MRI-based estimation of liver function by intravoxel incoherent motion diffusion-weighted imaging

Zhang, Jing; Guo, Yihao; Tan, Xiangliang; Zheng, Zeyu; He, Mengqi; Xu, Jun; Mei, Yingjie; Zhang, Jiajun; Zhao, Xixi; Wang, Chunhong; Feng, Yanqiu; Chan, Queenie; Wu, Yuankui; Xu, Yu

doi:10.1016/j.mri.2016.05.013

Cited by 18 publications

(19 citation statements)

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“…Various fitting algorithms have been used to determine IVIM parameters, including asymptotic fitting (9)(10)(11)(12)(19)(20)(21)24,41,45,46,48,51,53), nonlinear least square (usually Levenberg-Marquardt) fitting (23,42,47,52,54,55), and Bayesian fitting (15,22,40,43,50). Current review cannot draw conclusion which one is better than others, nor can the mean values be compared (Figure 8).…”

Section: Image Post-processing Methods For Ivim Parametersmentioning

confidence: 99%

“…Accumulation of collagen deposits and activated stellate cells contribute to increased hepatic resistance to portal blood flow, development of portal hypertension, and reduced portal blood perfusion. The decrease of blood perfusion can arise from a number of concomitant alterations in the tissue microenvironment, including collagen deposition, fatty (9)(10)(11)15,23,24,42,43,45,46,(48)(49)(50)(51)(53)(54)(55), free-breathing (FB) (19)(20)(21)40,41,47), and breath-hold (BH) (44). Solid line represents the median value of each group.…”

Section: Ivim For Liver Fibrosis Evaluationmentioning

confidence: 99%

See 1 more Smart Citation

Liver intravoxel incoherent motion (IVIM) magnetic resonance imaging: a comprehensive review of published data on normal values and applications for fibrosis and tumor evaluation

Lǐ¹,

Cercueil²,

Yuan³

et al. 2017

Quant. Imaging Med. Surg.

123

210

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Section: Image Post-processing Methods For Ivim Parametersmentioning

confidence: 99%

Section: Ivim For Liver Fibrosis Evaluationmentioning

confidence: 99%

Liver intravoxel incoherent motion (IVIM) magnetic resonance imaging: a comprehensive review of published data on normal values and applications for fibrosis and tumor evaluation

Lǐ¹,

Cercueil²,

Yuan³

et al. 2017

Quant. Imaging Med. Surg.

123

210

View full text Add to dashboard Cite

“…22 A decreased D value in chronic liver disease reflects an increase in connective tissue, which changes the cell density and histological structure. 19 D* and f values are surrogate markers of capillary liver perfusion. 10 A decreased D* or f value reflects decreased capillary perfusion.…”

Section: Discussionmentioning

confidence: 99%

“…5,6,10 A decreased D value in chronic liver disease reflects an increase in connective tissue, which changes the cell density and histological structure. 19 D* is the pseudo-diffusion coefficient representing the capillary perfusion within the voxel, and f is the perfusion fraction related to the capillary perfusion. Both D* and f values are surrogate markers of capillary liver perfusion, 10 and a decreased D* or f value reflects decreased capillary perfusion.…”

Section: Liver Intravoxel Incoherent Motion Imaging and Analysismentioning

confidence: 99%

“…Intravoxel incoherent motion imaging has been successfully applied to the assessment of liver fibrosis and cirrhosis in adult patients with normal heart structure. 10,[16][17][18][19][20] Intravoxel incoherent motion imaging may be a potential tool for detecting liver abnormalities without being affected by central venous pressure in patients with Fontan circulation.…”

Section: Introductionmentioning

confidence: 99%

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Intravoxel incoherent motion imaging has the possibility to detect liver abnormalities in young Fontan patients with good hemodynamics

et al. 2019

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Introduction:Liver fibrosis and cirrhosis are one of the critical complications in Fontan patients. However, there are no well-established non-invasive and quantitative techniques for evaluating liver abnormalities in Fontan patients. Intravoxel incoherent motion diffusion-weighted imaging with MRI is a non-invasive and quantitative method to evaluate capillary network perfusion and molecular diffusion. The objective of this study is to assess the feasibility of intravoxel incoherent motion imaging in evaluating liver abnormalities in Fontan children.Materials and Methods:Five consecutive Fontan patients and four age-matched healthy volunteers were included. Fontan patients were 12.8 ± 1.5 years old at the time of MRI scan. Intravoxel incoherent motion imaging parameters (D, D*, and f values) within the right hepatic lobe were compared. Laboratory test, ultrasonography, and cardiac MRI were also conducted in the Fontan patients. Results of cardiac catheterization conducted within one year of the intravoxel incoherent motion imaging were also examined.Results:In Fontan patients, laboratory test and liver ultrasonography showed almost normal liver condition. Cardiac catheter and MRI showed good Fontan circulation. Cardiac index was 2.61 ± 0.23 L/min/m2. Intravoxel incoherent motion imaging parameters D, D*, and f values were lower in Fontan patients compared with controls (D: 1.1 ± 0.0 versus 1.3 ± 0.2 × 10−3 mm2/second (p = 0.04), D*: 30.8 ± 24.8 versus 113.2 ± 25.6 × 10−3 mm2/second (p < 0.01), and f: 13.2 ± 3.1 versus 22.4 ± 2.4% (p < 0.01), respectively).Conclusions:Intravoxel incoherent motion imaging is feasible for evaluating liver abnormalities in children with Fontan circulation.

