MRI monitoring of intratumoral drug delivery and prediction of the therapeutic effect with a multifunctional thermosensitive liposome

Tagami, Tatsuaki; Foltz, Warren D.; Ernsting, Mark J.; Lee, Carol; Tannock, Ian F.; May, Jonathan P.; Li, Shyh-Dar

doi:10.1016/j.biomaterials.2011.05.029

Cited by 198 publications

(168 citation statements)

References 45 publications

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“…7) In order to prepare fluorescently-labeled liposomes, 1 mol% of DiI was added. The mean diameters of liposomes were determined by dynamic light scattering with a particle sizer (ZetaSizer Nano-ZS; Malvern Instrument Ltd., Malvern, U.K.).…”

Section: Methodsmentioning

confidence: 99%

Evaluation of Phosphatidylserine-Specific Peptide-Conjugated Liposomes Using a Model System of Malaria-Infected Erythrocytes

Tagami

Yanai

Terada

et al. 2015

Biological & Pharmaceutical Bulletin

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Malaria is one of the most prevalent parasitic diseases and is most widespread in tropical regions. The malarial parasite grows and reproduces in erythrocytes during its life cycle, resulting in programmed erythrocyte death, termed eryptosis. Lipid scrambling, which occurs following the exposure of anionic lipids such as phosphatidylserine (PS) on the outer surface of erythrocytes, is a characteristic physical change that occurs early during eryptosis. Here, we prepared "PS specific peptide (PSP)"-conjugated liposomes (PSP-liposomes) and investigated whether PSP-liposomes hold promise as a novel strategy for actively targeting eryptosis. Eryptosis was induced by exposing red blood cells (RBCs) to ionomycin, a known calcium ionophore. When PSP liposomes were mixed with either RBCs or RBCs undergoing eryptosis (E-RBCs), the amount of PSP-liposome bound to E-RBCs was much higher than the amount bound to RBCs. However, the amount of PSP-liposome bound to E-RBCs was significantly inhibited by the presence of annexin V protein, which binds specifically to PS. These results suggest that PSP-liposomes could be an effective drug nanocarrier for treating E-RBCs and malaria-infected erythrocytes.

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Section: Methodsmentioning

confidence: 99%

Evaluation of Phosphatidylserine-Specific Peptide-Conjugated Liposomes Using a Model System of Malaria-Infected Erythrocytes

Tagami

Yanai

Terada

et al. 2015

Biological & Pharmaceutical Bulletin

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“…It has been demonstrated that potentially quantitative estimation of drug release based on T 1 relaxation time changes is possible if the contrast agent and drug are both encapsulated in a TSL formulation, 55,[87][88][89]97 thus allowing "drug dose painting" 89 or "chemodosimetry". 88 Because the drug itself is not observed by MRI, a correlation between the contrast agent and drug release had to be established.…”

Section: Applicationsmentioning

confidence: 99%

“…99 This strategy allows a higher amount of contrast agent and drug to be encapsulated whilst avoiding osmotic effects. 86 The second strategy is to coencapsulate both drug and contrast agent in the same TSL, [54][55][56][57]82,83,97 which limits the amount of both components in each TSL. Nevertheless, for both strategies, it has to be ensured that the temperature-dependent drug release rate and MRI signal change are correlated.…”

Section: Applicationsmentioning

confidence: 99%

Thermosensitive liposomal drug delivery systems: state of the art review

Kneidl¹,

Peller²,

Winter³

et al. 2014

IJN

145

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Thermosensitive liposomes are a promising tool for external targeting of drugs to solid tumors when used in combination with local hyperthermia or high intensity focused ultrasound. In vivo results have demonstrated strong evidence that external targeting is superior over passive targeting achieved by highly stable long-circulating drug formulations like PEGylated liposomal doxorubicin. Up to March 2014, the Web of Science listed 371 original papers in this field, with 45 in 2013 alone. Several formulations have been developed since 1978, with lysolipid-containing, low temperature-sensitive liposomes currently under clinical investigation. This review summarizes the historical development and effects of particular phospholipids and surfactants on the biophysical properties and in vivo efficacy of thermosensitive liposome formulations. Further, treatment strategies for solid tumors are discussed. Here we focus on temperature-triggered intravascular and interstitial drug release. Drug delivery guided by magnetic resonance imaging further adds the possibility of performing online monitoring of a heating focus to calculate locally released drug concentrations and to externally control drug release by steering the heating volume and power. The combination of external targeting with thermosensitive liposomes and magnetic resonance-guided drug delivery will be the unique characteristic of this nanotechnology approach in medicine.

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“…Besides their use as drug delivery systems, recently, the liposomes were considered in order to develop patient personalized therapies, to learn about genetic makeup of the subject and how the specific tumour is evolving [116][117][118]. By this way prevention, screening and treatment strategies should be more effective and the side effects reduced.…”

Section: Multifunctional Liposomesmentioning

confidence: 99%

Recent advances in the preparation and application of multifunctional iron oxide and liposome-based nanosystems for multimodal diagnosis and therapy

et al. 2016

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Nowadays, thanks to the successful discoveries in the biomedical field achieved in the last two decades, a deeper understanding about the complexity of mechanistic aspects of different pathological processes has been obtained. As a consequence, even the standard therapeutic protocols have undergone a vast redesign. In fact, the awareness about the necessity to progress towards a combined multitherapy in order to potentially increase the final healing chances has become a reality. One of the crucial elements of this novel approach is that large amounts of detailed information are highly needed and in vivo imaging techniques represent one of the most powerful tools to visualize and monitor the pathological state of the patient. To this scope, due to their unique features, nanostructured materials have emerged as attractive elements for the development of multifunctional tools for diagnosis and therapy. Hence, in this review, the most recent and relevant advances achieved by applying multifunctional nanostructures in multimodal theranosis of different diseases will be discussed. In more detail, the preparation and application of single multifunctional nano-radiotracers based on iron oxides and enabling PET/MRI dual imaging will be firstly detailed. After that, especially considering their highly promising clinical potential, the preparation and application of multifunctional liposomes useful for multimodal imaging and therapy will be reviewed. In both cases, a special focus will be set on the application of such a multifunctional nanocarriers in cancer as well as cardiovascular diseases.

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MRI monitoring of intratumoral drug delivery and prediction of the therapeutic effect with a multifunctional thermosensitive liposome

Cited by 198 publications

References 45 publications

Evaluation of Phosphatidylserine-Specific Peptide-Conjugated Liposomes Using a Model System of Malaria-Infected Erythrocytes

Evaluation of Phosphatidylserine-Specific Peptide-Conjugated Liposomes Using a Model System of Malaria-Infected Erythrocytes

Thermosensitive liposomal drug delivery systems: state of the art review

Recent advances in the preparation and application of multifunctional iron oxide and liposome-based nanosystems for multimodal diagnosis and therapy

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