MRI criteria for the diagnosis of multiple sclerosis: MAGNIMS consensus guidelines

Filippi, Massimo; Rocca, Maria A.; Ciccarelli, Olga; Stefano, Nicola De; Evangelou, Nikos; Kappos, Ludwig; Rovira, Àlex; Sastre‐Garriga, Jaume; Tintoré, Mar; Frederiksen, Jette Lautrup; Gasperini, Claudio; Palace, Jacqueline; Reich, Daniel S.; Banwell, Brenda; Montalbán, Xavier; Barkhof, Frederik

doi:10.1016/s1474-4422(15)00393-2

Cited by 698 publications

(614 citation statements)

References 91 publications

Supporting

Mentioning

576

Contrasting

Unclassified

Order By: Relevance

“…However, in line with the recommendations of the recently published MAGNIMS consensus guidelines,21 we suggest that spinal cord MRI should be included in the diagnostic workup if the presenting symptoms indicate spinal cord involvement. Furthermore, spinal MRI can be helpful in the differential diagnosis when brain imaging is equivocal or inconclusive and when brain MRI findings suggest radiologically isolated syndrome (RIS) 21, 34…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Guidelines for the use of magnetic resonance imaging in diagnosing and monitoring the treatment of multiple sclerosis: recommendations of the Swedish Multiple Sclerosis Association and the Swedish Neuroradiological Society

et al. 2016

View full text Add to dashboard Cite

Multiple sclerosis (MS) is associated with inflammatory lesions in the brain and spinal cord. The detection of such inflammatory lesions using magnetic resonance imaging (MRI) is important in the consideration of the diagnosis and differential diagnoses of MS, as well as in the monitoring of disease activity and predicting treatment efficacy. Although there is strong evidence supporting the use of MRI for both the diagnosis and monitoring of disease activity, there is a lack of evidence regarding which MRI protocols to use, the frequency of examinations, and in what clinical situations to consider MRI examination. A national workshop to discuss these issues was held in Stockholm, Sweden, in August 2015, which resulted in a Swedish consensus statement regarding the use of MRI in the care of individuals with MS. The aim of this consensus statement is to provide practical advice for the use of MRI in this setting. The recommendations are based on a review of relevant literature and the clinical experience of workshop attendees. It is our hope that these recommendations will benefit individuals with MS and guide healthcare professionals responsible for their care.

show abstract

Section: Resultsmentioning

confidence: 99%

“…The MAGNIMS collaboration has recently published suggestions for adjustments34 to the current McDonald criteria for the diagnosis of MS, last revised in 2010 5. Some important points in the suggested adjustments are the recommendations to:…”

Section: Resultsmentioning

confidence: 99%

Guidelines for the use of magnetic resonance imaging in diagnosing and monitoring the treatment of multiple sclerosis: recommendations of the Swedish Multiple Sclerosis Association and the Swedish Neuroradiological Society

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Specifically, the central vein sign alone or in combination with available MS diagnostic MRI criteria7, 28 improves the diagnostic accuracy and specificity, without lowering the sensitivity, of MS diagnosis. Assessments were performed on standard clinical magnetic field strength systems, and results at 3T and the more widely available 1.5T were indistinguishable.…”

Section: Discussionmentioning

confidence: 99%

Central vein sign differentiates Multiple Sclerosis from central nervous system inflammatory vasculopathies

