MRI-guided transurethral ultrasound therapy of the prostate gland: simulations under clinical conditions

MRI-guided transurethral ultrasound therapy enables full prostate gland coagulation: Investigations in gel phantoms

“…The insertion of the rigid transurethral ultrasound applicator and rectal cooling device can alter the prostate shape and its location relative to other structures. The consideration of these components in the segmentation data enabled investigations of various strategies under realistic clinical conditions for optimizing treatment outcomes, in previous numerical simulations [9] as well as in this presented gel phantom study.…”

“…A multi-element heating applicator is rotated inside the urethra to generate a region of irreversible coagulation radially in the tissues [7][8][9][10]. The therapeutic ultrasound applicator is planar.…”

“…A preliminary in-vitro gel phantom study has shown the feasibility of full prostate treatment in canine anatomy which is the common animal model used for in-vivo preclinical validation [8]. Investigations have also been done in human anatomy in modeling [9]. This new preclinical study tests ultrasound exposures configurations and control options in vitro for achieving full human prostate treatments in clinical conditions.…”