MRI-Guided High–Dose-Rate Intracavitary Brachytherapy for Treatment of Cervical Cancer: The University of Pittsburgh Experience

Gill, Beant S.; Kim, Hayeon; Houser, Christopher J.; Kelley, Joseph L.; Sukumvanich, Paniti; Edwards, Robert P.; Comerci, John T.; Olawaiye, Alexander; Huang, Marilyn; Courtney‐Brooks, Madeleine; Beriwal, Sushil

doi:10.1016/j.ijrobp.2014.10.053

Cited by 131 publications

(70 citation statements)

References 31 publications

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“…All patients underwent image-guided brachytherapy; those treated prior to 2011 had MRI completed only with the first applicator placement and CT scans for each placement thereafter (CT/MR hybrid approach) [14,15]. Following this time period, patients underwent MRI with each applicator placement when possible.…”

Section: Magnetic Resonance Imagingmentioning

confidence: 99%

Cervical cancer outcome prediction to high-dose rate brachytherapy using quantitative magnetic resonance imaging analysis of tumor response to external beam radiotherapy

Minkoff

Gill

Kang

et al. 2015

Radiotherapy and Oncology

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Section: Magnetic Resonance Imagingmentioning

confidence: 99%

Cervical cancer outcome prediction to high-dose rate brachytherapy using quantitative magnetic resonance imaging analysis of tumor response to external beam radiotherapy

Minkoff

Gill

Kang

et al. 2015

Radiotherapy and Oncology

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“…There are an increasing number of published reports regarding treatment results of IGABT for cervical cancer as shown in Table 4 [8][9][10][11][12][14][15][16][17]. In 2011, Pötter et al retrospectively analyzed 156 patients with FIGO stage IB to IVA cervical cancer treated by IGABT at Medical University of Vienna [8].…”

Section: Reported Treatment Resultsmentioning

confidence: 99%

“…Increasing numbers of treatment results have been reported, and the impressive role of IGABT, especially in LC, has been demonstrated when delivering more than 80 Gy as a mean total HR-CTV D90s. Therefore, many representative institutions aimed at least more than 80 Gy [9][10][11][12][13]. Although MRI-based IGABT has been performed since September 2014 at Kobe University, CT-based IGABT still has been performed at most Japanese institutions because of various circumstances, and interstitial needles are less frequently used.…”

Section: Discussionmentioning

confidence: 99%

“…The treatment schedules at representative institutions are also shown in Table 2b for direct comparison with the Japanese protocol. CS technique is not used by all institutions [8][9][10][11][12].…”

Section: Treatment Schedule and Details Of Ebrtmentioning

confidence: 99%

“…Doses from PI with the CS technique are not included. As for these OARs, many previous studies used similar criteria [8][9][10]12]. …”

Section: Oarmentioning

confidence: 99%

See 2 more Smart Citations

Image‐Guided Adaptive Brachytherapy for Cervical Cancer Using Magnetic Resonance Imaging: Overview and Experience

Yoshida¹,

Nishikawa²,

Miyawaki³

et al. 2017

Radiotherapy

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Image-guided adaptive brachytherapy (IGABT) using magnetic resonance imaging (MRI) has been accepted as a novel treatment technique for cervical cancer. During the development of MRI-based IGABT, a very important concept called "High-risk clinical target volume (HR-CTV)" was introduced. However, computed tomography (CT)-based IGABT is the most common modality in Japan.MRI-based IGABT was initiated in September 2014 at Kobe University Hospital and 50 patients were treated through March 2016. Although a total HR-CTV D90 ranging from 80 to 85 Gy equivalent dose in 2 Gy fractions in combination with 45 Gy of external beam radiotherapy (EBRT) and 7 Gy×4 fractions of IGABT is the most standard treatment aim in European institutions, our aim for a total HR-CTV D90 was a 70-80 Gy because of the use of the central shielding technique for the protection of organs at risk in the late phase of EBRT.The mean total HR-CTV D90 for our 50 patients was 77 Gy. Although our aim was achieved, it was relatively low because Japanese radiotherapy protocols for cervical cancer still differ from those in European institutions. Therefore, a new treatment protocol, which is closer to the global standard, should be established.

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Imaging in the Management of Gynecologic Cancers

Meier

Sherertz

Paulson

et al. 2019

Practical Guides in Radiation Oncology

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MRI-Guided High–Dose-Rate Intracavitary Brachytherapy for Treatment of Cervical Cancer: The University of Pittsburgh Experience

Cited by 131 publications

References 31 publications

Cervical cancer outcome prediction to high-dose rate brachytherapy using quantitative magnetic resonance imaging analysis of tumor response to external beam radiotherapy

Cervical cancer outcome prediction to high-dose rate brachytherapy using quantitative magnetic resonance imaging analysis of tumor response to external beam radiotherapy

Image‐Guided Adaptive Brachytherapy for Cervical Cancer Using Magnetic Resonance Imaging: Overview and Experience

Imaging in the Management of Gynecologic Cancers

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