MRI and PET/CT of patients with bone metastases from breast carcinoma

Grankvist, J; Fisker, Rune Vincents; Iyer, Victor Vishwanath; Fründ, E T; Simonsen, Carsten; Christensen, T.; Stenbygaard, Lars; Ewertz, Marianne; Em, Larsson

doi:10.1016/j.ejrad.2010.10.024

Cited by 29 publications

(16 citation statements)

References 15 publications

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“…62 Whole-body DW-MRI is evolving as a bone marrow assessment modality for detection and treatment response 63,64 ; however, no response criteria have yet been established.…”

Section: Whole-body Mrimentioning

confidence: 99%

Molecular and Functional Imaging of Bone Metastases in Breast and Prostate Cancers

Azad¹,

Taylor²,

Rubello³

et al. 2016

Clinical Nuclear Medicine

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Our ability to accurately assess the skeleton for metastases in breast and prostate cancers has improved significantly in recent years with hybrid imaging methods. Nevertheless, no consensus has been reached on the best imaging modality for diagnosis and treatment response assessment of skeletal disease. Hybrid SPECT/CT has low false-positive and false-negative rates compared with planar bone scintigraphy (BS) or BS augmented with SPECT in breast and prostate cancers. In breast cancer, 18F-FDG PET is more sensitive and accurate at detecting bone metastases than BS. Currently, little evidence has accrued to support the superiority of 18F-fluoride (18F-NaF) PET in diagnosing osseous metastases or monitoring treatment response in breast cancer when compared with conventional imaging. In prostate cancer, the sensitivities of 18F-NaF PET/CT, 18F-fluorocholine (18F-choline), or 11C-choline PET/CT are equivalent, although 11C-/18F-choline PET/CT scans are more specific. Whole-body MRI, using anatomical sequences complemented by diffusion-weighted MRI, shows early evidence of utility for diagnosis and monitoring therapy response. We review the literature for staging and response assessment in metastatic breast and prostate cancer. While staging accuracy has significantly improved with hybrid imaging, optimal methods for assessing early treatment response have not been determined, and this is an area of active research.

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“…62 Whole-body DW-MRI is evolving as a bone marrow assessment modality for detection and treatment response 63,64 ; however, no response criteria have yet been established.…”

Section: Whole-body Mrimentioning

confidence: 99%

Molecular and Functional Imaging of Bone Metastases in Breast and Prostate Cancers

Azad¹,

Taylor²,

Rubello³

et al. 2016

Clinical Nuclear Medicine

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“…In MRI studies investigating bone metastases in breast cancer patients, T 1 -weighted images were found to have the highest sensitivity to detect metastases in the spine and pelvis. The specificity of the MR analysis was improved by combining T 1 -weighted images with DWIs [91]. Detection of cancer-positive pelvic lymph nodes in patients with cervical and uterine cancers reached a sensitivity of 83% and a specificity of 99% by combining size analysis with apparent diffusion-coefficient values, [92].…”

Section: Imaging Metastases and Their Environmentsmentioning

confidence: 99%

MRI of Metastasis-Permissive Microenvironments

2011

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One of the earliest documented observations of the importance of the microenvironment in metastasis was made by Stephen Paget in 1889. More than a century later, the metastatic cascade remains a major cause of mortality from cancer. Cancer meets the criterion of a successful organization that is able to survive by adapting to changing environments. In fact, the tumor microenvironment and stroma are co-opted and shaped by cancer cells to derive a survival advantage. Cohesive strategies integrating advances in molecular biology and chemistry, with noninvasive multimodality imaging, provide new insights into the role of the tumor microenvironment in promoting metastasis from primary tumors as well as insights into environments that attract and permit cancer cells to establish colonies in distant organs. This article provides an overview of molecular and functional imaging characterization of microenvironments that can promote or permit cancer cells to metastasize and the microenvironmental characteristics of distant metastases.

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“…35 MRI is a useful radiation-free alternative for multiple follow-up examinations because regular follow-up scans to monitor treatment response are necessary. 36 However, both whole-body MR imaging and FDG PET showed a higher sensitivity than standard bone scintigraphy for the detection of bone metastases in children and young adults in the study of Daldrup-Link et al 37 In children, the differentiation between highly cellular hematopoietic and neoplastic marrow may be facilitated by in-phase and out-of-phase pulse sequences of MR imaging, which only reduce the signal intensity of hematopoietic macrophage-containing marrow but not of neoplastic marrow. 38 Therefore, for the evaluation of bone metastases in both children and adults, the combination of FDG PET and MRI may be very useful.…”

Section: Soft Tissue Tumormentioning

confidence: 99%

Musculoskeletal Applications of PET/MR

Lee

Jin

Hong

et al. 2014

Semin Musculoskelet Radiol

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To overcome each limitation of morphological and functional imaging procedures, hybrid imaging systems have been developed and introduced into clinical routine. It has been increasingly discussed whether magnetic resonance imaging (MRI) might be an appropriate alternative for computed tomography (CT). The major advantage of positron emission tomography (PET)/MR consists of combined metabolic and anatomical information in a single imaging session that provides superior soft tissue characterization of MRI over CT. Until now, fusion image has been effectively utilized in oncologic indications. Because biopsy cannot be replaced by images for definite diagnosis, fusion imaging may be more efficient for staging based on nodal spread or metastases rather than the diagnosis of primary tumor, and it can be proficient for treatment response or postoperative assessment. This review describes mainly oncologic and nontumorous conditions among the musculoskeletal applications of PET/MR.

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MRI and PET/CT of patients with bone metastases from breast carcinoma

Cited by 29 publications

References 15 publications

Molecular and Functional Imaging of Bone Metastases in Breast and Prostate Cancers

Molecular and Functional Imaging of Bone Metastases in Breast and Prostate Cancers

MRI of Metastasis-Permissive Microenvironments

Musculoskeletal Applications of PET/MR

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