MRD positivity was the poor prognostic factor for adverse-risk AML patients with allogeneic hematopoietic stem cell transplantation: a multicenter TROPHY study

Cao, Yang; Huo, Wenxuan; Huang, Jiayu; Yang, Yang; Wang, Yu; Chang, Yingjun; Wang, Luxiang; Zhang, Zilu; Jiang, Chuanhe; Hu, Xiaoxia; Mo, Xiaodong

doi:10.1038/s41408-024-00976-1

Cited by 2 publications

(1 citation statement)

References 23 publications

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“…According to the findings of another study, differential cytometry MRD analysis is crucial at three specified intervals prior to allogeneic hematopoietic stem cell transplantation. Consequently, if moderate response is not attained with primary drugs following initial treatment of mild disease, the physician may contemplate secondary drug options based on this study [38]. Lastly, another research, however, concerns several approaches with the aid of which to detect minimal residual disease of AML is tracked.…”

Section: Discussionmentioning

confidence: 99%

Application of cytogenetic studies to assess relapse in patients after allogeneic bone marrow transplantation

2024

FEM

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Ergospirometry is a modern approach to the diagnosis of physical health that involves the use of exercise testing to measure cardiopulmonary function. Aims: To compare the distribution of health characteristics and their relationship between participants, to evaluate the accuracy of hypertension, hyperlipidemia and diabetes in both groups, to measure respiratory rate and heart rate between ergospirometric testing and traditional testing for physical health assessment. Study design: A comparative cross-sectional design to assess ergospirometric testing and traditional testing for physical health assessment. Methodology: The study employed a comparative cross-sectional design, utilizing convenience sampling to recruit participants for ergospirometric testing on a treadmill and the traditional 6-Minute Walk Test. Sample size determination yielded 100 participants (50 per group). Data on sociodemographic, comorbidities, and physiological parameters were collected and analyzed using descriptive statistics, chi-square tests, and independent sample t-tests. Results: The study compared Ergometric testing on a treadmill with the Traditional 6-Minute Walk Test across various parameters. Participants undergoing Ergometric testing were younger with more females and smokers, while the Walk Test group had higher BMI and exercise rates. Ergometric testing revealed higher rates of hypertension (P = 0.034) and hyperlipidemia (P = 0.021) but lower diabetes prevalence (P = 0.016). Additionally, Ergometric testing showed a better detection of respiratory parameters, exercise stress detection (P = 0.009), and cardiovascular parameters as compared to Traditional testing. Furthermore, it has a higher sensitivity 85% and specificity 80% compared to the traditional testing having sensitivity 75%, and specificity 70%. Scientific Novelty: Spirometry testing has made an impact on physical examination today; using advanced technology to achieve the best, sensitivity and specificity marks changes in the actual examination. Conclusion: Ergometric testing (treadmill) shows a significant advantage over traditional testing (6-Minute Walk Test) in diagnosing physical health conditions with a high sensitivity, specificity, and comprehensive parameter assessment.

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Section: Discussionmentioning

confidence: 99%

Application of cytogenetic studies to assess relapse in patients after allogeneic bone marrow transplantation

2024

FEM

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Basiliximab Treatment for Patients With Steroid-Refractory Acute Graft-Versus-Host Disease Following Matched Sibling Donor Hematopoietic Stem Cell Transplantation

Jiang,

Zhang,

et al. 2024

Cell Transplant

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Basiliximab is an important treatment for steroid-refractory acute graft-versus-host disease (SR-aGVHD). We performed this retrospective study to evaluate the efficacy and safety of basiliximab treatment in SR-aGVHD patients following matched sibling donor hematopoietic stem cell transplantation (MSD-HSCT) ( n = 63). Overall response rate (ORR) was 63.5% and 54% at any time and at day 28 after basiliximab treatment. Grade III–IV aGVHD before basiliximab treatment predicted a poor ORR after basiliximab treatment. The rates of virus, bacteria, and fungi infections were 54%, 23.8%, and 3.1%, respectively. With a median follow-up of 730 (range, 67–3,042) days, the 1-year probability of overall survival and disease-free survival after basiliximab treatment were 58.6% (95% confidence interval [CI] = 47.6%–72.2%) and 55.4% (95% CI = 44.3%–69.2%), respectively. The 3-year cumulative incidence of relapse and non-relapse mortality after basiliximab treatment were 18.9% (95% CI = 8.3%–29.5%) and 33.8% (95% CI = 21.8%–45.7%), respectively. Comorbidities burden before allo-HSCT, severity of aGVHD and liver aGVHD before basiliximab treatment showed negative influences on survival. Thus, basiliximab was safe and effective treatment for SR-aGVHD following MSD-HSCT.

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MRD positivity was the poor prognostic factor for adverse-risk AML patients with allogeneic hematopoietic stem cell transplantation: a multicenter TROPHY study

Cited by 2 publications

References 23 publications

Application of cytogenetic studies to assess relapse in patients after allogeneic bone marrow transplantation

Application of cytogenetic studies to assess relapse in patients after allogeneic bone marrow transplantation

Basiliximab Treatment for Patients With Steroid-Refractory Acute Graft-Versus-Host Disease Following Matched Sibling Donor Hematopoietic Stem Cell Transplantation

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