MRI assessment of cerebral perfusion in clinical trials

Wang, Xue; Bishop, Courtney; O’Callaghan, James M.; Gayhoor, Ali; Albani, Justin M.; Theriault, Wendy; Chappell, Michael A.; Golay, Xavier; Wang, Danny; Becerra, Lino

doi:10.1016/j.drudis.2023.103506

Cited by 9 publications

(4 citation statements)

References 75 publications

(98 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the experiment, all the samples were injected into the tumor-bearing mice, respectively, followed by imaging detection. The clinical value of MRI lies in its ability to deliver detailed soft tissue information, and the contrast agent could further enhance its detection sensitivity [ 42 ]. Herein, the T 2 signal intensity in the tumor areas was significantly decreased after 24 h of IR780@BSA@SPIO injection, compared to the signal before injection and the PBS group, which was markedly distinct from normal tissues, as demonstrated in Figure 4A and Supplementary Figure S8 ; and the fluorescence intensity of the tumor areas increased over time ( Figure 4B and C ), suggesting that the nanosystem was accumulating in the tumor areas.…”

Section: Resultsmentioning

confidence: 99%

Albumin-based nanosystem for dual-modality imaging-guided chem-phototherapy against immune-cold triple-negative breast cancer

Peng,

Zeng,

Cai

et al. 2023

Regenerative Biomaterials

View full text Add to dashboard Cite

Triple-negative breast cancer is a highly aggressive and metastatic tumor; diagnosing it in the early stages is still difficult, and the prognosis for conventional radio-chemotherapy and immunotreatment is not promising due to cancer’s immunosuppressive microenvironment. The utilization of protein-based nanosystem has proven to be effective in delivering agents with limited adverse effects, yet the combination of diagnosis and treatment remains a difficult challenge. This research took advantage of natural albumin and organic molecules to construct a self-assemble core-shell nanostructure combining with superparamagnetic iron oxide nanocrystals and heptamethine cyanine dye IR780 through non-covalent interactions. This nanocomposite successfully decreased the transverse relaxation time of the magnetic resonance hydrogen nucleus, resulting in outstanding T2 imaging, as well as emitting near-infrared II fluorescence, thereby the resulting dual-modality imaging tool was applied to improve diagnostic competency. It is noteworthy that the nanocomposites exhibited impressive enzyme-like catalytic and photothermal capabilities, resulting in a successful activation of the immune system to efficiently suppress distant metastatic lesions in vivo. Consequently, this nanodrug-based therapy could be an advantageous asset in reinforcing the immune system and hindering the growth and reappearance of the immune-cold breast cancer.

show abstract

Section: Resultsmentioning

confidence: 99%

Albumin-based nanosystem for dual-modality imaging-guided chem-phototherapy against immune-cold triple-negative breast cancer

Peng,

Zeng,

Cai

et al. 2023

Regenerative Biomaterials

View full text Add to dashboard Cite

show abstract

“…Also, this inventory is aimed uniquely at pipeline selection and does not provide details or guidance for performing ASL processing. However, literature is available for ASL beginners for designing studies, 35 acquisition protocol, 14 quantification, 36 processing, 17 and clinical use 37 . Most of the pipelines, however, handle raw data and provide CBF in different regions of interest, which can be used for statistical analysis.…”

Section: Discussionmentioning

confidence: 99%

ISMRM Open Science Initiative for Perfusion Imaging (OSIPI): ASL pipeline inventory

Fan,

Mutsaerts,

Anazodo

et al. 2023

Magnetic Resonance in Med

View full text Add to dashboard Cite

PurposeTo create an inventory of image processing pipelines of arterial spin labeling (ASL) and list their main features, and to evaluate the capability, flexibility, and ease of use of publicly available pipelines to guide novice ASL users in selecting their optimal pipeline.MethodsDevelopers self‐assessed their pipelines using a questionnaire developed by the Task Force 1.1 of the ISMRM Open Science Initiative for Perfusion Imaging. Additionally, each publicly available pipeline was evaluated by two independent testers with basic ASL experience using a scoring system created for this purpose.ResultsThe developers of 21 pipelines filled the questionnaire. Most pipelines are free for noncommercial use (n = 18) and work with the standard NIfTI (Neuroimaging Informatics Technology Initiative) data format (n = 15). All pipelines can process standard 3D single postlabeling delay pseudo‐continuous ASL images and primarily differ in their support of advanced sequences and features. The publicly available pipelines (n = 9) were included in the independent testing, all of them being free for noncommercial use. The pipelines, in general, provided a trade‐off between ease of use and flexibility for configuring advanced processing options.ConclusionAlthough most ASL pipelines can process the common ASL data types, only some (namely, ASLPrep, ASLtbx, BASIL/Quantiphyse, ExploreASL, and MRICloud) are well‐documented, publicly available, support multiple ASL types, have a user‐friendly interface, and can provide a useful starting point for ASL processing. The choice of an optimal pipeline should be driven by specific data to be processed and user experience, and can be guided by the information provided in this ASL inventory.

