MRI of diffuse liver disease: characteristics of acute and chronic diseases

Chundru, Surya; Kalb, Bobby; Arif-Tiwari, Hina; Sharma, Puneet; Costello, James; Martín, Diego R.

doi:10.5152/dir.2014.13170

Cited by 32 publications

(19 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Similarly, as seen on day 3, initial resorption of the hematoma temporarily increases fluid content (i.e. edema) which would lead to an increase in the T2 time constant and higher signal intensity (Chundru et al 2014). The remaining hematoma and replacement granulation tissue, as seen on days 7–14, would lead to a residual, localized low signal intensity (Ng et al 2015).…”

Section: Discussionmentioning

confidence: 86%

Non-Invasive Ultrasound Liver Ablation Using Histotripsy: Chronic Study in an In Vivo Rodent Model

Vlaisavljevich

Greve

Cheng

et al. 2016

Ultrasound in Medicine & Biology

View full text Add to dashboard Cite

Hepatocellular carcinoma (HCC) or liver cancer has the fastest growing incidence among cancers in the United States. Current liver ablation methods are thermal-based and share limitations due to the heat sink effect from the blood flow through the highly vascular liver. Recently, our group has investigated histotripsy as a non-invasive liver cancer ablation method. Histotripsy is a non-thermal ultrasonic ablation method that fractionates tissue through the control of acoustic cavitation. Previous experiments in an in vivo porcine model show that histotripsy can create well-confined lesions in the liver through ribcage obstruction without damaging the overlying ribs and other tissues. Histotripsy can also completely fractionate liver tissue surrounding major vessels while preserving the vessels. In this study, we investigate the long-term effects of histotripsy liver ablation in a rodent model. We hypothesize that the fractionated histotripsy lesion will be resorbed by the liver, resulting in effective tissue healing. To test this hypothesis, the livers of 20 healthy rats were treated with histotripsy using an 8-element 1 MHz histotripsy transducer. Rats were euthanized after 0, 3, 7, 14, and 28 days (n=4). In vivo and post mortem results showed histotripsy lesions were successfully generated in all 20 rats through the intact abdomen. MRI demonstrated primarily negative contrast on day 0, positive contrast on day 3, and rapid normalization of signal intensity thereafter (i.e. signal amplitude returned to baseline levels seen in healthy liver tissue). Histologically, lesions were completely fractionated into an acellular homogenate. The lesions had a maximum cross-sectional area of 17.2±1.9 mm2 and sharp boundaries between the lesion and the healthy surrounding tissue after treatment. As the animals recovered after treatment, the histotripsy tissue homogenate was almost completely replaced by regenerated liver parenchyma, resulting in a small fibrous lesion (<1 mm2 maximum cross-section) remaining after 28 days. The results of this study suggest that histotripsy has potential as a non-invasive liver ablation method for effective tissue removal.

show abstract

Section: Discussionmentioning

confidence: 86%

Non-Invasive Ultrasound Liver Ablation Using Histotripsy: Chronic Study in an In Vivo Rodent Model

Vlaisavljevich

Greve

Cheng

et al. 2016

Ultrasound in Medicine & Biology

View full text Add to dashboard Cite

show abstract

“…Both viruses are transmitted primarily by the fecal-oral route and cause acute viral hepatitis. Children with HAV tend to present with nonspecific gastrointestinal symptoms, and jaundice with cholestasis is common (3,4). Acute viral hepatitis in children is one of the most important diseases and a major public health problem in Copyright © 2020, International Journal of Infection.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Sonographic Signs in Children with Acute Hepatitis in Zahedan City, Southeast of Iran

Sistani¹,

Nouri²,

Mashouri³

et al. 2020

Int J Infect

View full text Add to dashboard Cite

Background: Acute viral hepatitis is a common infection in developing countries among children. Different diagnostic methods for acute hepatitis has been introduced. Objectives: In this study, we have determined the prevalence of sonographic signs in children with acute hepatitis. Methods: A total of 383 children with acute hepatitis were studied in Zahedan city, southeast of Iran. The sampling method was by the enumeration of the cases. Patients underwent ultrasonography in which their sonographic signs of acute hepatitis were investigated and analyzed. Results:The mean age of children was 6.1 ± 2.8 years, with 211 (55.1%) males and 172 (44.9%) females. The prevalence of gallbladder wall edema was 20.1% (77 children), periportal lymphadenopathy 15.1% (58 children), hepatomegaly 4.9% (19 children), increased liver echogenicity 53.0% (203 children), decreased liver echogenicity 15.4% (59 children), splenomegaly 1.8% (7 children), and periportal hyperechogenicity 32.4% (124 children). Conclusions:The results indicate that the most common sonographic signs of patients with acute hepatitis were increased liver echogenicity and periportal hyperechogenicity.

show abstract

“…To date it is the most accurate and reliable method of quantifying liver fat, liver fibrosis and liver inflammation with greater sensitivity and specificity compared to other technologies [80]. MRI can be used for longitudinal follow-up of patients and allows differentiation of the varying stages of diseases and lesions within the liver [81].…”

Section: Magnetic Resonance Imaging (Mri)mentioning

confidence: 99%

“…MRI can be used for longitudinal follow-up of patients and allows differentiation of the varying stages of diseases and lesions within the liver [81]. It is used with contrast reagents, such as gadolinium, and is applicable to measure liver fibrosis [80]. Extracellular uptake of gadolinium-based contrast agents (GBCA) in hepatic fibrosis has been shown to correlate with the early histological stage of fibrosis [82].…”

Section: Magnetic Resonance Imaging (Mri)mentioning

confidence: 99%

See 1 more Smart Citation

Novel circulating- and imaging-based biomarkers to enhance the mechanistic understanding of human drug-induced liver injury

Clarke¹,

Brillanf²,

Antoine

2017

J Clin Transl Res

View full text Add to dashboard Cite

MRI of diffuse liver disease: characteristics of acute and chronic diseases

Cited by 32 publications

References 19 publications

Non-Invasive Ultrasound Liver Ablation Using Histotripsy: Chronic Study in an In Vivo Rodent Model

Non-Invasive Ultrasound Liver Ablation Using Histotripsy: Chronic Study in an In Vivo Rodent Model

Prevalence of Sonographic Signs in Children with Acute Hepatitis in Zahedan City, Southeast of Iran

Novel circulating- and imaging-based biomarkers to enhance the mechanistic understanding of human drug-induced liver injury

Contact Info

Product

Resources

About