MR-sequences for prostate cancer diagnostics: validation based on the PI-RADS scoring system and targeted MR-guided in-bore biopsy

Abstract

• T2WI + DWI + DCE achieved the highest accuracy in patients with higher grade PCa • T2WI + DWI + DCE was more accurate for peripheral- than for transitional-zone PCa • DCE increased PCa detection accuracy in the peripheral zone • DWI was the leading sequence in the transitional zone.

Multiparametric MRI of the prostate at 3 T: limited value of 3D 1H-MR spectroscopy as a fourth parameter

“…A second group using four-parameter MP-MRI of the prostate did not calculate a sum score, but described a limited clinical utility for 1 H-MRSI. Using three parameters, investigators have reported a sensitivity of 80-95 %, a specificity of 62-92 %, and an area under the ROC curve of 69-97 % [9,10,12,[17][18][19]. These findings are in good agreement with our results, showing similar sensitivity and specificity.…”

“…We chose this approach, as the latest PI-RADS version (v2) does not include 1 H-MRSI in its specific reporting recommendations. On the other hand, the used sum score has shown to be valid, robust, and reliable approach by several researchers [8][9][10][11][12][13].…”

“…In addition, a simple sum of the individual MP-MRI parameters was calculated for each index lesion [6][7][8][9][10][11][12][13]. The index lesion was defined as the most suspect intraprostatic lesion with the highest sum score.…”

The use of targeted MR-guided prostate biopsy reduces the risk of Gleason upgrading on radical prostatectomy

“…MpMRI included T2-and T1-weighted images, diffusion-weighted imaging (DWI), and perfusion imaging (DCE-MRI). The imaging protocol was adapted to the ESUR (European Society of Urogenital Radiology) and has been previously published (Schimmöller et al 2014). DCE-MRI images were post-processed using the DynaCAD software (Invivo, Orlando, FL, USA).…”

Comparison of field-of-view (FOV) optimized and constrained undistorted single shot (FOCUS) with conventional DWI for the evaluation of prostate cancer

“…Diffusion-weighted imaging (DWI) is one of the essential techniques in mp-MRI [3,4]. Further, DWI enables measurement of the apparent diffusion coefficient (ADC), which can be used to predict Gleason score [5,6].…”