MRI characterization of temporal lobe epilepsy using rapidly measurable spatial indices with hemisphere asymmetries and gender features

Datta, Siddhartha A.K.; Sarkar, Sudipta; Chakraborty, Sumit; Mulpuru, Sai Krishna; Basu, Suman; Tiwary, Basant K.; Chakrabarti, N.B.; Roy, Prasun K.

doi:10.1007/s00234-015-1540-6

Cited by 3 publications

(7 citation statements)

References 71 publications

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“…The inter-observer (radiologist vs. non-radiologist) variability (%) was non-significant (p>0.05, Student's unpaired t-test) for right and left hemispheric measurements of the data of healthy subjects (2.63±0.51 and 3.21±0.29 in men and 4.89±0.64 and 3.52±1.04 in women) by different observers for respective parameters. The inter-observer variability of the present study found to be consistent with our previous report (13).…”

Section: Status Of Brain Mri Parameterssupporting

confidence: 93%

“…For AV measurement, "the segmentation of amygdala in coronal slices started from the level of uncinate gyrus, continued over the temporal horn of the lateral ventricle, and the amygdala was separated from hippocampus at its narrowest point. More anteriorly, the gray-white boundary was used to separate amygdala from substantia innominata, inferior putamen and claustrum" (13).…”

Section: Measurements Of Hv and Avmentioning

confidence: 99%

“…The HA of both hemispheres was measured on the most rostral slice and delineated as "the angle between the horizontal line orthogonal to the falx cerebri and the uncal sulcus line between the deepest point of the uncal sulcus and the point nearest to the side of the ambient cistern in the uncal gyrus facing the uncal sulcus" (13). The MDR was measured as "the distance between the midline and the fimbria, normalized by dividing it into the distance from the midline to the peripheral margin of the temporal lobe", in the same or separate coronal sections with clear anatomical demarcations, in both hemispheres (13). The PHA was measured as the angle between descending and ascending portions of the PHG in both hemispheres individually in the same or separate coronal (occipital most) sections with clear anatomical demarcation.…”

Section: Measurements Of Ha Mdr and Phamentioning

confidence: 99%

“…The PHA was measured as the angle between descending and ascending portions of the PHG in both hemispheres individually in the same or separate coronal (occipital most) sections with clear anatomical demarcation. The MRI slice having fornix (presence of columns of fornix bellow corpus callosum) was used as the anatomical boundary of the posterior part of PHG for PHA measurements (13).…”

Section: Measurements Of Ha Mdr and Phamentioning

confidence: 99%

“…The AI was measured for both linear and non-linear MRI parameters following the standardized formula reported previously (13): "[2 X (Right hemispheric measure -Left hemispheric measure) / (Right hemispheric measure + Left hemispheric measure)]". The positive and negative signs of AI represent right (R) and left (L) hemispheric dominance respectively.…”

Section: Measurement Of Hemispheric Asymmetry Index(ai)mentioning

confidence: 99%

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Age and sex related variations of MRI parameters of hippocampus and amygdala in healthy humans: A cross sectional study using a small cohort

Datta¹,

Chakraborty²,

Sarkar³

et al. 2022

Biomedicine

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Introduction and Aim: Aging alters limbic structure, sex and hemispheric variations with anterior-posterior dominances of which are still obscure in relation to cognition in humans. Methodology: The present study included MRI coronal images for measurements of volumes [hippocampal volume (HV), amygdala volume (AV)], shapes [hippocampal angle (HA), medial distance ratio (MDR), parahippocampal angle (PHA)] and their hemispheric asymmetry indices (AI) in male and female healthy individuals of young and aged groups. The best-fitted formulae of 'volume index' (VI) and 'shape index' (SI) were evaluated for better interpretation. Results: In young, males showed larger bi-hemispheric volumes and AV/HV-ratios, greater HA and MDR values with distinct hemispheric dominances and greater VI with different SI values, compared to females. Aged subjects showed lesser VI and bi-hemispheric volumes compared to young counterparts where the decrement of volumes were more in aged males resulting in same volumes and AV/HV-ratios in both aged sexes. Only aged females exhibited greater HA and MDR values with altered SI compared to young counterparts retaining the sex-specific such differences with their altered AIs. The parametric changes showed significant correlations in respective cases. PHA remained unaltered in all cases. Conclusion: Sex-specific volume differences in young and volume reduction in age might associate with distinct alterations of hippocampal shapes viz. shifting of the (a) head (anterior portion) vertically compared to its horizontal position and (b) body (posterior portion) laterally toward temporal cortex, in both hemispheres. The recent findings claim further studies to unveil the cognitive variations corroborated with such limbic structural/shape alterations among sexes and ages.

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Section: Status Of Brain Mri Parameterssupporting

confidence: 93%

Section: Measurements Of Hv and Avmentioning

confidence: 99%

Section: Measurements Of Ha Mdr and Phamentioning

confidence: 99%

Section: Measurements Of Ha Mdr and Phamentioning

confidence: 99%

Section: Measurement Of Hemispheric Asymmetry Index(ai)mentioning

confidence: 99%

See 3 more Smart Citations

Age and sex related variations of MRI parameters of hippocampus and amygdala in healthy humans: A cross sectional study using a small cohort

Datta¹,

Chakraborty²,

Sarkar³

et al. 2022

Biomedicine

View full text Add to dashboard Cite

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Therapeutic Platforms for Ischemic and Traumatic Brain Injuries Across National-Level Neuroimaging Grids

Roy

Kapoor

Pareek

et al. 2016

Healthcare Engineering

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Applications of global quantitative18F-FDG-PET analysis in temporal lobe epilepsy

Peter

Houshmand

Werner

et al. 2016

Nuclear Medicine Communications

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Temporal lobe epilepsy (TLE) is a prevalent neurodegenerative disease associated with various neuropsychiatric disorders and decreased quality of life. Much has been said about the use of fluorine-18 fluorodeoxyglucose positron emission tomography (18F-FDG-PET), magnetic resonance imaging (MRI), and computed tomography in the qualitative assessment of TLE. However, research into the applications of quantitative measurements to treat and diagnose TLE is severely lacking in the literature. Global quantitative analysis using 18F-FDG-PET is a powerful tool in the metabolic assessment of TLE, and can more accurately identify seizure lateralization and the potential effects of treatment as compared with visual assessments and traditional biopsy region-of-interest quantification. Therefore, there is a pressing need to introduce these novel methods to the treatment of TLE. Although 18F-FDG-PET is most commonly used for visual assessments, qualitative analysis is associated with high levels of interobserver and intraobserver variability. Semiquantitative analysis using standardized uptake value is a more consistently accurate measure of the hypometabolic patterns seen in TLE patients. Novel methods of global quantitative analysis developed in our laboratory have the potential to improve TLE assessment by limiting variability and correcting for the partial volume effect. It is of great importance to adopt these techniques into the mainstream diagnosis and treatment of TLE in order to improve patient care worldwide.

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MRI characterization of temporal lobe epilepsy using rapidly measurable spatial indices with hemisphere asymmetries and gender features

Cited by 3 publications

References 71 publications

Age and sex related variations of MRI parameters of hippocampus and amygdala in healthy humans: A cross sectional study using a small cohort

Age and sex related variations of MRI parameters of hippocampus and amygdala in healthy humans: A cross sectional study using a small cohort

Therapeutic Platforms for Ischemic and Traumatic Brain Injuries Across National-Level Neuroimaging Grids

Applications of global quantitative18F-FDG-PET analysis in temporal lobe epilepsy

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