Mri and Neurological Findings in Patients with Spinal Metastases

Switlyk, Marta D.; Hole, Knut Håkon; Skjeldal, Sigmund; Hald, John; Knutstad, K.; Seierstad, Therese; Zaikova, Olga

doi:10.1258/ar.2012.120442

Cited by 15 publications

(10 citation statements)

References 26 publications

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“…Compression of the cauda equina was defined as an obliteration of the cerebrospinal fluid in the dural sac at the affected level. Nerve root compression was defined as contact between the tumor masses or bone fragments and the spinal nerves in the recess or intervertebral foramen [16] .…”

Section: Methodsmentioning

confidence: 99%

Radiotherapy for spinal metastases from breast cancer with emphasis on local disease control and pain response using repeated MRI

Switlyk

Bruland

Skjeldal

et al. 2014

Journal of Bone Oncology

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AimsTo evaluate metastatic lesions within the radiation field using repeated magnetic resonance imaging (MRI) and to compare the imaging findings with pain response following radiotherapy (RT) in patients with spinal metastases (SM) from breast cancer.Material and methods32 Patients with SM from breast cancer admitted for fractionated RT were included in this study. MRI examinations of the spine were scored for the extent of bone metastases, epidural disease and the presence and severity of vertebral fractures. Clinical response was defined according to the updated international consensus on palliative RT endpoints.ResultsAt 2 and 6 months after RT, 38% and 44% of the patients were classified as responders. None of the patients developed motor deficits. Importantly, a decrease in the intraspinal tumor volume after RT was reported in all patients. Only 6% of the patients showed bone metastases progression within the RT field, whereas 60% of the patients showed disease progression outside the RT portals. 5 Patients developed new fractures after RT, and fracture progression was observed in 21 of the 38 lesions (55%). The pain response to RT did not correlate with the presence of vertebral body fracture before RT, fracture progression or other recorded MRI features of metastatic lesions.ConclusionRT provided excellent local tumor control in patients with SM. Most patients benefit from RT even in cases of progressive vertebral fracture. Pain response was not associated with imaging findings and MRI cannot be used to select patients at risk of not responding to RT.

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Section: Methodsmentioning

confidence: 99%

Radiotherapy for spinal metastases from breast cancer with emphasis on local disease control and pain response using repeated MRI

Switlyk

Bruland

Skjeldal

et al. 2014

Journal of Bone Oncology

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“…Metabolism of the intervertebral disc is realized by diffusion of the endplate. The cartilage endplate and brocartilage ring act as a barrier to tumor expansion [17] .…”

Section: Brucella Spondylitismentioning

confidence: 99%

Role of magnetic resonance imaging in the differential diagnosis of spinal signal changes caused by infection and tumor in the early stages

Chen

et al. 2021

Preprint

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Background: Spinal infection and tumor have abnormal magnetic resonance imaging (MRI) manifestations in the early stages; however, they are not easy to identify before symptoms appear. These conditions have their own characteristics and need to be correctly diagnosed.Methods: MRI images of six cases of pyogenic spondylitis, eight cases of tuberculous spondylitis, eight cases of Brucella spondylitis, and twelve cases of spinal tumor were reviewed. MRI images of the involved vertebral body, vertebral facet joint, spinous process, paravertebral soft tissue, and posterior dural sac of the vertebral body were analyzed using T2-weighted imaging, T1-weighted imaging, lipgraphy and enhanced MRI, respectively. Results: MRI data of spinal infection, spinal tuberculosis, spinal tumor, and spinal Brucella infection differed in their characteristics.Conclusions: MRI could provide early diagnostic evidence for spinal lesions.

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“…Integraler Bestandteil des Initialstagings ist ebenso eine 3-Phasen-Knochenszintigrafi e für die Erkennung von Knochenmetastasen. Da die Behandlung (neo-)adjuvant ebenfalls meist zusätzlich eine Chemotherapie umfasst und die Rate von Rezidiven nicht unerheblich ist, wird ebenso eine [ 18…”

Section: Primäre Knochentumorenunclassified

“…Die Vorteile der MRT gegenüber den übrigen Verfahren gehen allerdings über die Detektion und Diff erenzierung von Knochenmetastasen hinaus. Liegen Knochenmetastasen vor, so ist die häufi gste Lokalisation das blutbildende Knochenmark des Stammskeletts mit Schwerpunkt in der Wirbelsäule [ 18 ] . Bei Wirbelkörperfrakturen, der häufi gsten Komplikation von Wirbelkörpermetastasen, ist eine MRT der Wirbelsäule ohnehin der nächste diagnostische Schritt.…”

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MRT des Skelettsystems in der Onkologie

2014

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Zusammenfassung Die Magnetresonanztomografie (MRT) stellt in der Diagnostik von degenerativen und traumatischen Ver?nderung des Bewegungsapparats eine Referenzmethode ohne Strahlenexposi?tion dar. Auch in der Diagnostik maligner Knochenl?sionen bietet sie, nicht zuletzt durch die M?glichkeit zur Ganzk?rper-MRT, eine akkurate Erfassung der Pathologien im gesamten Skelettsystem. Die MRT ist allerdings nicht ohne Limitationen und bei jedem Patienten uneingeschr?nkt anwendbar. Abh?ngig von Indikation und Skelett?abschnitt stellt Sie jedoch eine wertvolle Alternative oder Erg?nzung der ?brigen nuklearmedi?zinischen und radiologischen Diagnostik dar.

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Mri and Neurological Findings in Patients with Spinal Metastases

Abstract: In patients with neurological dysfunction, the presence and severity of impairment was associated with the epidural tumor burden. A significant number of patients had radiological spinal cord compression and normal motor function (occult MSCC).

Cited by 15 publications

References 26 publications

Radiotherapy for spinal metastases from breast cancer with emphasis on local disease control and pain response using repeated MRI

Radiotherapy for spinal metastases from breast cancer with emphasis on local disease control and pain response using repeated MRI

Role of magnetic resonance imaging in the differential diagnosis of spinal signal changes caused by infection and tumor in the early stages

MRT des Skelettsystems in der Onkologie

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