MRI Contrast Agent-Based Multifunctional Materials: Diagnosis and Therapy

Yim, Hyeona; Seo, Seogjin; Na, Kun

doi:10.1155/2011/747196

Cited by 29 publications

(20 citation statements)

References 51 publications

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“…The sensitivity of a contrast agent is defined by its relaxivity parameters (longitudinal—r1 and transverse—r2). The development of high-relaxivity CAs is desirable because they provide contrast enhancement at lower doses compared to low-relaxivity compounds, therefore the potential toxic effects are reduced [ 101 , 102 , 103 ]. Nanocellulose in the form of cellulose nanocrystals was used in combination with ultra-small superparamagnetic iron oxide nanoparticles (USPIONs) to develop a novel T1-T2 contrast agent [ 104 ].…”

Section: Nanocellulose Hybrids With Magnetic Nanoparticlesmentioning

confidence: 99%

Nanocellulose Hybrids with Metal Oxides Nanoparticles for Biomedical Applications

Oprea

Panaitescu

2020

Molecules

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Cellulose is one of the most affordable, sustainable and renewable resources, and has attracted much attention especially in the form of nanocellulose. Bacterial cellulose, cellulose nanocrystals or nanofibers may serve as a polymer support to enhance the effectiveness of metal nanoparticles. The resultant hybrids are valuable materials for biomedical applications due to the novel optical, electronic, magnetic and antibacterial properties. In the present review, the preparation methods, properties and application of nanocellulose hybrids with different metal oxides nanoparticles such as zinc oxide, titanium dioxide, copper oxide, magnesium oxide or magnetite are thoroughly discussed. Nanocellulose-metal oxides antibacterial formulations are preferred to antibiotics due to the lack of microbial resistance, which is the main cause for the antibiotics failure to cure infections. Metal oxide nanoparticles may be separately synthesized and added to nanocellulose (ex situ processes) or they can be synthesized using nanocellulose as a template (in situ processes). In the latter case, the precursor is trapped inside the nanocellulose network and then reduced to the metal oxide. The influence of the synthesis methods and conditions on the thermal and mechanical properties, along with the bactericidal and cytotoxicity responses of nanocellulose-metal oxides hybrids were mainly analyzed in this review. The current status of research in the field and future perspectives were also signaled.

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Section: Nanocellulose Hybrids With Magnetic Nanoparticlesmentioning

confidence: 99%

Nanocellulose Hybrids with Metal Oxides Nanoparticles for Biomedical Applications

Oprea

Panaitescu

2020

Molecules

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“…This is achieved by the use of paramagnetic metal ions contrast agents which accelerates the T1 relaxation time and produce "bright" contrast in T1weighted images. Also, the super paramagnetic ion oxides (SPIOs) are used to increase T2 relaxation time to produce "dark" contrast on T2-weighted images [24].…”

Section: Ion Oxide Nanoparticlementioning

confidence: 99%

Integrating image fusion with nanoparticle contrast agents for diagnosis: a review

Manson

Hasford

Inkoom

et al. 2020

Egypt J Radiol Nucl Med

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Background As newer technologies in the field of medical imaging continue to expand, development of unique techniques for optimizing image quality and minimizing radiation dose becomes very necessary for improve diagnosis of pathologies and patient safety. Different types of medical imaging devices have been developed for specific diagnostic purposes. Main text This article provides a brief overview on the need for co-registration of some medical images into a single image (image fusion), advantages of some nanoparticle contrast agents in medical imaging, and a discussion of present and future role of integrating image fusion with nanoparticle contrast agents in diagnosis. Conclusion The use of nanoparticle contrast agents together with image fusion is a promising technique in future medical imaging as is likely to reveal pathologies of ≤ 1 nm sizes.

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“…Gold nanoparticles (AuNPs) are the most used ones, particulary gold nanorods (AuNRs) with their surface plasmonic resonance in the NIR frequency can act as efficient photothermal transducers. [48] Iron magnetic nanoparticles (MNPs) or magnetic nanobeads (MNBs) show photothermal transducer behavior under an alternating magnetic field and can also be easily functionalized. [49][50][51] Quantum dots (QDs) and Gadolinium (Gd) complexes are widely used for imaging purposes and are of great interest.…”

Section: Building Blocksmentioning

confidence: 99%

Thermoresponsive Nanodevices in Biomedical Applications

Bergueiro

Calderón

2014

Macromol. Biosci.

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In the last couple of decades several drug carriers have been tailored on the nanometric scale by taking advantage of new stimuli responsive materials. Thermoresponsive polymers in particular have been extensively employed as stimuli-responsive building blocks that in combination with other environmental-responsive materials allowed the birth of smarter systems that can respond to more than one stimulus. Examples that highlight the different polymers for thermally triggered drug delivery will be described. A special emphasis will be given to the description of novel theranostic nanodevices that combine more than one responsive modality in order to create a local hyperthermia that leads to the polymer phase transition and triggered drug release, cell recognition, and/or appearance of an imaging signal.

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MRI Contrast Agent-Based Multifunctional Materials: Diagnosis and Therapy

Cited by 29 publications

References 51 publications

Nanocellulose Hybrids with Metal Oxides Nanoparticles for Biomedical Applications

Nanocellulose Hybrids with Metal Oxides Nanoparticles for Biomedical Applications

Integrating image fusion with nanoparticle contrast agents for diagnosis: a review

Thermoresponsive Nanodevices in Biomedical Applications

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