MRI in the detection of malignant infiltration of bone marrow

Daffner, RH; Lupetin, Anthony R.; Dash, Nilima; Deeb, Ziad L.; Sefczek, RJ; Schapiro, Rolf L.

doi:10.2214/ajr.146.2.353

Cited by 315 publications

(109 citation statements)

References 13 publications

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“…Similar observations have been reported in healthy blood stem cell donors after application of hematopoietic growth factors (4,8). The underlying process of a relative increase of the water fraction in relation to the fatty component is similar for hematological diseases and stimulated hematopoiesis (1,4). Opposedphase gradient-echo (GE) sequences are sensitive to changes of the fat-to-water ratio (9) and are therefore especially suitable for imaging bone marrow (10).…”

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confidence: 63%

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Characterization of hematopoietic bone marrow in male professional cyclists by magnetic resonance imaging of the lumbar spine

Altehoefer

Schmid

Büchert

et al. 2002

Magnetic Resonance Imaging

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Purpose: To prospectively evaluate hematopoietic bone marrow of male professional cyclists in relation to performance data and laboratory data, and in comparison to age-matched healthy volunteers. Materials and Methods:Twenty male cyclists and 44 volunteers (27 males and 17 females) were prospectively studied by magnetic resonance imaging (MRI) at high-field strength. A sagittal T1-weighted (T1-w) spin-echo (SE) sequence, a gradient-echo (GE) sequence with an echo time (TE) for out-of-phase (OOP) imaging, and a turbo inversionrecovery sequence with short inversion time (TIRM) for fat suppression was used. The averaged bone marrow signal intensity (SI) of three adjacent vertebrae was related to the signal of an adjacent nondegenerative disk. Results:The cyclists revealed a significantly different SI as compared to male volunteers in the OOP (0.34 Ϯ 0.14 vs. 0.28 Ϯ 0.09, P Ͻ 0.05) and T1-w sequences (1.62 Ϯ 0.19 vs. 1.77 Ϯ 0.30, P Ͻ 0.05). Only in TIRM was there a significant difference compared to female volunteers (0.36 Ϯ 0.08 vs. 0.44 Ϯ 0.04, P Ͻ 0.01). MRI data of cyclists did not correlate to hemoglobin, erythrocyte, or reticulocyte counts; ferritin, relative heart volume, relative maximal power (rPmax; W/kg bw), or relative maximal oxygen consumption (VO 2 max). A borderline linear correlation was found for hematocrit (OOP: r ϭ 0.42, P ϭ 0.06; TIRM: r ϭ 0.44, P ϭ 0.06). Conclusion:Bone marrow hyperplasia is observed in male professional cyclists in the axial skeleton. The MR findings are probably independent of mechanically induced marrow edema. A multifactorial cause must be considered, as single laboratory and performance data did not appear to contribute significantly to these results.

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confidence: 63%

“…MAGNETIC RESONANCE IMAGING (MRI) of the spine has been established as an accurate noninvasive imaging modality for characterizing a variety of pathological and physiological conditions of bone marrow (1)(2)(3). Diseases that cause an increase of the cell count in hematopoietic bone marrow lead to chararcteristic MRI patterns (4).…”

mentioning

confidence: 99%

Characterization of hematopoietic bone marrow in male professional cyclists by magnetic resonance imaging of the lumbar spine

Altehoefer

Schmid

Büchert

et al. 2002

Magnetic Resonance Imaging

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“…15,16 In this context, the primary use of MRI to date has been to assess bone disease, extraosseous metastases, or paraspinal tumors to look for cord impingement. [16][17][18] Despite its increased use, to our knowledge there is no defined system to incorporate bone marrow imaging for routine patient evaluation and staging. The imaging techniques are not only subjective but also have not been validated uniformly with other established clinical or laboratory markers of disease.…”

Section: Discussionmentioning

confidence: 99%

Extent of disease burden determined with magnetic resonance imaging of the bone marrow is predictive of survival outcome in patients with multiple myeloma

