MRI and PET imaging discordance in neurosarcoidosis

Huang, Josephine F.; Aksamit, Allen J.; Staff, Nathan P.

doi:10.1212/wnl.0b013e3182684672

Cited by 25 publications

(17 citation statements)

References 1 publication

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“…For example, this MRI/PET mismatch has been reported in spinal neurosarcoidosis. 27 In general, longitudinally extensive and enhancing spinal cord lesions can be seen in paraneoplastic myelopathies, neurosarcoidosis, NMOSD, and, as mentioned above, GFAP-autoantibody-associated neurologic disorders. Recent efforts have been underway to distinguish these entities radiologically.…”

Section: Spinal Cord Imaging Characteristics Of Cns Autoimmune Disordersmentioning

confidence: 97%

Imaging in Autoimmune Neurology

Linnoila

2018

Semin Neurol

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Autoimmune disorders are becoming increasingly recognized within the broader field of neurology. The discovery of multiple, novel, neutrally targeted autoantibodies over the past decade and their translation into commercially available testing, in particular, has aided in the more rapid diagnosis of these disorders. When considering imaging in autoimmune neurologic disorders, it is important, when possible, to visualize the autoimmune process itself, as well as to make sure that the patient does not have an associated malignancy driving the overall process. Positron emission tomographic scans can aid in the detection of small tumors with limited spread, as well as in the visualization of autoimmune processes affecting the brain and/or spinal cord. In autoimmune disorders of the central nervous system, imaging abnormalities can appear within the limbic system, extralimbic areas, and spinal cord. Such imaging abnormalities can serve as objective markers to follow over time to assess patients' responses to treatment. It is important to recognize that overlapping syndromes (for instance, both demyelinating and autoimmune or both infectious and autoimmune) exist and that inflammatory disorders can leave behind sequelae that can be recognized on subsequent imaging. Work is currently underway to develop more specific imaging techniques for autoimmune neurologic disorders.

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Section: Spinal Cord Imaging Characteristics Of Cns Autoimmune Disordersmentioning

confidence: 97%

Imaging in Autoimmune Neurology

Linnoila

2018

Semin Neurol

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“…15 A tissue diagnosis remains the gold standard, 16 often guided by peripheral "hot" nodes identified on fluorodeoxyglucose positron emission tomography (FDG-PET), which has become an effective and accepted method for diagnosis. [17][18][19] Ancillary testing such as optical coherence tomography (OCT) may also prove helpful in assisting with the diagnosis, as retinal abnormalities can sometimes be found on OCT. 20 • Genetic leukodystrophies: The genetic leukodystrophies have undergone a revolution in the last decade due to techniques such as next-generation sequencing. Simple, 21,22 There is also a review of pearls and pitfalls by Dr. Baranano in this issue of Seminars.…”

Section: Diagnostic Pitfallsmentioning

confidence: 99%

Multiple Sclerosis

Calabresi¹,

Schiess²

2016

Semin Neurol

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It is estimated that there are 300,000 people with multiple sclerosis (MS) in the United States and 2.3 million worldwide. Each MS attack can affect function in cognitive, emotional, motoric, sensory, or visual domains. Patients are often struck in the prime of their lives as they attempt to move forward with career, and family. Since the previous 2010 Seminars in Neurology Pearls and Pitfalls issue, the world of MS has drastically changed and advanced. Here the authors address the ever-changing MS world in both treatment options and diagnostics, covering easily missed differential diagnoses, newly available immunomodulatory therapy, and the challenges of safely treating patients.

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“…Whole body [ 18 F]-fluorodeoxyglucose-PET (FDG-PET) can be useful in making a diagnosis of neurosarcoidosis when conventional CNS imaging modalities are unrevealing (Huang and Aksamit, 2012). These types of scans also have been used to follow response to treatment (Braun et al, 2008).…”

Section: Gallium Scan and [ 18 F]-fluorodeoxyglucose-petmentioning

confidence: 99%