MRI free water mediates the association between water exchange rate across the blood brain barrier and executive function among older adults
Colleen Pappas,
Christopher E. Bauer,
Valentinos Zachariou
et al.
Abstract:Vascular risk factors contribute to cognitive aging, with one such risk factor being dysfunction of the blood brain barrier (BBB). Studies using non-invasive magnetic resonance imaging (MRI) techniques, such as diffusion prepared arterial spin labeling (DP-ASL), can estimate BBB function by measuring water exchange rate (kw). DP-ASL kw has been associated with cognition, but the directionality and strength of the relationship is still under investigation. An additional variable that measures water in extracell… Show more
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