MRI findings of olivary degeneration after surgery for posterior fossa tumours in children: incidence, time course and correlation with tumour grading

Tartaglione, Tommaso; Izzo, Giana; Alexandre, Andrea; Botto, Annibale; Lella, Giuseppe Maria Di; Gaudino, Simona; Caldarelli, Massimo; Colosimo, Cesare

doi:10.1007/s11547-014-0477-x

Cited by 16 publications

(8 citation statements)

References 22 publications

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“…The etiology of CP was not explored in relation to motor planning, despite the fact that its impact on motor function has been established [120][121][122][123][124][125][126][127][128][129][130][131][132]. This is further supported by studies on other pediatric populations which have shown that damage to certain neurological networks is associated with motor planning deficits in children with tumors [133,134] or in children with neurodevelopmental disorders [135,136]. In addition, the results in bilateral tasks cannot be compared to those of unilateral tasks as both types of tasks rely on different neural networks [137,138].…”

Section: Discussionmentioning

confidence: 99%

Upper Limb Motor Planning in Individuals with Cerebral Palsy Aged between 3 and 21 Years Old: A Systematic Review

et al. 2021

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Individuals with cerebral palsy have difficulties performing activities of daily living. Beyond motor execution impairments, they exhibit motor planning deficits contributing to their difficulties. The objective of this review is to synthesize the behavioral evidence of motor planning deficits during an upper limb motor task in children, adolescents and young adults with cerebral palsy aged between 3 and 21 years. Methods: The inclusion criteria were: (1) including individuals with cerebral palsy from 3 to 21 years old; (2) assessing upper limb motor planning. Six databases were screened. The quality assessment of the studies was performed. Results: Forty-six studies and 686 participants were included. Five articles have been identified as very high quality, 12 as high, 20 as moderate, six as low, three as very low. Force planning studies reported a deficit for the more affected hand but adequate performances for the less affected hand. Object-manipulation studies reported hand posture planning deficits irrespectively of the hand assessed. Conclusions: Motor planning deficits has been shown in the more affected hand for force scaling, while the results for other variables showed overall deficits. Hence, variables affected by motor planning deficits in both hands should be considered in children with cerebral palsy to optimize intervention.

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Section: Discussionmentioning

confidence: 99%

Upper Limb Motor Planning in Individuals with Cerebral Palsy Aged between 3 and 21 Years Old: A Systematic Review

et al. 2021

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“…This phenomenon is of particular importance in neoplastic etiologies of HOD, such as described in our patient, as the new area of hypertrophy should not be confused for a tumoral lesion. The abnormality may be either unilateral or bilateral depending on the location of the lesion [ 10 ]. On MRI, HOD is described as a non-contrast enhancing T1 isointense lesion and a T2/FLAIR hyperintense lesion restricted to the ION [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

“…HOD represents a diagnostic challenge, particularly in cases involving neoplastic processes, as it may be confused with tumor metastasis or recurrence. The neurosurgical literature concerning HOD is limited, particularly in pediatric patients [9,10].…”

Section: Introductionmentioning

confidence: 99%

Temporal Evolution of Hypertrophic Olivary Degeneration in a Pediatric Patient: A Case Report and Review of Literature

Torres

Vicenty-Padilla

Cay-Martínez

et al. 2020

Cureus

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Hypertrophic olivary degeneration (HOD) is a rare type of neuronal degeneration seen after interruption of the dentato-rubro-olivary tract also known as the Guillain-Mollaret triangle (GMT). It is associated with hypertrophic changes of the inferior olive. Commonly reported in adults, this lesion presents with ataxia and oculopalatal myoclonus. Up to date, few cases have been published in the literature that refer to pediatric cases. This diagnosis is particularly important in the setting of brainstem tumor surgery as it should not be confused for tumor recurrence or metastasis, in turn avoiding unwarranted surgical intervention. We present the case of a 15-year-old male who underwent resection of a left superior cerebellar peduncle (SCP) pilocytic astrocytoma. On follow-up, magnetic resonance imaging (MRI) demonstrated evidence of mild residual tumor as well as progressive engorgement of the inferior olivary nucleus (ION). The patient was clinically asymptomatic and has since been observed expectantly without any issues. We were able to pinpoint the most probable location of injury in our patient's GMT. HOD remains a somewhat obscure entity. Its presentation may be early and not accompanied by significant neurologic findings, in contrast to what has been previously reported. Particularly in neoplastic cases, it may represent a diagnostic challenge and could be easily confused for tumor recurrence. A multidisciplinary approach for this entity, as with other pathologies, is of particular importance. Its proper recognition will result in the best outcomes for the patient.

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“…Apart from these primary causes, surgical manipulation of the posterior fossa is a well-known cause of subsequent HOD (Uchino et al, 1993;Phatouros and McConachie, 1998;Tsui et al, 1999;Harter and Davis, 2004;Akar et al, 2008;Hornyak et al, 2008;Gatlin et al, 2011;Yun et al, 2013;Tartaglione et al, 2015). Tartaglione et al (2015) reviewed the imaging findings in 58 children after surgery for posterior fossa tumors and found T2 signal changes in 33% of the cases and olivary enlargement in 36% of them. The changes were visible between 1 and 6 months after surgery with a tendency to decrease and becoming faint after 12 months.…”

Section: Discussionmentioning

confidence: 99%

The dentato–rubro–olivary pathway revisited: New MR imaging observations regarding hypertrophic olivary degeneration

et al. 2017

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Hypertrophic olivary degeneration (HOD) following a lesion of the dentato-rubro-olivary pathway (DROP) is a well-known imaging finding and has extensively been described in the recent literature. We reviewed our patients with HOD as a result of a lesion of the DROP in order to analyze the disruption of the DROP and the resulting HOD in comparison with the literature. We observed unusual imaging findings in four patients. In two patients it concerned new observations related to the timing and imaging appearances of HOD. HOD became only visible 6 years after a lesion in the red nucleus in one patient and a cystic degeneration of the olivary nucleus was seen 3 years after the HOD in a second patient. In two patients we found HOD that could only be explained by the existence of an afferent feedback loop between the dentate nucleus and the inferior olivary nucleus and by the knowledge that these fibers run through the ipsilateral olivary nucleus before ending in the contralateral olivary nucleus. In one of these patients the lesion was located in the inferior cerebellar peduncle. In the other patient the lesion was located on the midline in the medulla oblongata. The imaging findings in these patients reveal new observations in the stages of imaging appearances in HOD and shed light on the forgotten dentato-olivary afferent feedback loop of the DROP. Clin. Anat. 30:543-549, 2017. © 2017 Wiley Periodicals, Inc.

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MRI findings of olivary degeneration after surgery for posterior fossa tumours in children: incidence, time course and correlation with tumour grading

Abstract: Our results demonstrate that olivary degeneration, with or without hypertrophy, is a relatively frequent consequence of posterior fossa surgery, particularly in children treated for high-grade tumours. Knowledge of this condition can prevent misdiagnoses and unnecessary investigations.

Cited by 16 publications

References 22 publications

Upper Limb Motor Planning in Individuals with Cerebral Palsy Aged between 3 and 21 Years Old: A Systematic Review

Upper Limb Motor Planning in Individuals with Cerebral Palsy Aged between 3 and 21 Years Old: A Systematic Review

Temporal Evolution of Hypertrophic Olivary Degeneration in a Pediatric Patient: A Case Report and Review of Literature

The dentato–rubro–olivary pathway revisited: New MR imaging observations regarding hypertrophic olivary degeneration

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