MR Spectroscopy evaluation of white matter signal abnormalities of different non-neoplastic brain lesions

Kaddah, Randa O.; Khalil, Mohsen Elsayed

doi:10.1016/j.ejrnm.2015.10.010

Cited by 9 publications

(8 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lactate is an end-product of oxidative metabolism and is therefore a potentially interesting biomarker for a metabolism-associated illness such as ME/CFS. Lactate levels in healthy brain tissue are so low as to be almost undetectable by conventional MRS at 1.5T or 3T magnet strength, but when measured in ventricular cerebrospinal fluid, elevated lactate is associated with neuroinflammation (33, 87–92).…”

Section: Magnetic Resonance Spectroscopy (Mrs) In Neuroinflammationmentioning

confidence: 99%

Neuroinflammation and Cytokines in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Critical Review of Research Methods

2019

View full text Add to dashboard Cite

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is the label given to a syndrome that can include long-term flu-like symptoms, profound fatigue, trouble concentrating, and autonomic problems, all of which worsen after exertion. It is unclear how many individuals with this diagnosis are suffering from the same condition or have the same underlying pathophysiology, and the discovery of biomarkers would be clarifying. The name “myalgic encephalomyelitis” essentially means “muscle pain related to central nervous system inflammation” and many efforts to find diagnostic biomarkers have focused on one or more aspects of neuroinflammation, from periphery to brain. As the field uncovers the relationship between the symptoms of this condition and neuroinflammation, attention must be paid to the biological mechanisms of neuroinflammation and issues with its potential measurement. The current review focuses on three methods used to study putative neuroinflammation in ME/CFS: (1) positron emission tomography (PET) neuroimaging using translocator protein (TSPO) binding radioligand (2) magnetic resonance spectroscopy (MRS) neuroimaging and (3) assays of cytokines circulating in blood and cerebrospinal fluid. PET scanning using TSPO-binding radioligand is a promising option for studies of neuroinflammation. However, methodological difficulties that exist both in this particular technique and across the ME/CFS neuroimaging literature must be addressed for any results to be interpretable. We argue that the vast majority of ME/CFS neuroimaging has failed to use optimal techniques for studying brainstem, despite its probable centrality to any neuroinflammatory causes or autonomic effects. MRS is discussed as a less informative but more widely available, less invasive, and less expensive option for imaging neuroinflammation, and existing studies using MRS neuroimaging are reviewed. Studies seeking to find a peripheral circulating cytokine “profile” for ME/CFS are reviewed, with attention paid to the biological and methodological reasons for lack of replication among these studies. We argue that both the biological mechanisms of cytokines and the innumerable sources of potential variance in their measurement make it unlikely that a consistent and replicable diagnostic cytokine profile will ever be discovered.

show abstract

Section: Magnetic Resonance Spectroscopy (Mrs) In Neuroinflammationmentioning

confidence: 99%

Neuroinflammation and Cytokines in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Critical Review of Research Methods

2019

View full text Add to dashboard Cite

show abstract

“…This in line with previous work stated that, lactate is only found in pathologic states and acute stroke due to anaerobic glycolysis performed by the brain in ischemia or due to macrophage activation after membrane break down, as macrophages uses lactate for their energy supply [12] . Karatag et [13] evaluated the peak of LL in all cases and used it if present with Cho/Cr > 2.2 to differentiate high-from low grade neoplastic lesions with a sensitivity of 100% [82.2-100] and a specificity of 100% Kaddah et al [14] demonstrated that, the characteristic metabolite change of encephalitis was significant reduction of NAA and NAA/Cr ratio. This reduction was significant in the chronic phase of the disease, and gradual recovery was observed within 1 year.…”

Section: Discussionmentioning

confidence: 99%

Magnetic Resonance Spectroscopy Role in Assessment of Pediatric Supratentorial Brain Lesions

