MRI-based vertebral bone quality score compared to quantitative computed tomography bone mineral density in patients undergoing cervical spinal surgery

Oezel, Lisa; Okano, Ichiro; Jones, Conor; Salzmann, Stephan N.; Shue, Jennifer; Amini, Dominik Adl; Moser, Manuel; Chiapparelli, Erika; Sama, Andrew A.; Carrino, John A.; Cammisa, Frank P.; Girardi, Federico P.; Hughes, Alexander P.

doi:10.1007/s00586-023-07570-2

Cited by 9 publications

(4 citation statements)

References 47 publications

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“…The results of www.nature.com/scientificreports/ our study showed significantly differences in VBQ score between BMD subgroups. The patients with low BMD had a higher VBQ score, which was consistent with previous studies [26][27][28][29] . VBQ score had a moderate to strong negative linear correlation with QCT-based BMD.…”

Section: Discussionsupporting

confidence: 91%

MRI-based vertebral bone quality score as a novel bone status marker of patients with adolescent idiopathic scoliosis

Yang,

Li,

Tian

et al. 2024

Sci Rep

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To investigate the application of MRI-based vertebral bone quality (VBQ) score in assessing bone mineral density (BMD) for patients with adolescent idiopathic scoliosis (AIS). We reviewed the data of AIS patients between January 2021 and October 2023 with MRI, whole-spine plain radiographs, quantitative computed tomography (QCT) and general information. VBQ score was calculated using T1-weighted MRI. Univariate analysis was applied to present the differences between variables of patients with normal BMD group (QCT Z-score > − 2.0) and low BMD group (QCT Z-score ≤ − 2.0). The correlation between VBQ score and QCT Z-score was analyzed with Pearson correlation test. A multivariate logistic regression model was used to determine the independent factors related to low BMD. Receiver operating characteristic curve (ROC) was drawn to analyze the diagnostic performance of VBQ score in distinguishing low BMD. A total of 136 AIS patients (mean age was 14.84 ± 2.10 years) were included, of which 41 had low BMD. The low BMD group had a significantly higher VBQ score than that in normal group (3.48 ± 0.85 vs. 2.62 ± 0.62, P < 0.001). The VBQ score was significantly negative correlated with QCT Z score (r = − 0.454, P < 0.001). On multivariate analysis, VBQ score was independently associated with low BMD (OR: 4.134, 95% CI 2.136–8.000, P < 0.001). The area under the ROC curve indicated that the diagnostic accuracy of the VBQ score for predicting low BMD was 81%. A sensitivity of 65.9% with a specificity of 88.4% could be achieved for distinguishing low BMD by setting the VBQ score cutoff as 3.18. The novel VBQ score was a promising tool in distinguishing low BMD in patients with AIS and could be useful as opportunistic assessment for screening and complementary evaluation to QCT before surgery.

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Section: Discussionsupporting

confidence: 91%

MRI-based vertebral bone quality score as a novel bone status marker of patients with adolescent idiopathic scoliosis

Yang,

Li,

Tian

et al. 2024

Sci Rep

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“…The results of our study showed signi cantly differences in VBQ score between BMD subgroups. The low-BMD group had a higher VBQ score, which was consistent with previous studies [24,25]. VBQ score had a moderate negative linear correlation with QCT Z score.…”

Section: Discussionsupporting

confidence: 91%

MRI-based vertebral bone quality score as a novel bone status marker of patients with adolescent idiopathic scoliosis

