MRI-based quantification of renal perfusion in mice: Improving sensitivity and stability in FAIR ASL

Gutjahr, Fabian Tobias; Günster, Stephan Michael; Kampf, Thomas; Winter, Patrick; Herold, Volker; Bauer, Wolfgang R.; Jakob, Peter M.

doi:10.1016/j.zemedi.2017.02.001

Cited by 5 publications

(2 citation statements)

References 15 publications

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“…Several MR‐based methods have been used to study renal physiology with the purpose of finding biomarkers that reflect early changes in kidney diseases. Notable examples include dynamic contrast‐enhanced MRI (DCE‐MRI) and arterial spin labeling (ASL) …”

Section: Introductionmentioning

confidence: 99%

“…Notable examples include dynamic contrast-enhanced MRI (DCE-MRI) 4,5 and arterial spin labeling (ASL). 6,7 DCE-MRI allows for the measurement of perfusion and filtration, both of which are key parameters in the assessment of renal function. DCE-MRI, however, is an invasive technique that requires an injection of gadolinium as a contrast agent.…”

Section: Introductionmentioning

confidence: 99%

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Dissolved hyperpolarized xenon‐129 MRI in human kidneys

Chacon‐Caldera

Maunder

Rao

et al. 2019

Magnetic Resonance in Med

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Purpose To assess the feasibility of using dissolved hyperpolarized xenon‐129 (129Xe) MRI to study renal physiology in humans at 3 T. Methods Using a flexible transceiver RF coil, dynamic and spatially resolved 129Xe spectroscopy was performed in the abdomen after inhalation of hyperpolarized 129Xe gas with 3 healthy male volunteers. A transmit‐only receive‐only RF coil array was purpose‐built to focus RF excitation and enhance sensitivity for dynamic imaging of 129Xe uptake in the kidneys using spoiled gradient echo and balanced steady‐state sequences. Results Using spatially resolved spectroscopy, different magnitudes of signal from 129Xe dissolved in red blood cells and tissue/plasma could be identified in the kidneys and the aorta. The spectra from both kidneys showed peaks with similar amplitudes and chemical shift values. Imaging with the purpose‐built coil array was shown to provide more than a 3‐fold higher SNR in the kidneys when compared with surrounding tissues, while further physiological information from the dissolved 129Xe in the lungs and in transit to the kidneys was provided with the transceiver coil. The signal of dissolved hyperpolarized 129Xe could be imaged with both tested sequences for about 40 seconds after inhalation. Conclusion The uptake of 129Xe dissolved in the human kidneys was measured with spectroscopic and imaging experiments, demonstrating the potential of hyperpolarized 129Xe MR as a novel, noninvasive technique to image human kidney tissue perfusion.

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Section: Introductionmentioning

confidence: 99%