Maggi

Absinta

Grammatico

et al. 2018

Annals of Neurology

Self Cite

166

186

View full text Add to dashboard Cite

ObjectivesIn multiple sclerosis (MS), magnetic resonance imaging (MRI) is a sensitive tool for detecting white matter lesions, but its diagnostic specificity is still suboptimal; ambiguous cases are frequent in clinical practice. Detection of perivenular lesions in the brain (the “central vein sign”) improves the pathological specificity of MS diagnosis, but comprehensive evaluation of this MRI biomarker in MS‐mimicking inflammatory and/or autoimmune diseases, such as central nervous system (CNS) inflammatory vasculopathies, is lacking. In a multicenter study, we assessed the frequency of perivenular lesions in MS versus systemic autoimmune diseases with CNS involvement and primary angiitis of the CNS (PACNS).MethodsIn 31 patients with inflammatory CNS vasculopathies and 52 with relapsing–remitting MS, 3‐dimensional T2*‐weighted and T2–fluid‐attenuated inversion recovery images were obtained during a single MRI acquisition after gadolinium injection. For each lesion, the central vein sign was evaluated according to consensus guidelines. For each patient, lesion count, volume, and brain location, as well as fulfillment of dissemination in space MRI criteria, were assessed.ResultsMS showed higher frequency of perivenular lesions (median = 88%) than did inflammatory CNS vasculopathies (14%), without overlap between groups or differences between 3T and 1.5T MRI. Among inflammatory vasculopathies, Behçet disease showed the highest median frequency of perivenular lesions (34%), followed by PACNS (14%), antiphospholipid syndromes (12%), Sjögren syndrome (11%), and systemic lupus erythematosus (0%). When a threshold of 50% perivenular lesions was applied, central vein sign discriminated MS from inflammatory vasculopathies with a diagnostic accuracy of 100%.InterpretationThe central vein sign differentiates inflammatory CNS vasculopathies from MS at standard clinical magnetic field strengths. Ann Neurol 2018;83:283–294

show abstract

“…Of note, the 2010 revised criteria of McDonald (Polman et al., 2011) and MAGNISM criteria of 2016 (Filippi et al., 2016) define that a second attack can be diagnosed if there is a new T2 lesion or if there is new enhancing lesion.…”

Section: Introductionmentioning

confidence: 99%

MRI in predicting conversion to multiple sclerosis within 1 year

et al. 2018

View full text Add to dashboard Cite

ObjectivesMost patients diagnosed with multiple sclerosis (MS) present with a clinically isolated syndrome (CIS). We aimed to verify previously reported imaging and clinical findings, and to identify new MRI findings that might serve as prognostic factors for a second clinical episode or a change in the MRI scan during the first year following a CIS.Materials and MethodsWe identified from our medical records, 46 individuals who presented with an episode of CIS, which was followed clinically and with imaging studies. A neuroradiologist blinded to the clinical data reviewed the images and recorded the number of lesions, lesion location, and the largest longitudinal diameter of the lesion.ResultsOne year after the first MRI, 25 (54%) patients had progressed to MS. The clinical presentation of those who were and were not diagnosed with MS was predominantly motor or sensory deficit. Patients with lesions that were temporal, occipital, or perpendicular to the corpus callosum at the first episode were more likely to have recurrence. Individuals with a combination of more than 13 lesions, with maximal lesion length greater than 0.75 cm, and a lesion perpendicular to the corpus callosum, had a 19 times higher chance of conversion MS during the following year.ConclusionsAssessment of the number of lesions, lesion location, and maximal lesion size can predict the risk to develop another clinical episode or a new lesion/new enhancement in MRI during the year after CIS. For patients with a higher risk of recurrence, we recommend closer follow‐up.

show abstract

MRI criteria for the diagnosis of multiple sclerosis: MAGNIMS consensus guidelines

Cited by 698 publications

References 91 publications

Guidelines for the use of magnetic resonance imaging in diagnosing and monitoring the treatment of multiple sclerosis: recommendations of the Swedish Multiple Sclerosis Association and the Swedish Neuroradiological Society

Guidelines for the use of magnetic resonance imaging in diagnosing and monitoring the treatment of multiple sclerosis: recommendations of the Swedish Multiple Sclerosis Association and the Swedish Neuroradiological Society

Central vein sign differentiates Multiple Sclerosis from central nervous system inflammatory vasculopathies

MRI in predicting conversion to multiple sclerosis within 1 year

Contact Info

Product

Resources

About