MR spectroscopy measurement of the diffusion of dimethyl sulfoxide in articular cartilage and comparison to theoretical predictions

Abazari, Alireza; Elliott, Janet A.W.; McGann, Locksley E.; Thompson, Richard B.

doi:10.1016/j.joca.2012.04.023

Cited by 25 publications

(12 citation statements)

References 22 publications

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“…Solute diffusivity in cartilage is smaller than in an aqueous solution [10]. Diffusivity depends on tissue strain and decreases as the tissue is compressed [120][121][122][123]. Solute diffusivity also depends on the size of the solute.…”

Section: Review Of Cartilage Structure and Mechanicsmentioning

confidence: 99%

“…Permeability, diffusive drag, and solute diffusivity constants or rules govern fluid flow, ion transport, and solute transport [152]. Strain-dependent permeability and strain-dependent solute diffusivity are important considerations in cartilage undergoing large deformations [101,118,[120][121][122][123][153][154][155][156]. Specific combinations of multiphasic constituents have been used to successfully describe specific sets of cartilage behavior.…”

Section: Review Of Cartilage Structure and Mechanicsmentioning

confidence: 99%

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Subject-Specific Analysis of Joint Contact Mechanics: Application to the Study of Osteoarthritis and Surgical Planning

Henak

Anderson

Weiss

2013

Journal of Biomechanical Engineering

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Advances in computational mechanics, constitutive modeling, and techniques for subject-specific modeling have opened the door to patient-specific simulation of the relationships between joint mechanics and osteoarthritis (OA), as well as patient-specific preoperative planning. This article reviews the application of computational biomechanics to the simulation of joint contact mechanics as relevant to the study of OA. This review begins with background regarding OA and the mechanical causes of OA in the context of simulations of joint mechanics. The broad range of technical considerations in creating validated subject-specific whole joint models is discussed. The types of computational models available for the study of joint mechanics are reviewed. The types of constitutive models that are available for articular cartilage are reviewed, with special attention to choosing an appropriate constitutive model for the application at hand. Issues related to model generation are discussed, including acquisition of model geometry from volumetric image data and specific considerations for acquisition of computed tomography and magnetic resonance imaging data. Approaches to model validation are reviewed. The areas of parametric analysis, factorial design, and probabilistic analysis are reviewed in the context of simulations of joint contact mechanics. Following the review of technical considerations, the article details insights that have been obtained from computational models of joint mechanics for normal joints; patient populations; the study of specific aspects of joint mechanics relevant to OA, such as congruency and instability; and preoperative planning. Finally, future directions for research and application are summarized.

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Section: Review Of Cartilage Structure and Mechanicsmentioning

confidence: 99%

Section: Review Of Cartilage Structure and Mechanicsmentioning

confidence: 99%

Subject-Specific Analysis of Joint Contact Mechanics: Application to the Study of Osteoarthritis and Surgical Planning

Henak

Anderson

Weiss

2013

Journal of Biomechanical Engineering

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“…Such models can make calculations of pertinent properties—cryoprotectant concentration, cytotoxicity, solution freezing point, vitrifiability, and/or temperature—as a function of location in the cartilage and time of exposure. For example, cryoprotectant concentration has been calculated using biomechanical models 17 – 19 and Fick’s law 20 – 23 ; a mathematical toxicity cost function was introduced by Benson et al 24 to quantify the cumulative toxicity experienced by cells over the course of cryoprotectant loading; and vitrifiability 23 , 25 and freezing point 23 , 26 , 27 have been accurately modeled. These mathematical models usually require parameters extracted from experimental data that can depend on tissue type, cryoprotectant type, and temperature.…”

Section: Introductionmentioning

confidence: 99%

Vitrification of particulated articular cartilage via calculated protocols

Shardt

Laouar

et al. 2021

npj Regen Med

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Preserving viable articular cartilage is a promising approach to address the shortage of graft tissue and enable the clinical repair of articular cartilage defects in articulating joints, such as the knee, ankle, and hip. In this study, we developed two 2-step, dual-temperature, multicryoprotectant loading protocols to cryopreserve particulated articular cartilage (cubes ~1 mm3 in size) using a mathematical approach, and we experimentally measured chondrocyte viability, metabolic activity, cell migration, and matrix productivity after implementing the designed loading protocols, vitrification, and warming. We demonstrated that porcine and human articular cartilage cubes can be successfully vitrified and rewarmed, maintaining high cell viability and excellent cellular function. The vitrified particulated articular cartilage was stored for a period of 6 months with no significant deterioration in chondrocyte viability and functionality. Our approach enables high-quality long-term storage of viable articular cartilage that can alleviate the shortage of grafts for use in clinically repairing articular cartilage defects.

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“…However, ice formation outside of the cells is not innocuous in a tissue, as has been shown by several investigators [27,[33][34][35][36][37]. Even with well-intentioned attempts to prevent intracellular ice formation, gradients of cryoprotectant concentrations and osmotic imbalances across a tissue can result in varying levels of stress and post-thaw viability across a tissue [38,39] (see discussion in [40]), resulting in damage associated with cryoprotectant toxicity and excessive osmotic stress.…”

Section: Heat and Mass Transfer During Organ Cryopreservationmentioning

confidence: 97%

Organ Preservation: Cryobiology and Beyond

Woods

Mullen

2016

Curr Stem Cell Rep

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Advances in surgical techniques, immunology, and organ donor networking have allowed organ transplantation to evolve over the last several decades into a procedure that has saved hundreds of thousands of lives. While these dramatic advances have made organ transplantation more effective, they have also highlighted the growing shortage of donor organs. Unfortunately, many organs that could be of potential use for transplantation end up discarded due to short preservation times, often only 4-12 h for vital organs. Organ preservation systems have been investigated with renewed vigor in attempts to solve this problem, and new tools are becoming available that make solutions much more possible than ever before. The cryobiology of organs must be understood for long-term banking solutions to be feasible, combined with greater understanding of the physio-chemical processes that take place during ischemia and reperfusion. New approaches based on natural models, stem cells, and various novel proteins and trophic factors all show great promise in accomplishing the goal of more donor organs matched with more patients in need.

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MR spectroscopy measurement of the diffusion of dimethyl sulfoxide in articular cartilage and comparison to theoretical predictions

Cited by 25 publications

References 22 publications

Subject-Specific Analysis of Joint Contact Mechanics: Application to the Study of Osteoarthritis and Surgical Planning

Subject-Specific Analysis of Joint Contact Mechanics: Application to the Study of Osteoarthritis and Surgical Planning

Vitrification of particulated articular cartilage via calculated protocols

Organ Preservation: Cryobiology and Beyond

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