MRI-based quantitative assessment of the hippocampal region in very mild to moderate Alzheimer's disease

Ikeda, Manabu; Tanabe, Hirotaka; Nakagawa, Yoshitsugu; Kazui, Hiroaki; Oi, H.; Yamazaki, Hideki; Harada, Kazuhiro; Nishimura, Tsuyoshi

doi:10.1007/bf00599184

Cited by 60 publications

(27 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This condition may explain the finding that AD duration was not related to HPC atrophy, supporting the evidence of HPC atrophy in the early stages of AD [17,19,50,62].…”

Section: Commentsupporting

confidence: 65%

See 1 more Smart Citation

Hippocampus and Parahippocampal Gyrus Linear Measurements Based on Magnetic Resonance in Alzheimer’s Disease

Pucci

Belardinelli²,

Regnicolo³

et al. 1998

Eur Neurol

View full text Add to dashboard Cite

MRI-based linear measurements of the hippocampus and parahippocampal gyrus complex (HPC) discriminated 39 subjects with probable Alzheimer’s disease, from 15 patients with other dementias and 33 miscellaneous controls without evidence of dementia. The best discriminating parameter was the left height of the HPC at the level of the mammillary bodies, with a sensitivity of 79.49% and a specificity of 68.75%. The diagnostic value of these results is discussed considering the volumetric data found in the current literature.

show abstract

“…This condition may explain the finding that AD duration was not related to HPC atrophy, supporting the evidence of HPC atrophy in the early stages of AD [17,19,50,62].…”

Section: Commentsupporting

confidence: 65%

“…Eur Neurol 1998;39: [16][17][18][19][20][21][22][23][24][25] Pucci/Belardinelli/Regnicolo/Nolfe/ Signorino/Salvolini/Angeleri OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO…”

Section: Acknowledgmentsmentioning

confidence: 99%

Hippocampus and Parahippocampal Gyrus Linear Measurements Based on Magnetic Resonance in Alzheimer’s Disease

Pucci

Belardinelli²,

Regnicolo³

et al. 1998

Eur Neurol

View full text Add to dashboard Cite

show abstract

“…Although we had a small sample of mild AD patients, we also examined whether there were any differences in overall vigilance or vigilance decrement or both in possible versus probable AD patients, relative to each other and to control participants. Although possible and probable AD usually reflect different degrees of diagnostic certainty, some studies suggest that they may also reflect differing degrees of AD severity, with possible AD patients being less impaired than probable AD patients (e.g., Hughes, Perkins, Wright, & Westrick, 2003;Ikeda et al, 1994;Perry, Watson, & Hodges, 2000). …”

mentioning

confidence: 99%

Sustained Attention in Mild Alzheimer's Disease

Berardi¹,

Parasuraman²,

Haxby³

2005

Developmental Neuropsychology

View full text Add to dashboard Cite

The vigilance decrement in perceptual sensitivity was examined in 10 patients with mild Alzheimer's disease (AD) and 20 age-matched controls. A visual high-event rate digit-discrimination task lasting 7.2 min. (six 1.2 min blocks) was presented at different levels of stimulus degradation. Previous studies have shown that sensitivity decrements (d′) over time at high-stimulus degradation result from demands on effortful processing. For all degradation levels, the overall level of vigilance (d′) was lower in AD patients than in controls. All participants showed sensitivity decrement over blocks, with greater decrement at higher degradation levels. AD patients exhibited greater sensitivity decrement over time at the highest degradation level they all could perform relative to control participants. There were no concomitant changes in either response bias (C) or response times. The results indicate that mild AD patients have overall lower levels of vigilance under conditions that require both automatic and effortful processing. Mild AD patients also exhibit a deficit in the maintenance of vigilance over time under effortful processing conditions. Although the sample of AD patients was small, results further suggest that both possible and probable AD patients had greater sensitivity decrement over time at the highest degradation level than did control participants, but only probable AD patients had lower overall levels of vigilance. In the possible AD patients as a group, the decrement in vigilance occurred in the absence of concurrent deficits on standard attentional tasks, such as the Stroop and Trail Making tests, suggesting that deficits in vigilance over time may appear earlier than deficits in selective attention.Alzheimer's disease (AD) is a progressive, degenerative brain disorder, the most usual and early clinical manifestation of which is memory impairment (Baddeley, Della Sala, Logie, & Spinnler, 1986;Morris & Kopelman, 1986). Attentional functions, particularly selective and divided attention, are also affected early in the course of AD (Parasuraman & Haxby, 1993). Although sustained attention has been less extensively studied, this aspect of attention is worthy of further investigation in relation to dementia, for several reasons. First, clinical observations indicate that demented patients have difficulty concentrating and fatigue easily (Lezak, 1995). Altered sustained attention in AD patients may also contribute to their deficits in other cognitive functions. Furthermore, everyday activities such as safe driving (Ball, 1997;Duchek, Hunt, Ball, Buckles, & Morris, 1997Hunt, Morris, Edwards, & Wilson, 1993; and prevention of falls (Buchner & Larson, 1987) may depend on intact maintenance of attention.Several different experimental paradigms have been used to investigate sustained attention, including signal detection (Bushnell & Rice, 1999), serial reaction (Robbins, 1998), responseRequests for reprints should be sent to Anna Maria Berardi, Department of Psychology, University of Metz, Ile du Sau...