Ailawadhi

Abdelhalim

Derby

et al. 2009

Cancer

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The final properties of the composites materials are strongly dependent on the residual aspect ratio, orientation, and distribution of the fibers, which are determined by the processing conditions. Present work is a systematic study of the influence of natural fiber concentration on its damage during all the steps involved in the composite compounding. The system under study is cellulose fiber‐reinforced polypropylene. The fiber geometrical parameters—length, diameter, and aspect ratio—are measured, and their statistical distributions are assessed for different concentrations. It is found that the higher the fiber concentration, the lower the fiber damage. These results evidence a difference in behavior between the damage of flexible natural fiber and rigid ones. The results are analyzed in terms of fiber concentration regimes, fiber–fiber interaction, flexibility, and entanglements. Two competitive mechanisms of the fiber interaction are proposed for explaining the fiber damage behavior during the flow of the flexible natural fiber suspensions. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 103: 2501–2506, 2007

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“…Previous studies have shown that MRI provides definite advantages compared to CT in demonstrating the extent of bone tumors in the extremities [1,5,6,7,10,12]. In particular, T1-weighted images are useful for such evaluation [4].…”

Section: Discussionmentioning

confidence: 99%

Preoperative estimation of metastatic vertebral tumors

Fujita

Ueda

Kawahara

et al. 2000

International Orthopaedics

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Total en bloc spondylectomy was performed in 22 patients with metastatic vertebral tumors. Osteolytic lesions were present in 15 cases while 7 cases had osteoblastic or mixed lesions. We measured the dimensions of the tumors preoperatively using magnetic resonance imaging (MRI) and computerized tomography (CT), and postoperatively by histological examination of the resected specimens. In the osteolytic group, the dorsoventral and transverse diameters of the metastatic tumor as measured on MRI were significantly greater compared to those determined by the histological examination. On the other hand, the same parameters measured by CT were smaller than the histologically determined dimensions. Although there were no significant differences between measurements of osteoblastic and osteolytic tumors, CT underestimated dimensions in osteoblastic or mixed tumors more than in those of osteolytic tumors. Estimation of tumor dimensions and local invasion using MRI and CT should be interpreted carefully.Résumé Une spondylectomie totale en bloc a été effectuée sur 22 patients atteints de tumeurs vertébrales métastati-ques. Des lésions ostéolytiques ont été décelées sur 15 sujets, tandis que les 7 autres présentaient des lésions ostéobl-astiques ou mixtes. Nous avons comparé les dimensions des tumeurs vertébrales métastatiques mesurées avant l'opération par IRM et TDM aux dimensions mesurées immédiatement après l'opération lors de l'examen histologique de prélèvements vertébraux. Pour le groupe souffrant de lésions ostéolytiques, les diamètre dorsoventral transversal relatif de la tumeur métastatique mesuré par le IRM était plus élevé que celui déterminé au cours de l'examen histologique. D'un autre côté, ces mêmes paramètres mesurés à l'aide des scanners TDM affichaient aussi une diffé-rence importante. Bien que les différences entre les mesures des tumeurs ostéoblastiques et ostéolytiques n'aient pas été très grandes, le TDM a sous-estimé les dimensions des tumeurs ostéoblastiques ou mixtes plus que les tumeurs ostéolytiques. Nos données suggèrent une interprétation prudente de l'estimation réalisée par le IRM et le TDM concernant les dimensions de tumeurs ainsi que l'invasion locale.

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MRI in the detection of malignant infiltration of bone marrow

Cited by 315 publications

References 13 publications

Characterization of hematopoietic bone marrow in male professional cyclists by magnetic resonance imaging of the lumbar spine

Characterization of hematopoietic bone marrow in male professional cyclists by magnetic resonance imaging of the lumbar spine

Extent of disease burden determined with magnetic resonance imaging of the bone marrow is predictive of survival outcome in patients with multiple myeloma

Preoperative estimation of metastatic vertebral tumors

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