MRI for Crohn’s Disease: Present and Future

Yoon, Kichul; Chang, Kyu‐Tae; Lee, Hong J.

doi:10.1155/2015/786802

Cited by 25 publications

(28 citation statements)

References 93 publications

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“…Treatment of acute inflammation is via medical approaches while the required treatment for fibrostenotic disease is surgery. 29 , 30 There are various structural and functional factors for assessing active disease in MRE. These factors include wall thickening, higher degree and pattern of enhancement, intensity of T2 mural signal, local lymph node enhancement, higher mesenteric vascularity that are known to be correlated with laboratory data, endoscopic results or histological activity of CD.…”

Section: Discussionmentioning

confidence: 99%

The Diagnostic Role of Magnetic Resonance Enterography as a Complementary Test to Colonoscopy in Active Crohn’s Disease

Arian

Azizi

Teimouri

et al. 2016

Middle East J Dig Dis

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BACKGROUND According to recent studies comparing magnetic resonance enterography (MRE) with ileocolonoscopy for assessing inflammation of small bowel and colonic segments in adults with active Crohn’s disease (CD), we aimed to compare the accuracy of these two diagnostic methods in Iranian population. METHODS During 2013-2014 a follow-up study was done on 30 patients with active CD in a gastroenterology clinic affiliated to Tehran University of Medical Sciences. MRE and ileocolonoscopy were performed for all the patients. All statistical analyses were performed using SPSS (version 18) and p-value<0.05 was considered as statistically significant. RESULTS Of the 30 patients with active CD, 11(36.7%) were men and 19 (63.3%) were women with mean age of 37.30±13.66 years (range: 19-67 years). MRE had sensitivity and specificity of 50% and 90% with positive predictive value (PPV) and negative predictive value (NPV) of 71.43 and 78.26, respectively for localizing sigmoid lesions and ileum had sensitivity and specificity of 84.21 and 45.45 with PPV and NPV of 72.73 and 62.50, respectively. CONCLUSION While moderate sensitivity and high specificity of MRE in localizing colonic lesions makes it an appropriate confirmatory test after colonoscopy, the reported high sensitivity and moderate specificity of MRE versus colonoscopy in detecting ileal lesions makes it a suitable screening test for ileal lesions. Finally we can conclude that MRE can be an important complementary test to colonoscopy in detecting active disease.

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Section: Discussionmentioning

confidence: 99%

The Diagnostic Role of Magnetic Resonance Enterography as a Complementary Test to Colonoscopy in Active Crohn’s Disease

Arian

Azizi

Teimouri

et al. 2016

Middle East J Dig Dis

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“…Kronova bolest je hronična inflamatorna bolest creva, progresivnog toka, sa najvećom incidencom javljanja između druge i četvrte decenije života (1), a čiji tok karakterišu remisije i relapsi (2,3,4). Dijagnoza Kronove bolesti se postavlja na osnovu anamneze i fizikalnog pregleda, kao i laboratorijskih, endoskopskih i radioloških nalaza (5). U dijagnozi Kronove bolesti, posebno kod dece, neophodan je balans između preciznosti vizualizacionih metoda sa jedne strane, i neškodljivosti i lake izvodljivosti s druge strane.…”

Section: Uvodunclassified

Ultrasound and magnetic resonance enterography in diagnosis of Crohn's disease in children

Cvejić¹,

Filipović²,

Pavićević³

et al. 2018

Medicinski podmladak

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Introduction: Crohn's disease is a chronic inflammatory bowel disease, which is characterized by remitting and relapsing episodes, and commonly affects younger than 30. Magnetic resonance enterography (MRE) and ultrasound (US) are taking the leading role over colonoscopy and computed tomography (CT) in diagnostics, initial estimation of Crohn's disease and monitoring of activity, detection and evaluation of complications. Aim: To examine sensitivity (SE), specificity (SP), positive predictive value (PPV), negative predictive value (NPV) of US and MRE in diagnosis of Crohn's disease. Also, to examine overall diagnostic value of MRE comparing morphological and functional parameters with endoscopic findings. Material and methods: 40 patients were observed from the end of year 2009 to the end of 2016. Diagnosed patients with clinical and laboratory findings were sent for US and MRE examination. US evaluated wall thickness, mesenteric fibrofatty proliferation and enlargement of mesenteric lymph nodes. Beside this, MRE also evaluated bowel wall enhancement and layered enhancement pattern. Results: Overall diagnostic value of morphological and functional parameters on the MRE has a SE of 58.3% and SP of 100% if we want to confirm the diagnosis, and SE 87.5% and SP of 80% if we want to exclude the diagnosis. There was statistically significant correlation between the increased wall thickness and the accumulation of fat in the mesentery on MRE, and the gold standard (colonoscopy/histopathology, clinical presentation and laboratory findings).Correlation between results on US and MRE shows statistical significance in diagnostics of Crohn's disease in ileum, terminal ileum, Bauchini valve and cecum, ascendant colon in children. It showed high specificity (SP) for both diagnostic procedures in almost all segments (maximum value 94,7%). Sensitivity (SE) varied from 0 to 83,3% in different bowel segments. Conclusion: Our study showed that it is reliable to use MRE and US to exclude those who don't have Crohn's disease. Also, combination of morphological and functional parameters on MRE could be used in confirming and monitoring Crohn's disease.

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“…Intramural edema: This is a typical sign of active inflammation resulting in submucosal thickening, which appears as hyperintensity on T2-weighted (SSFSE) images with fat saturation[26]. …”

Section: Mr Enterography Indicationsmentioning

confidence: 99%

Magnetic resonance enterography in Crohn’s disease: How we do it and common imaging findings

Mantarro¹,

Scalise²,

Guidi³

et al. 2017

WJR

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Crohn’s disease (CD) is a chronic inflammatory disease of the gastrointestinal tract, with unpredictable clinical course by phases of relapses alternating with other of quiescence. The etiology is multifactorial and is still not completely known; globally the westernization of lifestyle is causing an increasing incidence of CD, with peak age of 20-30 years. The diagnostic workup begins with the evaluation of the clinical history, physical examination and laboratory tests. However, the clinical assessment is subjected interobserver variability and, occasionally, the symptoms of acute and chronic inflammation may be indistinguishable. In this regards, the role of magnetic resonance (MR) enterography is crucial to determine the extension, the disease activity and the presence of any complications without ionizing radiations, making this method very suitable for young population affected by CD. The purpose of this review article is to illustrate the MR enterography technique and the most relevant imaging findings of CD, allowing the detection of small bowel involvement and the assessment of disease activity.

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MRI for Crohn’s Disease: Present and Future

Cited by 25 publications

References 93 publications

The Diagnostic Role of Magnetic Resonance Enterography as a Complementary Test to Colonoscopy in Active Crohn’s Disease

The Diagnostic Role of Magnetic Resonance Enterography as a Complementary Test to Colonoscopy in Active Crohn’s Disease

Ultrasound and magnetic resonance enterography in diagnosis of Crohn's disease in children

Magnetic resonance enterography in Crohn’s disease: How we do it and common imaging findings

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