MRI evaluation of thermal ablation of tumors with focused ultrasound

McDannold, Nathan; Hynynen, Kullervo; Wolf, David E.; Wolf, Gerald; Jólesz, Ferenc A.

doi:10.1002/jmri.1880080119

Cited by 161 publications

(110 citation statements)

References 18 publications

(6 reference statements)

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“…It can monitor induced temperature changes (5,6) and evaluate treatment effects (7). The feasibility of MR-guided FUS to ablate tissue in vivo has been demonstrated in normal tissues (8Ϫ10), experimental animal tumors (11,12), and recently in clinical studies of breast tumors (13,14) and uterine fibroids (15).…”

Section: High-intensity Focused Ultrasound (Fus)mentioning

confidence: 99%

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Prediction of subtle thermal histopathological change using a novel analysis of Gd‐DTPA kinetics

Cheng

Purcell

Bilbao

et al. 2003

Magnetic Resonance Imaging

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Purpose: To investigate Gd-DTPA kinetics as predictors of histopathological changes following focused ultrasound (FUS) thermal ablation for improved planning and assessment. Materials and Methods:Twenty-nine FUS lesions were created in the thigh muscle of eight rabbits under MRguidance at 1.5 Tesla. Three rabbits were killed at four hours; and 11 lesions were analyzed with histopathology. Temperature-sensitive MRI using proton-resonant frequency-shift was used for time-dependent temperature measurements. Analysis of the uptake kinetics of Gd-DTPA was performed after Gd-DTPA injection, within 20 minutes after heating and again at two hours after heating. The resulting kinetic maps, permeability (K trans ) and leakage space (v e ), were correlated to peak temperatures, T 2 -weighted MR, and histopathology.Results: Images of K trans and v e reveal regions of histopathological change not visible on conventional posttherapy MR. At early times after heating, v e predicts the area of injury more accurately than T 2 (7 Ϯ 2% vs. 25 Ϯ 6% underestimation). A circular region of extensive structural/ vascular disruption is indicated only on K trans maps. The sharp decrease in K trans at the boundary of this region occurs at 47.5 Ϯ 0.5°C, and may be a better estimate of cell death than the conventional method of temperature threshold (55°C for coagulation) used in therapy planning. Conclusion:Our results suggest Gd-DTPA kinetics can predict different histopathological changes following FUS ablation and may be valuable for early prediction.

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Section: High-intensity Focused Ultrasound (Fus)mentioning

confidence: 99%

“…Thermal lesions usually appear with a dark center surrounded by a bright ring on posttherapy MRI (7,18), and many studies have shown that lesion depiction is clear (4,7,10,11,18). However, a few exceptions exist.…”

Section: High-intensity Focused Ultrasound (Fus)mentioning

confidence: 99%

Prediction of subtle thermal histopathological change using a novel analysis of Gd‐DTPA kinetics

Cheng

Purcell

Bilbao

et al. 2003

Magnetic Resonance Imaging

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“…Very small lesions can be targeted by this approach. Therefore, high-resolution imaging techniques, such as MRI, need to be used for accurate detection and monitoring [32,33]. FUS has been used to treat fibroadenomas in nine women under local anesthesia.…”

Section: Focused Ultrasound Ablationmentioning

confidence: 99%

Minimally Invasive Approaches for Diagnosis and Treatment of Early-Stage Breast Cancer

Vlastos

Verkooijen

2007

The Oncologist

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LEARNING OBJECTIVESAfter completing this course, the reader will be able to:1. Describe the minimally invasive approaches to breast cancer diagnosis and treatment.2. List the strengths and weaknesses of minimally invasive diagnostic and treatment procedures.3. Select appropriate patients for minimally invasive approaches to breast cancer diagnosis and treatment.Access and take the CME test online and receive 1 AMA PRA Category 1 Credit ™ at CME.TheOncologist.com CME CME ABSTRACTBreast cancer management has been evolving toward minimally invasive approaches. Image-guided percutaneous biopsy techniques provide accurate histologic diagnosis without the need for surgical biopsy. Breast conservation therapy has become the treatment standard for earlystage breast cancer. Sentinel lymph node biopsy is a new procedure that can predict axillary lymph node status without the need of axillary lymph node dissection. The next challenge is to treat primary tumors without surgery. For this purpose, several new minimally invasive procedures, including radiofrequency ablation, interstitial laser ablation, focused ultrasound ablation, and cryotherapy, are currently under development and may offer effective tumor management and provide treatment options that are psychologically and cosmetically more acceptable to the patients than are traditional surgical therapies. In this review, we give an overview of minimally invasive approaches for the diagnostic and therapeutic management of early-stage breast cancer. The Oncologist 2007;12: [1][2][3][4][5][6][7][8][9][10]

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“…Several investigators have used MRI to measure temperature elevation during thermal therapy. [205][206][207][208][209][210][211][212][213] …”

Section: Operationmentioning

confidence: 99%

Thermal Therapy, Part IV: Electromagnetic and Thermal Dosimetry

Habash

Bansal

Krewski

et al. 2007

Crit Rev Biomed Eng

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ABSTRACT:In this article some of the important techniques in electromagnetic (EM) and thermal dosimetry are reviewed. Three major areas are discussed: modeling power deposition and estimation of EM energy absorbed by tissues exposed to EM radiation, electrical-thermal modeling for thermal therapy with various models of heat transfer in living tissues, and thermal dosimetry using invasive and noninvasive thermometry. Knowledge about the temperature distributions achieved can only be obtained by treatment planning of patient therapy. This process is called thermal therapy planning system (TTPS), which is a large and complex system for design, control, documentation, and evaluation of the treatment that also provides data for treatment optimization. Various imaging techniques for guidance and monitoring necessary for clinical treatments are also discussed. The review concludes by suggesting future avenues for investigations.

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MRI evaluation of thermal ablation of tumors with focused ultrasound

Cited by 161 publications

References 18 publications

Prediction of subtle thermal histopathological change using a novel analysis of Gd‐DTPA kinetics

Prediction of subtle thermal histopathological change using a novel analysis of Gd‐DTPA kinetics

Minimally Invasive Approaches for Diagnosis and Treatment of Early-Stage Breast Cancer

Thermal Therapy, Part IV: Electromagnetic and Thermal Dosimetry

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