐perfluorocarbon emulsions

Huang, Menggui; Ye, Qing; Williams, Donald S.; Ho, Chien

doi:10.1002/mrm.10231

Cited by 26 publications

(9 citation statements)

References 26 publications

(46 reference statements)

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“…By contrast 1 H MRI is handicapped by lack of water signal. In a novel approach, Huang, et al [266] applied 1 H MRI to the water in a perfluorocarbon emulsion and found considerably enhanced structural information. Liquid and aerosol ventilation can be stressful, whereas inhalation of inert gas, may be more practical, as shown by proof of principal 15 using CF 4 or C 2 F 6.…”

Section: Lung Volumementioning

confidence: 98%

19F: A Versatile Reporter for Non-Invasive Physiology and Pharmacology Using Magnetic Resonance

Jian¹,

Kodibagkar²,

Cui³

et al. 2005

CMC

229

185

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The fluorine atom provides an exciting tool for diverse spectroscopic and imaging applications using Magnetic Resonance. The organic chemistry of fluorine is widely established and it can provide a stable moiety for interrogating many aspects of physiology and pharmacology in vivo. Strong NMR signal, minimal background signal and exquisite sensitivity to changes in the microenvironment have been exploited to design and apply diverse reporter molecules. Classes of agents are presented to investigate gene activity, pH, metal ion concentrations (e.g., Ca(2+), Mg(2+), Na(+)), oxygen tension, hypoxia, vascular flow and vascular volume. In addition to interrogating speciality reporter molecules, (19)F NMR may be used to trace the fate of fluorinated drugs, such as chemotherapeutics (e.g., 5-fluorouracil, gemcitabine), anesthetics (e.g., isoflurane, methoxyflurane) and neuroleptics. NMR can provide useful information through multiple parameters, including chemical shift, scalar coupling, chemical exchange and relaxation processes (R1 and R2). Indeed, the large chemical shift range (approximately 300 ppm) can allow multiple agents to be examined, simultaneously, using NMR spectroscopy or chemical shift selective imaging.

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Section: Lung Volumementioning

confidence: 98%

19F: A Versatile Reporter for Non-Invasive Physiology and Pharmacology Using Magnetic Resonance

Jian¹,

Kodibagkar²,

Cui³

et al. 2005

CMC

229

185

View full text Add to dashboard Cite

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“…However, 19 F MRI has been used for a variety of research applications including studying tumor metabolism (17–19), mapping physiologic pO 2 in various tissues (20–23), quantifying albumin concentration (24), and mapping liquid ventilation (25, 26). To overcome the limited abundance of fluorine‐containing compounds in vivo, many of these studies were performed at high magnetic fields, 4.7 T or greater (21–23, 25, 27), and/or they increased the concentration of 19 F via direct injection or physiologic replacement (21, 25, 26). For targeted perfluorocarbon nanoparticles, the binding of the agent to the tissue or epitope of interest serves to increase the concentration of fluorine in that area to a level that allows 19 F spectroscopy and imaging within a reasonable scan time.…”

mentioning

confidence: 99%

Quantitative “magnetic resonance immunohistochemistry” with ligand‐targeted ¹⁹F nanoparticles

Morawski

Winter

et al. 2004

Magnetic Resonance in Med

190

175

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Unstable atherosclerotic plaques exhibit microdeposits of fibrin that may indicate the potential for a future rupture. However, current methods for evaluating the stage of an atherosclerotic lesion only involve characterizing the level of vessel stenosis, without delineating which lesions are beginning to rupture. Previous work has shown that fibrin-targeted, liquid perfluorocarbon nanoparticles, which carry a high payload of gadolinium, have a high sensitivity and specificity for detecting fibrin with clinical 1 H MRI. In this work, the perfluorocarbon content of the targeted nanoparticles is exploited for the purposes of 19 F imaging and spectroscopy to demonstrate a method for quantifiable molecular imaging of fibrin in vitro at 4.7 T. Additionally, the quantity of bound nanoparticles formulated with different perfluorocarbon species was calculated using spectroscopy. Results indicate that the high degree of nanoparticle binding to fibrin clots and the lack of background 19 F signal allow accurate quantification using spectroscopy at 4.7 T, as corroborated with proton relaxation rate measurements at 1.5 T and trace element (gadolinium) analysis. Finally, the extension of these techniques to a clinically relevant application, the evaluation of the fibrin burden within an ex vivo human carotid endarterectomy sample, demonstrates the potential use of these particles for uniquely identifying unstable atherosclerotic lesions in vivo.

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“…It was also discovered that these compounds exhibited a unique property: their longitudinal relaxation time (R 1 ) varies linearly with the partial pressure of O 2 to which they were exposed (10). This created an impetus for further studies and resulted in a variety of techniques to noninvasively map the oxygen concentration in tumors (12,13,22), heart (23), lungs (24,25), and liver (26). Other studies used perfluorocarbons for general imaging of various organs, including the bowel (11,27).…”

Section: Discussionmentioning

confidence: 97%

Fluorine Cardiovascular Magnetic Resonance Angiography In Vivo at 1.5 T with Perfluorocarbon Nanoparticle Contrast Agents

Neubauer

Caruthers

Hockett

et al. 2007

J. of Cardiovascular Magnetic Resonance

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While the current gold standard for coronary imaging is X-ray angiography, evidence is accumulating that it may not be the most sensitive technique for detecting unstable plaque. Other imaging modalities, such as cardiovascular magnetic resonance (CMR), can be used for plaque characterization, but suffer from long scan and reconstruction times for determining regions of stenosis. We have developed an intravascular fluorinated contrast agent that can be used for angiography with cardiovascular magnetic resosnace at clinical field strengths (1.5 T). This liquid perfluorocarbon nanoparticle contains a high concentration of fluorine atoms that can be used to generate contrast on 19F MR images without any competing background signal from surrounding tissues. By using a perfluorocarbon with 20 equivalent fluorine molecules, custom-built RF coils, a modified clinical scanner, and an efficient steady-state free procession sequence, we demonstrate the use of this agent for angiography of small vessels in vitro, ex vivo, and in vivo. The surprisingly high signal generated with very short scan times and low doses of perfluorocarbon indicates that this technique may be useful in clinical settings when coupled with advanced imaging strategies.

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MRI of lungs using partial liquid ventilation with water‐in‐perfluorocarbon emulsions

Cited by 26 publications

References 26 publications

19F: A Versatile Reporter for Non-Invasive Physiology and Pharmacology Using Magnetic Resonance

19F: A Versatile Reporter for Non-Invasive Physiology and Pharmacology Using Magnetic Resonance

Quantitative “magnetic resonance immunohistochemistry” with ligand‐targeted ¹⁹F nanoparticles

Fluorine Cardiovascular Magnetic Resonance Angiography In Vivo at 1.5 T with Perfluorocarbon Nanoparticle Contrast Agents

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MRI of lungs using partial liquid ventilation with water‐in‐perfluorocarbon emulsions

Cited by 26 publications

References 26 publications

19F: A Versatile Reporter for Non-Invasive Physiology and Pharmacology Using Magnetic Resonance

19F: A Versatile Reporter for Non-Invasive Physiology and Pharmacology Using Magnetic Resonance

Quantitative “magnetic resonance immunohistochemistry” with ligand‐targeted 19F nanoparticles

Fluorine Cardiovascular Magnetic Resonance Angiography In Vivo at 1.5 T with Perfluorocarbon Nanoparticle Contrast Agents

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Quantitative “magnetic resonance immunohistochemistry” with ligand‐targeted ¹⁹F nanoparticles