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Multiparametric MRI Evaluation of Liposomal Prostaglandins E1 Intervention on Hepatic Warm Ischemia‐Reperfusion Injury in Rabbits

Jiang

Chu

et al. 2019

Magnetic Resonance Imaging

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BackgroundLiposomal prostaglandin E1 (Lipo‐PGE1) treatment should protect against hepatic warm ischemia‐reperfusion injury (WIRI). Improved methods are needed for the noninvasive evaluation of hepatic responses to prophylactic Lipo‐PGE1 pretreatment approaches.PurposeTo demonstrate that multiparametric MRI measurements permit noninvasive differentiation of Lipo‐PGE1 treatment outcomes in a hepatic WIRI animal model.Study TypeAnimal study.Animal ModelSeventy rabbits were randomly divided into a sham‐operated group (A0), warm ischemia groups experiencing increasing periods of ischemia (A1–A3), and corresponding intervention groups (I1–I3) (n = 10 for each group).Field Strength/SequenceImaging was performed at 3T using a multiecho gradient echo (GRE) sequence (repetition time / echo time [TR/TE], 75/2.57–24.25 msec) for R2* blood oxygenation level‐dependent (BOLD) measurements, free‐breathing single‐shot echo‐planar imaging (ss‐EPI) sequence with two b‐values (0 and 500 s/mm2) in 12 diffusion directions for diffusion tensor imaging (DTI), and a free‐breathing ss‐EPI sequence with eight b‐values (0 to 800 s/mm2) for intravoxel incoherent motion (IVIM) measurements.AssessmentThe BOLD‐derived parameter (R2*), DTI‐derived parameters (ADC, FA), and IVIM‐derived parameters (Dslow, Dfast, and PF) were calculated for comparisons between treatment groups and correlation to ALT, AST, and LDH levels.Statistical TestsOne‐way analysis of variance (ANOVA), independent sample t‐test, Spearman correlation, and receiver operating characteristic (ROC) analysis were performed.ResultsHistopathology confirmed the validity of the WIRI model and the efficacy of intervention with clear structure and morphology differences between the different ischemia times and between the Lipo‐PGE1 treatment and control groups. Prolonged warm ischemia times resulted in higher R2* and FA values and gradually lower ADC, Dslow, Dfast, and PF values (all P < 0.05). The R2* and FA values were lower, and the ADC, Dslow, Dfast, and PF values were higher in the Lipo‐PGE1 intervention groups compared with those in the warm ischemia group for each paired time. However, none of the parameters reached the levels of the A0 group (all P < 0.05). As the warm ischemia time increased, additional parameters demonstrated significant differences between warm ischemia time groups and corresponding intervention groups. At the shortest (30 min), middle (40 min), and longest (60 min) ischemia times, three, four, and five parameters were significantly different between the WIRI and intervention groups, respectively (all P < 0.05). ADC, Dslow, Dfast, and PF values were negatively correlated, while R2* and FA values were positively correlated with serum ALT (|r| = 0.312–0.606) and AST (|r| = 0.432–0.602) (all P < 0.05). ADC and Dfast values showed negative correlations, and R2* showed positive correlations with serum LDH (|r| = 0.323–0.542, all P < 0.05). ROC analysis showed that DTI yielded the strongest diagnostic performance for evaluating the improvement of WIRI.Data ConclusionMultiparametric MRI can serve as a noninvasive radiologic evaluation for monitoring the protective impact of Lipo‐PGE1 therapy on hepatic WIRI.Level of Evidence: 1Technical Efficacy Stage: 2J. Magn. Reson. Imaging 2020;52:217–228.

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MRI-based estimation of liver function by intravoxel incoherent motion diffusion-weighted imaging

Cited by 18 publications

References 29 publications

Liver intravoxel incoherent motion (IVIM) magnetic resonance imaging: a comprehensive review of published data on normal values and applications for fibrosis and tumor evaluation

Liver intravoxel incoherent motion (IVIM) magnetic resonance imaging: a comprehensive review of published data on normal values and applications for fibrosis and tumor evaluation

Intravoxel incoherent motion imaging has the possibility to detect liver abnormalities in young Fontan patients with good hemodynamics

Multiparametric MRI Evaluation of Liposomal Prostaglandins E1 Intervention on Hepatic Warm Ischemia‐Reperfusion Injury in Rabbits

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