MRI Estimation of Global Brain Oxygen Consumption Rate

Abstract

Journal of Cerebral Blood Flow & Metabolism (2010) 30, 1598–1607; doi:10.1038/jcbfm.2010.49; published online 21 April 2010 Following the publication of this issue, the editors noticed that the cover figure for the September 2010 issue was incorrect. The correct version appears below. Please note that this figure was created by the authors of the above article and is credited to them in the issue.

Absolute quantification of resting oxygen metabolism and metabolic reactivity during functional activation using QUO2 MRI

“…Literature MRI estimates of baseline OEF and CMRO 2 are not available for the visual cortex, but the value we observe for occipital cortex is well within the range observed for grey matter or whole brain, with values of 132 ±20 μmol/100 g/min (Xu et al, 2009), 125± 15 μmol/100 g/min (Bolar et al, 2011a), 127±6 (Jain et al, 2010), 151± 15 μmol/100 g/min (Fan et al, 2011) and 155±39 μmol/100 g/min (Bulte et al, 2011) for MRI-derived estimates. This is also true of PET-derived grey-matter values, as indicated by a survey of literature PET values in Xu et al (2009) showing values in young subjects spanning the range from 110.2± 19.6 μmol/100 g/min to 149.5± 27.5 μmol/100 g/min (Coles et al, 2006;Hattori et al, 2004;Ibaraki et al, 2008Ibaraki et al, , 2010Ishii et al, 1996;Ito et al, 2004Ito et al, , 2005.…”

“…While other MRI methods exist to obtain an estimate of these parameters (Bolar et al, 2011b;Bulte et al, 2011;Chiarelli et al, 2007;Davis et al, 1998;Fan et al, 2011;He and Yablonskiy, 2007;Jain et al, 2010;Xu et al, 2009), all methods rely on complex modeling and a certain number of assumptions. The M parameter is specific to MRI, since it represents the magnetic properties of baseline deoxyhemoglobin content, but nuclear medicine techniques can be used to assess oxidative metabolism.…”

Investigation of BOLD fMRI resonance frequency shifts and quantitative susceptibility changes at 7 T

“…The method employed here to estimate the changes in the blood fractional oxygen saturation from standard gradient-echo EPI images complements previous work measuring baseline values in large vessels by means of gradient-recalled-echo structural images [Jain et al, 2010;Fan et al, 2012]. It is also an improvement in terms of temporal resolution with regard to previous work measuring changes in blood fractional oxygen saturation in large vessels by means of gradient-recalled-echo images under steady state conditions [Haacke et al, 1997].…”

Decreased oxygen saturation in asymmetrically prominent cortical veins in patients with cerebral ischemic stroke

“…Understanding the difference in blood oxygen saturation between arteries and veins (Ya-Yv) could provide key information about cerebral oxygen demand and supply [10,11] of normal and diseased tissues. Previous MR studies to measure oxygen saturation have included T2 [12], T2* [13] and phase based methods [11,14,15].…”