Elgamal

El-Wahab

Shakweer

2022

International Journal of Medical Arts

View full text Add to dashboard Cite

Article informationBackground: Magnetic resonance spectroscopy [MRS] is of value for pediatric neurologist, as it confers relevant information from the clinical point of view. It is worth for brain tumors, infections and disorders of the white matter. MRS metabolites add additional value to the therapeutic solutions when MRS combined with other high-resolution imaging modalities. Objective:The current work aimed to assess the role of magnetic resonance spectroscopy in pediatric supratentorial brain lesions. Patients and methods: This study recruited a convenient sample of thirty patients [21 females and 9 males]. Their age ranged between one and sixteen years. All were submitted to single-voxel H-MR spectroscopy with the same MR unit using point resolved spectroscopy [PRESS] sequence, using short TE [35] and long TE [144] spectra. Then spectrum analysis was performed to obtain the important ratios: choline/Nacetylaspartate, choline/creatine and mI/Cr to reach the diagnosis of the supratentorial lesion. Result: The choline/N-acetylaspartate [Cho/NAA], choline/creatine [Cho/Cr] and mI/Cr ratios were statistically difference between neoplastic and non-neoplastic lesions at cutoffs 2, 1.6, & 1.15 respectively. The peak of lipid lactate was only present and significant for differentiating high-from low-grade tumors. Conclusion: MRS is valuable in differential diagnosis of brain lesions, as it differentiates neoplastic from non-neoplastic tumors. It also plays a complementary role with magnetic resonance imaging [MRI] in the follow up of therapeutic response.

show abstract

“…MRI showed an isolated ovoid lesion at the SCC. The MR metabolites spectrum did not support the ischemic hypothesis, as in ischemia the NAA peak is usually reduced with elevated peaks of Lac/Lip, nor the neoplastic or acute demyelinizing hypotheses, as in tumors and multiple sclerosis acute plaques the Cho peak is usually elevated, with Cho/NAA ratio >1 [23][24][25].…”

Section: Discussionmentioning

confidence: 99%

“…90 Diagnosis is confirmed by the disappearance of the lesion within a few weeks [8]. Magnetic Resonance Spectroscopy (MRS) detects brain metabolites alterations, providing further information about the nature and of the lesions [23][24][25]. There are few previous studies of MRS of SCC transient lesions which 95 demonstrated a normal spectrum of the main brain metabolites such as N-acetylaspartate (NAA), choline (Cho), © and creatine (Cr), but presence of peaks of myoinositol (MI) and lactate (Lac), not detectable in normal brain parenchyma, suggesting hyperosmolar state and increased anaerobic glycolysis in the 100 splenium without irreversible neuroaxonal damage [23][24][25].…”

Section: Q4mentioning

confidence: 99%

Treatment-related transient splenial lesion of the Corpus Callosum in patients with neuropsychiatric disorders: a literature overview with a case report

Cirnigliaro

Bernardo

Caricasole

et al. 2020

Expert Opinion on Drug Safety

View full text Add to dashboard Cite

Q1Introduction: Transient-localized © lesions of the splenium of the corpus callosum (SCC) have been described in various clinical conditions, some of them being attributed to the withdrawal of psychotropic drugs. The pathophysiology of the lesion likely reflects cytotoxic edema and reversible demyelination.Areas covered: The present article aimed at reviewing cases of transient SCC lesion exclusively related to changes in pharmacological treatment. It also reports the original case of a psychotic patient receiving a complex psychopharmacological therapy who developed a transient SCC lesion investigated by magnetic resonance imaging (MRI), magnetic resonance spectroscopy (MRS), © and pharmacogenetic profiling. Expert opinion: To date, only one review on the subject has been published, analyzing 22 cases of transient SCC lesion arising in epileptic patients on antiepileptic therapy. It hypothesized that the nature of the lesion is a cytotoxic edema and the cases described in the subsequent 14 years seem to support this hypothesis. The authors reported the case of an Italian-Egyptian patient who developed a transient SCC lesion after the rapid withdrawal of Carbamazepine and Lurasidone. The lesion completely disappeared from the MRI performed after 1 month © . Patient's ethnic group and its specific pharmacogenetic profile were considered as possible causes of altered drug metabolism and, likely, of the SCC lesion. Q2 ARTICLE HISTORY

show abstract

MR Spectroscopy evaluation of white matter signal abnormalities of different non-neoplastic brain lesions

Cited by 9 publications

References 25 publications

Neuroinflammation and Cytokines in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Critical Review of Research Methods

Neuroinflammation and Cytokines in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Critical Review of Research Methods

Magnetic Resonance Spectroscopy Role in Assessment of Pediatric Supratentorial Brain Lesions

Treatment-related transient splenial lesion of the Corpus Callosum in patients with neuropsychiatric disorders: a literature overview with a case report

Contact Info

Product

Resources

About