MRI evaluation of solid soft tissue masses of the fingers with pathology correlation

Serhal, Ali; Samet, Jonathan D.; Shah, Chirag; Omar, Imran M.; Youngner, Jonathan M.

doi:10.1016/j.ejrad.2020.109465

Cited by 5 publications

(3 citation statements)

References 27 publications

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“…The nodularity was established according to the Al-Qattan classification as either type I (single), i.e., a single round or multilobulated tumor, or type II (multinodular), i.e., exhibiting ≥2 distinct, separated tumors [ 27 , 28 ]. The margin was classified as circumscribed when the border was clearly delineated from surrounding structures or infiltrative if the borders were indistinguishable with surrounding structures [ 29 ]. The peripheral hypointensity was evaluated on T2-weighted image and defined as presence or absence.…”

Section: Methodsmentioning

confidence: 99%

Prediction of local recurrence in tenosynovial giant cell tumor of the knee: Based on preoperative MRI evaluation into disease subtypes and severity

Kim,

Lee,

Kim

2023

PLoS ONE

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Objective Tenosynovial giant cell tumors (TSGCTs) of the knee differ in their clinical outcome according to disease subtypes and severity. The aim of this study was to determine the predictive MRI features related to local recurrence in TSGCT of the knee regarding disease subtypes and severity. Methods This retrospective study included 20 patients with pathology-proven TSGCT of the knee who underwent preoperative MRI and surgery from Jan. 2007 to Jan. 2022. The anatomical point of the lesion was determined with a knee mapping. And then MRI features related to disease subtype including nodularity (single vs. multinodular); margin (circumscribed vs. infiltrative); peripheral hypointenseity (present vs. absent); internal hypointensity reflecting hemosiderin deposition (speckled vs. granular) were assessed. Third, MRI features related to disease severity including involvement of bone, cartilage, and tendon were evaluated. MRI features for predicting local recurrence of TSGCT were tested using chi-square test and logistic regression analysis. Results Ten patients with diffuse-type TSGCT (D-TSGCT) and 10 patients with localized-type TSGCT (L-TSGCT) were included. There were six cases of local recurrence and all of them were D-TSGCT and none for L-TSGCT with statistical difference (P = 0.015). D-TSGCT that was direct risk factor for local recurrence showed more multinodular (80.0% vs. 10.0%; P = 0.007), infiltrative margin (90.0% vs. 10.0%; P = 0.002), and absent peripheral hypointensity (100.0% vs. 20.0%; P = 0.001) than L-TSGCT. Multivariate analysis showed infiltrative margin (odds ratio [OR], 81.0; P = 0.003) was independent MRI factor for D-TSGCT. Disease severity for risk of local recurrence included cartilage (66.7% vs. 7.1%; P = 0.024) and tendon (100.0% vs. 28.6%; P = 0.015) involvement compared to no local recurrence. Multivariate analysis showed tendon involvement (OR, 12.5; P = 0.042) was predictive MRI parameter for local recurrence. By combining tumor margin and tendon involvement, local recurrence was predicted sensitively on preoperative MRI (sensitivity, 100%; specificity, 50%; accuracy, 65%). Conclusion D-TSGCTs was associated with local recurrence and showed multinodularity infiltrative margin, and absent peripheral hypointensity. Disease severity including cartilage and tendon involvement was associated with local recurrence. Preoperative MRI evaluation by combining disease subtypes and severity can predict local recurrence sensitively.

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Section: Methodsmentioning

confidence: 99%

Prediction of local recurrence in tenosynovial giant cell tumor of the knee: Based on preoperative MRI evaluation into disease subtypes and severity

Kim,

Lee,

Kim

2023

PLoS ONE

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Section: Morphological Findings For D-tsgctmentioning

confidence: 99%

“…Nodularity was classified according to Al Qattan as type I, representing "a single round or multilobulated tumor" or type II, indicating "two or more distinct, separated tumors" [29]. The margin was categorized as "circumscribed" when the lesion's border was clearly delineated from surrounding structures and as "infiltrative" if the lesion's borders were indistinguishable from the surrounding structures [30]. The study revealed that intra-articular D-TSGCT manifests as multinodular masses scattered throughout the joint, with multinodularity potentially serving as the sole indicator for determining mass features in intra-articular D-TSGCT (Figure 3) [28].…”

Section: Morphological Findings For D-tsgctmentioning

confidence: 99%

Diffuse-Type Tenosynovial Giant Cell Tumor: What Are the Important Findings on the Initial and Follow-Up MRI?

Choi,

Lee,

Kim

et al. 2024

Cancers

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Tenosynovial giant cell tumor (TSGCT) is a rare soft tissue tumor that involves the synovial lining of joints, bursae, and tendon sheaths, primarily affecting young patients (usually in the fourth decade of life). The tumor comprises two subtypes: the localized type (L-TSGCT) and the diffuse type (D-TSGCT). Although these subtypes share histological and genetic similarities, they present a different prognosis. D-TSGCT tends to exhibit local aggressiveness and a higher recurrence rate compared to L-TSGCT. Magnetic resonance imaging (MRI) is the preferred diagnostic tool for both the initial diagnosis and for treatment planning. When interpreting the initial MRI of a suspected TSGCT, it is essential to consider: (i) the characteristic findings of TSGCT—evident as low to intermediate signal intensity on both T1- and T2-weighted images, with a blooming artifact on gradient-echo sequences due to hemosiderin deposition; (ii) the possibility of D-TSGCT—extensive involvement of the synovial membrane with infiltrative margin; and (iii) the resectability and extent—if resectable, synovectomy is performed; if not, a novel systemic therapy involving colony-stimulating factor 1 receptor inhibitors is administered. In the interpretation of follow-up MRIs of D-TSGCTs after treatment, it is crucial to consider both tumor recurrence and potential complications such as osteoarthritis after surgery as well as the treatment response after systemic treatment. Given its prevalence in young adult patents and significant impact on patients’ quality of life, clinical trials exploring new agents targeting D-TSGCT are currently underway. Consequently, understanding the characteristic MRI findings of D-TSGCT before and after treatment is imperative.

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Tenosynovial giant cell tumors of digits: MRI differentiation between localized types and diffuse types with pathology correlation

et al. 2022

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MRI evaluation of solid soft tissue masses of the fingers with pathology correlation

Cited by 5 publications

References 27 publications

Prediction of local recurrence in tenosynovial giant cell tumor of the knee: Based on preoperative MRI evaluation into disease subtypes and severity

Prediction of local recurrence in tenosynovial giant cell tumor of the knee: Based on preoperative MRI evaluation into disease subtypes and severity

Diffuse-Type Tenosynovial Giant Cell Tumor: What Are the Important Findings on the Initial and Follow-Up MRI?

Tenosynovial giant cell tumors of digits: MRI differentiation between localized types and diffuse types with pathology correlation

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