MRI for Response Assessment In Oncologic Bone Marrow Lesions

Lecouvet, Frédéric; Omoumi, Patrick; Larbi, Ahmed; Tombal, Bertrand; Michoux, Nicolas; Berg, Bruno

doi:10.1007/174_2011_492

Cited by 2 publications

(1 citation statement)

References 103 publications

(116 reference statements)

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“…Therapy assessments using MRI allow precise evaluation of lesion size and number and metastatic growth pattern as well as treatment-induced signal changes in bony lesions. Moreover, functional information derived from DW-MRI is an important part of the oncological work-up, as this technique enables detection of changes in water diffusion and cellular density that occur after therapy (14). Thus, the aim of this paper is to discuss and highlight the diagnostic performance of MRI in the treatment assessment of bone metastases, to review the current literature, and to provide an overview of guidelines proposed for the response evaluation of bony disease.…”

Section: Introductionmentioning

confidence: 99%

Magnetic resonance imaging for assessing treatment response in bone marrow metastases

Switlyk

2019

Acta Radiol

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Cancer metastasis to bone is a frequent observation in malignancy that may result in complications such as pathological fractures and spinal cord compression. Monitoring treatment effects is the main concern in oncology; however, the evaluation of treatment response in bone is particularly challenging as it lacks well-established criteria. In addition, bone metastases have traditionally been considered non-measurable manifestations of cancer. Magnetic resonance imaging (MRI) is one of the most specific and sensitive methods for imaging skeletal metastases. The aim of this article is to highlight the diagnostic performance of MRI in the treatment monitoring of bone metastases, to review the current literature, and to provide an overview of recommendations for the evaluation of treatment response in bone.

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Section: Introductionmentioning

confidence: 99%

Magnetic resonance imaging for assessing treatment response in bone marrow metastases

Switlyk

2019

Acta Radiol

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Postoperative and posttherapeutic changes after primary bone tumors

Grieser¹,

Nöbauer-Huhmann

2017

Radiologe

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Posttreatment imaging of primary bone tumours represents a diagnostic challenge for radiologists. Depending on the primary bone tumour common radiological procedures, such as radiography, computed tomography (CT), and magnetic resonance imaging (MRI), are employed. Radiography and CT are particularly useful in benign bone tumours and in matrix-forming bone tumours. MRI comes into consideration with malignant tumour recurrence and tumoral soft tissue infiltration. Bone scintigraphy is of superior importance if a primarily multifocal manifestation of bone tumour or metastasizing tumour disease is suspected. Molecular imaging (FDG-PET and hybrid imaging, using CT) are gaining increasing importance in light of monitoring neoadjuvant chemotherapy and detecting recurrent tumour appearance. The current literature shows sensitivity and specificity values for recurrent detection of up to 92% and 93%. Diagnostic accuracy is as high as 95%, thus, exceeding accuracy values for CT (67%) and MRI (86%) by far. Likewise, this is also applicable for the assessment of the neoadjuvant chemotherapy. Moreover, PET-based modalities are able to establish prognostic statements using SUV-threshold values at baseline (especially for Ewing sarcomas). Advanced imaging techniques have made a great diagnostic step forward and have proven to be relevant and reproducible with respect to both relapse detection and treatment assessment. Furthermore, it is not clear whether a higher detection rate of early tumour recurrence will inevitably lead to better outcome and survival.

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MRI for Response Assessment In Oncologic Bone Marrow Lesions

Cited by 2 publications

References 103 publications

Magnetic resonance imaging for assessing treatment response in bone marrow metastases

Magnetic resonance imaging for assessing treatment response in bone marrow metastases

Postoperative and posttherapeutic changes after primary bone tumors

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