Mri guided focused ultrasound modulation of deep brain pain regions and circuits in nonhuman primates

Chen, Li Min; Yang, Pai‐Feng; Newton, Allen T.; Mishra, Arabinda; Manuel, Thomas J.; Luo, Huiwen; Sigona, Michelle K.; Gore, John C.; Grissom, William A.; Caskey, Charles F.

doi:10.1016/j.brs.2021.10.035

Cited by 2 publications

(2 citation statements)

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“…In addition, MRI or camera-based positioning system is necessary to ensure the efficacy and safety of ultrasound stimulation, which has been used to guide ultrasound stimulation in non-human primates or humans [13,20]. Additionally, magnetic resonance image-guided focused ultrasound (MRgFUS) stimulation system has been developed to precisely locate the focus of ultrasound in real time [45]. For rodent animals, we will explore 9.4T MRI-guided positioning system for guided ultrasound stimulation in further studies.…”

Section: Discussionmentioning

confidence: 99%

Ultrasound Deep Brain Stimulation Modulates Body Temperature in Mice

Pang

Wen

Zhong

et al. 2022

IEEE Trans. Neural Syst. Rehabil. Eng.

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Body temperature plays a critical role in rehabilitation, and numerous studies proved that the regulation of body temperature contributes to the sensorimotor recovery of patients with brain diseases such as stroke. The hypothalamus plays a key role in thermoregulation. Ultrasound deep brain stimulation (UDBS) can noninvasively modulate deep brain nuclei and have potential applications in the treatment of Parkinson's disease, Alzheimer's disease, and depression, among others. The purpose of this study was to investigate whether ultrasound stimulation of the hypothalamus could regulate body temperature in free-moving mice. Results showed that thermoregulation was related to ultrasonic parameters (pulse repetition frequency (PRF), duty cycle, total time, and acoustic pressure). UDBS of the preoptic area of the anterior hypothalamus at 500 Hz PRF could significantly reduce body temperature (ΔT = -0.25 ± 0.073 °C at t = 5 min, ΔT = -0.51 ± 0.19 °C at t = 10 min, ΔT = -0.84 ± 0.27 °C at t = 15 min). Meanwhile, UDBS of the dorsomedial hypothalamus at 10 Hz PRF triggered a significant increase in body temperature (ΔT = 0.5 ± 0.077 °C at t = 5 min, ΔT = 1.16 ± 0.23 °C at t = 10 min). These results suggest that UDBS, as a noninvasive neuromodulation tool, may play a key role in the future clinical treatment of malignant hyperthermia and hypothermia.

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Section: Discussionmentioning

confidence: 99%

Ultrasound Deep Brain Stimulation Modulates Body Temperature in Mice

Pang

Wen

Zhong

et al. 2022

IEEE Trans. Neural Syst. Rehabil. Eng.

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“…Capable of non-invasively modulating neuronal activities in specific brain regions [10][11][12][13][14][15] , tFUS holds promise in treating neurological disorders [16][17][18] . Notably, tFUS has been applied to managing pain by targeting specific brain circuits: stimulating the right anterior thalamus for antinociception in healthy individuals 19 , targeting the posterior frontal cortex to induce mood improvement in chronic pain patients 20 , modulating thalamus and periaqueductal gray (PAG) regions to reduce heat pain response in nonhuman primates 21 , and stimulating the PAG to attenuate formalin-mediated nociceptive activity in the spinal cord dorsal horn in rats 22 . Despite these promising applications in pain research, several fundamental questions remain.…”

Section: Introductionmentioning

confidence: 99%

Low-intensity transcranial focused ultrasound suppresses pain by modulating pain processing brain circuits

Kim

Fouda

et al. 2022

Preprint

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Despite enormous efforts made in clinical pain research, there is still a need to identify a novel non-pharmacological solution due to critical side-effects. Low-intensity transcranial focused ultrasound (tFUS) is an emerging non-invasive neuromodulation technology with high spatial specificity and deep brain penetration. Here, we demonstrate that tFUS stimulation at pain processing brain circuits significantly affects behavioral responses to noxious stimuli in in vivo mouse models. We developed a tightly-focused 128-element random array ultrasound transducer with a dynamic focus steering for targeting small mice brains, and found that a single-session tFUS to the primary somatosensory cortex (S1) attenuates heat pain sensitivity in wild-type mice, bidirectionally modulate thermal and mechanical hyperalgesia in humanized mouse model of sickle cell disease as a function of ultrasound pulse repetition frequency (PRF), and targeting deeper cortical structure (e.g., insula) led to a sustained behavioral change associated with heat hyperalgesia. Furthermore, we found that multi-session tFUS to S1 and insula resulted in a long-lasting suppression of heat pain-associated behaviors in older sickle mice and confirmed the safety of the tFUS protocol. These profound experimental evidence of tFUS-induced non-invasive modulation of pain-related behaviors from short- to long-term effects may facilitate the next-generation chronic pain treatment.

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Mri guided focused ultrasound modulation of deep brain pain regions and circuits in nonhuman primates

Cited by 2 publications

References 0 publications

Ultrasound Deep Brain Stimulation Modulates Body Temperature in Mice

Ultrasound Deep Brain Stimulation Modulates Body Temperature in Mice

Low-intensity transcranial focused ultrasound suppresses pain by modulating pain processing brain circuits

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