Yang,

Li,

Tian

et al. 2024

Preprint

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Purpose: To evaluate the application of MRI-based L1-L4 vertebral bone quality (VBQ) score in assessing bone mineral density (BMD) for patients with adolescent idiopathic scoliosis (AIS). Methods: We reviewed the data of AIS patients between January 2021 and October 2023 with MRI, whole-spine plain radiographs, quantitative computed tomography (QCT) and general information. VBQ L1-L4 score was calculated using T1-weighted MRI. Univariate analysis was applied to present the differences between variables of patients with normal group (Z-score>-2.0) and low-BMD group (Z-score≤-2.0). The correlation between the VBQ score and QCT Z-score was analyzed with Pearson correlation test. A multivariate logistic regression model was used to determine the independent factors related to low BMD. Receiver operating characteristic curve (ROC) was drawn to analyze the diagnostic performance of VBQ L1-L4 score in distinguishing low BMD. Results: A total of 136 AIS patients (mean age was 14.84±2.10 years) were included, of which 41 had low BMD. The low-BMD group had a significantly higher VBQL1-L4 score than that in normal group (3.48±0.85 vs 2.62±0.62, P< 0.001). The VBQL1-L4 score was significantly negative correlated with QCT Z score (r = − 0.454, P< 0.001). On multivariate analysis, VBQL1-L4 score was independently associated with low BMD (OR: 4.134, 95% CI: 2.136–8.000, P<0.001). The area under the ROC curve indicated that the diagnostic accuracy of the VBQL1-L4 score for predicting low BMD was 81%. A sensitivity of 65.9% with a specificity of 88.4% could be achieved for distinguishing low BMD by setting the VBQL1-L4 score cutoff as 3.18. Conclusions: The novel VBQL1-L4 score was a promising tool in distinguishing low BMD in patients with AIS and could be useful as opportunistic assessment for screening and complementary evaluation to QCT before surgery.

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“…Since inception, the C-VBQ and VBQ scores have been demonstrated to significantly correlate with both CT Hounsfield units and DEXA values, potentially joining these bone quality evaluative tools. 27,28 All these led to the idea of this project because DJK has the same mechanism as proximal junctional kyphosis but was applied to the inferior vertebral body instead of a vertebral body located superiorly to the fused segment of thoracolumbar fusions. In this study, the univariate analysis demonstrated a significantly higher C-VBQ score in the DJK group than in the non-DJK group (2.97 ± 0.40 vs 2.26 ± 0.46) (P < .001).…”

Section: Development and Application Of C-vbqmentioning

confidence: 99%

Cervical Vertebral Bone Quality Score Independently Predicts Distal Junctional Kyphosis After Posterior Cervical Fusion

Aguirre,

Soliman,

Kuo

et al. 2023

Neurosurgery

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BACKGROUND AND OBJECTIVE: Posterior cervical fusion is the surgery of choice when fusing long segments of the cervical spine. However, because of the limited presence of this pathology, there is a paucity of data in the literature about the postoperative complications of distal junctional kyphosis (DJK). We aimed to identify and report potential associations between the preoperative cervical vertebral bone quality (C-VBQ) score and the occurrence of DJK after posterior cervical fusion. METHODS: The authors retrospectively reviewed records of patients who underwent posterior cervical fusion at a single hospital between June 1, 2010, and May 31, 2020. Patient data were screened to include patients who were >18 years old, had baseline MRI, had baseline standing cervical X-ray, had immediate postoperative standing cervical X-ray, and had clinical and radiographic follow-ups of >1 year, including a standing cervical X-ray at least 1 year postoperatively. Univariate analysis was completed between DJK and non-DJK groups, with multivariate regression completed for relevant clinical variables. Simple linear regression was completed to analyze correlation between the C-VBQ score and total degrees of kyphosis angle change. RESULTS: Ninety-three patients were identified, of whom 19 (20.4%) had DJK and 74 (79.6%) did not. The DJK group had a significantly higher C-VBQ score than the non-DJK group (2.97 ± 0.40 vs 2.26 ± 0.46; P < .001). A significant, positive correlation was found between the C-VBQ score and the total degrees of kyphosis angle change (r2 = 0.26; P < .001). On multivariate analysis, the C-VBQ score independently predicted DJK (odds ratio, 1.46; 95% CI, 1.27-1.67; P < .001). CONCLUSION: We found that the C-VBQ score was an independent predictive factor of DJK after posterior cervical fusion.

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MRI-based vertebral bone quality score compared to quantitative computed tomography bone mineral density in patients undergoing cervical spinal surgery

Cited by 9 publications

References 47 publications

MRI-based vertebral bone quality score as a novel bone status marker of patients with adolescent idiopathic scoliosis

MRI-based vertebral bone quality score as a novel bone status marker of patients with adolescent idiopathic scoliosis

MRI-based vertebral bone quality score as a novel bone status marker of patients with adolescent idiopathic scoliosis

Cervical Vertebral Bone Quality Score Independently Predicts Distal Junctional Kyphosis After Posterior Cervical Fusion

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