MRI and MR tractography in bilateral hypertrophic olivary degeneration

Sen, Debraj; Gulati, Yoginder S.; Malik, Virender; Mohimen, Aneesh; Sibi, Eranki; Reddy, Deepak Chandra

doi:10.4103/0971-3026.143902

Cited by 10 publications

(10 citation statements)

References 11 publications

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“…It is noteworthy that the original tumor location is not visualized, but only the localization of the destructive lesion through therapeutic (e.g., neurosurgical) intervention. The model schematizes that a single strategic lesion located at the crossroad between the two superior cerebellar peduncles can induce bilateral HOD by affecting both GMT [17,18].…”

Section: Model Of Hod Predictionmentioning

confidence: 99%

Delayed Occurrence of Hypertrophic Olivary Degeneration after Therapy of Posterior Fossa Tumors: A Single Institution Retrospective Analysis

Schaller‐Paule

Foerch

Kluge

et al. 2019

JCM

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(1) Background: A lesion within the dentato-rubro-olivary pathway (DROP) in the posterior fossa can cause secondary neurodegeneration of the inferior olivary nucleus: so-called hypertrophic olivary degeneration (HOD). The clinical syndrome of HOD occurs slowly over months and may be overlooked in progressive neuro-oncological diseases. Posterior fossa tumors are often located near these strategic structures. The goal of this study was to analyze the systematics of HOD occurrence in neuro-oncological patients. (2) Methods: The neuroradiological database of the university healthcare center was scanned for HOD-related terms from 2010 to 2019. After excluding patients with other causes of HOD, 12 datasets from neuro-oncological patients were analyzed under predetermined criteria. (3) Results: Patients received multimodal tumor treatments including neurosurgery, radiotherapy, and chemotherapy. HOD occurred both unilaterally (left n = 4; right n = 5) and bilaterally (n = 3). Though the mass effect of posterior fossa tumors had already affected strategic structures of the DROP, none of the patients showed signs of HOD on MRI until therapeutic measures including neurosurgery affecting the DROP were applied. HOD was visible on MRI within a median of 6 months after the neurosurgical intervention. In 67%, the presumed underlying surgical lesion in the DROP lay in the contralateral dentate nucleus. (4) Conclusion: In a selected cohort of neuro-oncological patients, therapeutic lesions within the DROP were associated with HOD occurrence.

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Section: Model Of Hod Predictionmentioning

confidence: 99%

Delayed Occurrence of Hypertrophic Olivary Degeneration after Therapy of Posterior Fossa Tumors: A Single Institution Retrospective Analysis

Schaller‐Paule

Foerch

Kluge

et al. 2019

JCM

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“…It is usually associated with hypertrophic degeneration of the ION, which can be seen on MR images as a high signal on T2- or proton density-weighted images with ION enlargement [ 18 ]. Hypertrophic olivary degeneration is a trans-synaptic neuronal degeneration in which degeneration is accompanied by hypertrophy [ 41 ]. Increased signals from the ION are present within one month of disease onset, and the high signal continues for several years [ 18 ].…”

Section: Clinical Features (Phenomenology)mentioning

confidence: 99%

Movement Disorders Following Cerebrovascular Lesions in Cerebellar Circuits

Choi¹

2016

JMD

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Cerebellar circuitry is important to controlling and modifying motor activity. It conducts the coordination and correction of errors in muscle contractions during active movements. Therefore, cerebrovascular lesions of the cerebellum or its pathways can cause diverse movement disorders, such as action tremor, Holmes’ tremor, palatal tremor, asterixis, and dystonia. The pathophysiology of abnormal movements after stroke remains poorly understood. However, due to the current advances in functional neuroimaging, it has recently been described as changes in functional brain networks. This review describes the clinical features and pathophysiological mechanisms in different types of movement disorders following cerebrovascular lesions in the cerebellar circuits.

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“…There are three patterns of HOD, depending on the location of the primary lesion: 1) ipsilateral to the primary lesion, 2) contralateral to the primary lesion, and 3) bilateral (Figure 5) [5,6].…”

Section: Discussionmentioning

confidence: 99%

Hypertrophic olivary degeneration in a 16-year-old girl after subtotal surgery of a brainstem pilocytic astrocytoma – a case report

Sobieraj¹,

Duczkowski²,

Terczyńska³

et al. 2019

Pol J Radiol

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Purpose Hypertrophic olivary degeneration (HOD) is a unique neurological condition caused by interruption of the dentato-rubro-olivary pathway, also known as the triangle of Guillain and Mollaret. Magnetic resonance (MR) imaging is the best modality to diagnose both the degeneration of the inferior olivary nucleus and the underlying cause. Case report We describe a case of a unilateral HOD in a 16-year-old girl several months after a subtotal excision of a brainstem pilocytic astrocytoma. Taking into account the patient’s history, tumour recurrence must have been considered, but the typical location and MR morphology, as well as the time of occurrence after brainstem surgery, contributed to the diagnosis of HOD. The causative factor was the interruption of the central tegmental tract, which forms one arm of the Guillain and Mollaret triangle. Additionally, this is an interesting case of a child, who stayed in a coma for several months following brainstem surgery, but finally was discharged home with only minor neurological defects and returned to normal life. Conclusions Hypertrophic olivary degeneration is an infrequent neurological condition, especially in the paediatric population. Nevertheless, it should be considered when interpreting late postoperative scans of children with a history of a brain tumour.

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MRI and MR tractography in bilateral hypertrophic olivary degeneration

Cited by 10 publications

References 11 publications

Delayed Occurrence of Hypertrophic Olivary Degeneration after Therapy of Posterior Fossa Tumors: A Single Institution Retrospective Analysis

Delayed Occurrence of Hypertrophic Olivary Degeneration after Therapy of Posterior Fossa Tumors: A Single Institution Retrospective Analysis

Movement Disorders Following Cerebrovascular Lesions in Cerebellar Circuits

Hypertrophic olivary degeneration in a 16-year-old girl after subtotal surgery of a brainstem pilocytic astrocytoma – a case report

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