“…Although it has been thoroughly described that transcription is generally repressed after the appearance of DSBs ( Shanbhag et al, 2010 ; Pankotai et al, 2012 ; Kim et al, 2015 ; Manfrini et al, 2015 ), some labs have reported de novo transcription around the DSB ( Francia et al, 2012 ; Ohle et al, 2016 ; Michelini et al, 2017 ; D’Alessandro et al, 2018 ; Burger et al, 2019 ; Pessina et al, 2019 ; Vítor et al, 2019 ; Sharma et al, 2021 ). Thus, after DNA damage, RNA polymerase II is supposed to be recruited to the damaged chromatin and to start transcription around the break.…”