show abstract

“…They have uniformly reported significant and striking differences between MRI measures of the medial temporal lobe in AD patients and controls. Measures of the hippocampal formation, the parahippocampal gyrus, the amygdalohippocampal complex, and the temporal horn of the lateral ventricles have demonstrated significant differences between mildly impaired AD patients and controls across a wide range of studies, using a variety of techniques (28)(29)(30)(31)(32)(33)(34)(35). These studies are consistent with computerized tomography (CT) studies showing suprasellar cistern͞temporal horn abnormalities in AD (e.g., refs.…”

Section: Changes In Brain Structure In Early Admentioning

confidence: 99%

Cognitive and neurobiologic markers of early Alzheimer disease

Albert

1996

Proc. Natl. Acad. Sci. U.S.A.

221

117

View full text Add to dashboard Cite

Recent studies indicate that impairments in two cognitive domains characterize the cognitive abnormalities that appear earliest in the course of Alzheimer disease (AD). These cognitive domains pertain to memory and executive function ability; in particular, memory test scores ref lecting the difference between immediate and delayed recall and tasks that assess cognitive f lexibility (e.g., set-shifting). Preliminary data indicate that tasks of this nature, along with specific genetic information (i.e., APOE-4 status), are important in identifying which individuals with recent cognitive changes (considered to have ''questionable'' disease) will progress to the point where they meet criteria for AD over time. When this cognitive and genetic information is combined with neuroimaging measures targeted at the brain regions demonstrating pathology early in AD, it may serve as specific and accurate prognostic markers of AD.Memory changes are generally the earliest cognitive change seen in Alzheimer disease (AD). Changes in executive function ability (which include the abilities responsible for concurrent manipulation of information, concept formation, and goaldirected behavior) also show significant declines early in the course of AD. A variety of neurobiologic measures can be found that reflect these alterations in cognitive function. This paper will review the early cognitive changes associated with AD, their neurobiologic correlates, and present preliminary data concerning predictors of the development of AD in individuals who have changes in memory that suggest they may be developing AD. Memory Changes in Early ADDifficulty with the acquisition of new information is generally the first and most salient symptom to emerge in patients with AD. When clinical neuropsychological tests are used to evaluate memory in AD patients, it is clear that recall and recognition performance are impaired in both the verbal and nonverbal domain (1, 2).Experimental studies have examined AD patients to determine whether the manner in which information is lost over brief delays is unique in any way to this patient group. The results of these studies suggest that a comparison of immediate and delayed recall performance may be a useful diagnostic measure for identifying patients with AD.

show abstract

MRI-based quantitative assessment of the hippocampal region in very mild to moderate Alzheimer's disease

Cited by 60 publications

References 18 publications

Hippocampus and Parahippocampal Gyrus Linear Measurements Based on Magnetic Resonance in Alzheimer’s Disease

Hippocampus and Parahippocampal Gyrus Linear Measurements Based on Magnetic Resonance in Alzheimer’s Disease

Sustained Attention in Mild Alzheimer's Disease

Cognitive and neurobiologic markers of early Alzheimer disease

Contact Info

Product

Resources

About