MR Spectroscopy Shows Reduced Frontal Lobe Concentrations of N‐Acetyl Aspartate in Patients with Juvenile Myoclonic Epilepsy

Abstract

The observed reduction in NAA levels suggests a prefrontal neuronal lesion in patients with JME.

“Here, There, Everywhere”, or is it Truly Partial Epilepsy?

“…In a quantitative analysis in patients with juvenile myoclonic epilepsy (JME) he found an increase in cortical gray matter in the mesial frontal lobes 10 . Savic et al (2000) drew similar conclusions from MRI spectroscopy study in this population of patients 11 . Animal studies have also suggested temporal lobe abnormality may play a role in the pathophysiology of IGE 12 .…”

Automatic quantitation of localized in vivo1H spectra with LCModel

“…19 Smaller, precisely localized volumes permit studies of absolute concentrations and relaxation of metabolites in difficult regions such as the hippocampus. 20 LCModel has been applied at 1.5 and 2.0 T to studies of epilepsy, 15,17,21,22 multiple sclerosis, [23][24][25] tumors, [26][27][28] Alzheimer's disease 29 and other pathologies, [30][31][32][33][34][35] including the identification and quantitation of unusual metabolites. 36,37 Many other applications of LCModel to childhood disorders can be found in a review article.…”

Restoration of motion‐related signal loss and line‐shape deterioration of proton MR spectra using the residual water as intrinsic reference

“…To assess the improvement of spectral quality, the spectra were evaluated with and without correction for zero-phase and frequency shifts prior to averaging, and with additional eddy current correction from a single reference acquisition of the unsuppressed water signal (12). Locations in white matter of the centrum semiovale superior to the basal ganglia (WM, excluding the ventricles), prefrontal and occipital gray matter (GM), a cerebellar hemisphere and the thalamus were examined for putative regional differences using the control groups of clinical studies and additional subjects (unpublished data) (13). Informed written consent was obtained prior to each examination.…”