show abstract

“…Hence, ASL‐measured perfusion can serve as an imaging biomarker for longitudinal assessment of blood flow characteristics in normal human developmental process and in disease. Because perfusion abnormalities are associated with pathophysiological processes such as cancer, 6 neurodegenerative diseases, 7 and kidney diseases, 8 ASL‐measured perfusion changes before and after therapy may provide clinically valuable information about disease progression and treatment response 9 …”

Section: Introductionmentioning

confidence: 99%

“…Hence, ASL-measured perfusion can serve as an imaging biomarker for longitudinal assessment of blood flow characteristics in normal human developmental process and in disease. Because perfusion abnormalities are associated with pathophysiological processes such as cancer, 6 neurodegenerative diseases, 7 and kidney diseases, 8 ASL-measured perfusion changes before and after therapy may provide clinically valuable information about disease progression and treatment response. 9 ASL has also demonstrated good accuracy in the brain compared with [ 15 O]H 2 O-PET, considered gold standard for perfusion imaging 10,11 ; however, its application and clinical validation in other anatomical locations are under development.…”

Section: Introductionmentioning

confidence: 99%

A 3D‐printed phantom for quality‐controlled reproducibility measurements of arterial spin labeled perfusion

Wang,

Greer,

Zhou

et al. 2023

Magnetic Resonance in Med

View full text Add to dashboard Cite

PurposeTo develop a portable MR perfusion phantom for quality‐controlled assessment and reproducibility of arterial spin labeled (ASL) perfusion measurement.MethodsA 3D‐printed perfusion phantom was developed that mimics the branching of arterial vessels, capillaries, and a chamber containing cellulose sponge representing tissue characteristics. A peristaltic pump circulated distilled water through the phantom, and was first evaluated at 300, 400, and 500 mL/min. Longitudinal reproducibility of perfusion was performed using 2D pseudo‐continuous ASL at 20 post‐label delays (PLDs, ranging between 0.2 and 7.8 s at 0.4‐s intervals) over a period of 16 weeks, with three repetitions each week. Multi‐PLD data were fitted into a general kinetic model for perfusion quantification (f) and arterial transit time (ATT). Intraclass correlation coefficient was used to assess intersession reproducibility.ResultsMR perfusion signals acquired in the 3D‐printed perfusion phantom agreed well with the experimental conditions, with progressively increasing signal intensities and decreasing ATT for pump flow rates from 300 to 500 mL/min. The perfusion signal at 400 mL/min and the general kinetic model–derived f and ATT maps were similar across all PLDs for both intrasession and intersession reproducibility. Across all 48 experimental time points, the average f was 75.55 ± 3.83 × 10−3 mL/mL/s, the corresponding ATT was 2.10 ± 0.20 s, and the T1 was 1.84 ± 0.102 s. Intraclass correlation coefficient was 0.92 (95% confidence interval 0.83–0.97) for f, 0.96 (0.91–0.99) for ATT, and 0.94 (0.88–0.98) for T1, demonstrating excellent reproducibility.ConclusionA simple, portable 3D‐printed perfusion phantom with excellent reproducibility of 2D pseudo‐continuous ASL measurements was demonstrated that can serve for quality‐controlled and reliable measurements of ASL perfusion.

show abstract

MRI assessment of cerebral perfusion in clinical trials

Cited by 9 publications

References 75 publications

Albumin-based nanosystem for dual-modality imaging-guided chem-phototherapy against immune-cold triple-negative breast cancer

Albumin-based nanosystem for dual-modality imaging-guided chem-phototherapy against immune-cold triple-negative breast cancer

ISMRM Open Science Initiative for Perfusion Imaging (OSIPI): ASL pipeline inventory

A 3D‐printed phantom for quality‐controlled reproducibility measurements of arterial spin labeled perfusion

Contact Info

Product

Resources

About